DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NimC4 and MEGF8

DIOPT Version :9

Sequence 1:NP_609698.2 Gene:NimC4 / 34824 FlyBaseID:FBgn0260011 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_001258867.1 Gene:MEGF8 / 1954 HGNCID:3233 Length:2845 Species:Homo sapiens


Alignment Length:341 Identity:72/341 - (21%)
Similarity:107/341 - (31%) Gaps:150/341 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 VREC-CPGYLQVE--SGLCEPI------CSRGCPAHASCAAPDRCECISGYVSARNH-------- 121
            :::| .|.||.:.  :|.|..:      ||.||.....||.     |:     .|.|        
Human  2089 LQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCAL-----CL-----RRPHCGWCAWGG 2143

  Fly   122 QDGSHYCEP----------ICETP--------CPAGAQCV--------TPN--------TCACRD 152
            |||...|..          .|..|        ||...:|.        |.|        .|:|:.
Human  2144 QDGGGRCMEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKT 2208

  Fly   153 GYTQLQPTDDGVSGGCAPVCRVGDGCANGKCIDVDRCACNSGY---------RWDKAE------- 201
            |||.     |.::|.|.|||  ..||.||.|::.|.|.|:.|:         |.::..       
Human  2209 GYTM-----DNMTGLCRPVC--AQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGA 2266

  Fly   202 ----------------ERCIELSAES---------------------IS-EELETTEDN------ 222
                            |:|:.|...|                     || :||:.::..      
Human  2267 RDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSL 2331

  Fly   223 ---------TDSPSTSSTAVFTATH---------CPDDFVLFRGECREKQFDSNDVGCLK---SG 266
                     |:.||..........:         |...:.|..|:|.:.|.:.:...|.:   :|
Human  2332 DPEEIENWVTEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTG 2396

  Fly   267 CGPHQTCLDSGVCQCS 282
            | |.|...::|.||.|
Human  2397 C-PCQNNTETGTCQGS 2411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimC4NP_609698.2 None
MEGF8NP_001258867.1 CUB 49..139 CDD:238001
Kelch_4 227..276 CDD:290154
KELCH repeat 228..275 CDD:276965
Kelch 1 241..287
KELCH repeat 279..331 CDD:276965
Kelch 2 290..338
Kelch 3 346..399
Kelch 4 402..453
KELCH repeat 448..510 CDD:276965
Kelch 5 459..511
Kelch 6 525..575
PSI 950..998 CDD:279745
vWFA 1011..>1035 CDD:294047
EGF_3 1078..1112 CDD:289699
EGF_Lam 1210..1259 CDD:238012
Kelch 7 1522..1570
KELCH repeat 1566..1612 CDD:276965
Kelch 8 1580..1626
KELCH repeat 1620..1669 CDD:276965
Kelch_3 1630..1680 CDD:290151
Kelch 9 1632..1679
KELCH repeat 1672..1720 CDD:276965
Kelch 10 1685..1735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1726..1745
KELCH repeat 1785..1838 CDD:276965
Kelch 11 1796..1843
Kelch 12 1852..1898
Plasmod_Pvs28 <2189..2314 CDD:283826 27/131 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2523..2564
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2817..2845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6531
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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