DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimC4 and Megf10

DIOPT Version :9

Sequence 1:	NP_609698.2	Gene:	NimC4 / 34824	FlyBaseID:	FBgn0260011	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001094127.1	Gene:	Megf10 / 291445	RGDID:	735084	Length:	1145	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	82/341 - (24%)
Similarity:	115/341 - (33%)	Gaps:	84/341 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NAERDNYCERNE----TIRATVPVTKQRIIVKQPSKWKIWKKTEKITEIYDS---EEEQVTHRLV 74
            |.|..|.|...|    |::.:.|....:|.....:....|.|..:....|.:   ..|:..:|..
  Rat    27 NLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRK 91

  Fly    75 RECCPGYLQVESGLCEPICSRGCPAHASCAAPDRCECISGY--VSARNHQDGSHY---------- 127
            .:||||:.: ...:|.|.|:..| .|..|.||:.|:|..|:  .:..:..||.|:
  Rat    92 SQCCPGFYE-SRDVCVPHCADKC-VHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQC 154

  Fly   128 -----CEPI--------------CETPCPAG---------AQCVTPNT-------CACRDGYTQL 157
                 |.||              ||..|..|         .||....|       |.|..|||..
  Rat   155 KNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGA 219

  Fly   158 QPTDDGVSGGCAPVCRVGDGCAN-GKCIDV-DRCACNSGYRWDKAEERCIE-LSAESISEELETT 219
            ...|....|...|.|.....|.| |.|..| ..|:|.||:......:.|.| ...::.|:|.:..
  Rat   220 FCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCH 284

  Fly   220 EDNTDSPSTSSTAVFTATHCPDDFVLFRGE-CREKQFDSNDVGCLKSGCGPHQTCLD-------S 276
            .......:|..      .||...:.   || |:    |...||.....|.....|::       |
  Rat   285 NGGACDAATGQ------CHCSPGYT---GERCQ----DECPVGTYGVRCAETCRCVNGGKCYHVS 336

  Fly   277 GVCQCSDGYVPEESGE 292
            |.|.|..|:    |||
  Rat   337 GTCLCEAGF----SGE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC4	NP_609698.2	None
Megf10	NP_001094127.1	EMI	32..99	CDD:400092	15/66 (23%)
		EGF_Lam	281..318	CDD:214543	9/49 (18%)
		EGF_CA	542..587	CDD:419698
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810