DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC4 and Stab1

DIOPT Version :9

Sequence 1:	NP_609698.2	Gene:	NimC4 / 34824	FlyBaseID:	FBgn0260011	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_619613.2	Gene:	Stab1 / 192187	MGIID:	2178742	Length:	2571	Species:	Mus musculus

Alignment Length:	454	Identity:	100/454 - (22%)
Similarity:	137/454 - (30%)	Gaps:	173/454 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LILVLGS---IAANAERDNYCERNETIRATVPVTKQRIIVKQPSKWKIWKKT--EKI-------- 58
            |:|.|..   |.....|...|:.:.......|.|....|.:|...|. |.:.  |||
Mouse    13 LVLCLSDSSFIRGQTVRSKRCDIHTKFVTHTPCTACAAIRRQLCPWG-WSRNFPEKILLDCRYEL 76

  Fly    59 ------TEIYDSEEEQVTHRLVRECCPGY-----LQVESGLCEPICSRG-------------CPA 99
                  ..:....:|.....:.:.|||||     .:...|...|....|             |..
Mouse    77 QLRGAAISLSGCSQECWKDVVQKACCPGYWGSQCFECPGGPATPCSGHGTCLDGIEGNGTCVCQE 141

  Fly   100 HAS------CAAPDR--------CECISGYVSARNHQDGS---------HYCE---PICET-PCP 137
            :.|      |..|:|        |.|:.|..|.....|||         .:|:   |:|:: .||
Mouse   142 NFSGSVCQECRDPNRFGPDCQSVCNCVHGVCSHGPRGDGSCRCFAGYTGPHCDQELPVCQSLKCP 206

  Fly   138 AGAQC-VTPNTCACRDGYTQLQPTDDGVSGGCAPVCRVGDGCANGKCIDVDRCA----------C 191
            ..:|| ....||.|..||||    .|.       ||...|.|....|..:.||:          |
Mouse   207 QNSQCSAEAPTCKCLPGYTQ----QDN-------VCLAPDPCQPSACSPLARCSVTPQGQAQCQC 260

  Fly   192 NSGYRWDKAEERCIELSAESISEELETTEDNTDSPSTSSTAVFTATHCPDD--FVLFRGE----- 249
            ...|..|  .:.|:                    |.......|..  ||.:  |.|:||.
Mouse   261 PENYHGD--GKVCL--------------------PRDPCLTNFGG--CPSNSTFCLYRGPGKATC 301

  Fly   250 -CREKQFDSND---VGCLKSGCGPHQTCLDSGVCQ----------CSDGYVPEESGEATGVLSCR 300
             ||......|:   .||..| |.|| :|..|..||          |.:    :|.|:..   :|.
Mouse   302 MCRPGMTSINNNASEGCHVS-CKPH-SCDRSATCQVTPDRKTSCVCKN----DEVGDGH---ACY 357

  Fly   301 RTLLDQILGLNEAIDDDDELNPWTIPIIGVACGFLFVLLIVGLLGGRRYRQERAALANKEMECQ 364
            ..||.::...|:.                   |.:|:.|             |||:|..|..||
Mouse   358 GHLLHEVRRANQN-------------------GLVFLRL-------------RAAIAMLEQGCQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
NimC4	NP_609698.2	None
Stab1	NP_619613.2	Fasciclin	520..644	CDD:280607
		EGF_3	915..946	CDD:289699
		EGF_3	952..988	CDD:289699
		Fasciclin	1000..1121	CDD:280607
		EGF_3	1460..1496	CDD:289699
		EGF_3	1502..1539	CDD:289699
		EGF_3	1545..1582	CDD:289699
		Fasciclin	1607..1711	CDD:280607
		Fasciclin	1737..1867	CDD:280607
		EGF_Lam	<1992..2021	CDD:214543
		EGF_3	2095..2130	CDD:289699
		EGF_3	2136..2173	CDD:289699
		Link_Domain	2208..2300	CDD:295393
		FAS1	2367..2463	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900