DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NimC4 and Megf8

DIOPT Version :9

Sequence 1:NP_609698.2 Gene:NimC4 / 34824 FlyBaseID:FBgn0260011 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_001153872.1 Gene:Megf8 / 269878 MGIID:2446294 Length:2789 Species:Mus musculus


Alignment Length:343 Identity:72/343 - (20%)
Similarity:104/343 - (30%) Gaps:154/343 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 VREC-CPGYLQVE--SGLCEPI------CSRGCPAHASCAAPDRCECISGYVSARNH-------- 121
            :::| .|.||.:.  :|.|..:      ||.||.....||.     |:     .|.|        
Mouse  2033 LQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCAL-----CL-----RRPHCGWCAWGG 2087

  Fly   122 QDGSHYCEP----------ICETP--------CPAGAQCV--------TPN--------TCACRD 152
            |||..:|..          .|..|        ||...:|.        |.|        .|:|:.
Mouse  2088 QDGGGHCMEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKT 2152

  Fly   153 GYTQLQPTDDGVSGGCAPVCRVGDGCANGKCIDVDRCACNSGY---------RWDKAE------- 201
            |||.     |.|:|.|.|||  ..||.||.|::.|.|.|:.|:         |.::..       
Mouse  2153 GYTM-----DNVTGVCRPVC--AQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGA 2210

  Fly   202 ----------------ERCIELSAESI-------------------------------------- 212
                            |:|:.|...|.                                      
Mouse  2211 QDHCLLCRNHTKGSHCEQCLPLFVGSALGGGTCRPCHAFCRGNSHVCVSRKELEMARKEPEKYSL 2275

  Fly   213 -SEELETTEDNTDSPSTSSTAVFTATH---------CPDDFVLFRGECREKQFDSNDVGCLK--- 264
             .||:||..  .:.||..........:         |...:.|..|:|.:.|.:.:...|.:   
Mouse  2276 DPEEIETWV--AEGPSEDEAVCVNCQNNSYGDRCESCLHGYFLLDGKCTKCQCNGHADTCNEQDG 2338

  Fly   265 SGCGPHQTCLDSGVCQCS 282
            :|| |.|...::|.||.|
Mouse  2339 TGC-PCQNNTETGTCQGS 2355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimC4NP_609698.2 None
Megf8NP_001153872.1 CUB 49..139 CDD:238001
PLN02153 203..484 CDD:177814
Kelch_4 227..276 CDD:290154
KELCH repeat 228..275 CDD:276965
Kelch 1 241..287
KELCH repeat 279..331 CDD:276965
Kelch 2 290..338
Kelch 3 346..399
Kelch 4 402..453
KELCH repeat 448..510 CDD:276965
Kelch 5 459..511
Kelch 6 525..575
PSI 950..998 CDD:279745
vWFA 1011..>1035 CDD:294047
EGF_3 1078..1112 CDD:289699
EGF_Lam 1210..1259 CDD:238012
Kelch 7 1522..1570
PLN02153 <1540..1763 CDD:177814
KELCH repeat 1566..1612 CDD:276965
Kelch 8 1580..1629
KELCH repeat 1621..1668 CDD:276965
Kelch_3 1630..1680 CDD:290151
Kelch 9 1632..1679
KELCH repeat 1673..1721 CDD:276965
Kelch 10 1685..1735
Kelch_6 1728..1775 CDD:290672
KELCH repeat 1729..1773 CDD:276965
Kelch 11 1740..1787
Kelch 12 1796..1841
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2468..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2762..2789
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6531
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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