DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and TRIL

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_055632.2	Gene:	TRIL / 9865	HGNCID:	22200	Length:	811	Species:	Homo sapiens

Alignment Length:	340	Identity:	104/340 - (30%)
Similarity:	157/340 - (46%)	Gaps:	26/340 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQY 91
            |.|..:.::.||..|.|        ||          .:|...|..:.::::..|..:.|.:|:.
Human    41 CTNRGLRVVPKTSSLPS--------PH----------DVLTYSLGGNFITNITAFDFHRLGQLRR 87

  Fly    92 LSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFD 156
            |.|.:|.:.||...:.|.|..|..|.|.:|:|..|:..:.....:|:.|....|.||::...||:
Human    88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFE 152

  Fly   157 GLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQN-LLS 220
            ||..|..|.|:||.|..:..:.|..|..|..|.|:.|||.|:..::|.....||.|.|..| |..
Human   153 GLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217

  Fly   221 SLQ----FLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSL 281
            ||:    |...|.|:.|:   ||:|.||.|.|.:|.....|..|.|..|.:|.|..||..||::|
Human   218 SLRHAATFAPLRSLSSLI---LSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEAL 279

  Fly   282 ERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQM 346
            ..|.:..|.:.::....|:.|.:|..||:|.|.|:.|....|....:|.|:.|.||.:..:|..:
Human   280 RELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344

  Fly   347 MFNQNHLRYIKLSGN 361
            ......|..:.|.||
Human   345 FAASPALYRLDLDGN 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	4/22 (18%)
		LRR_8	64..123	CDD:290566	16/58 (28%)
		leucine-rich repeat	65..88	CDD:275380	4/22 (18%)
		leucine-rich repeat	89..112	CDD:275380	8/22 (36%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		LRR_RI	115..384	CDD:238064	83/252 (33%)
		LRR_8	135..195	CDD:290566	21/59 (36%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	23/63 (37%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..232	CDD:275380	11/27 (41%)
		LRR_8	232..289	CDD:290566	21/56 (38%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	10/22 (45%)
		LRR_8	280..339	CDD:290566	18/58 (31%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
TRIL	NP_055632.2	LRR_RI	<2..194	CDD:238064	49/170 (29%)
		leucine-rich repeat	37..61	CDD:275380	8/37 (22%)
		LRR 1	61..81		3/19 (16%)
		leucine-rich repeat	62..84	CDD:275380	4/21 (19%)
		LRR_8	84..143	CDD:290566	17/58 (29%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	8/22 (36%)
		LRR 3	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	9/22 (41%)
		LRR_8	156..215	CDD:290566	21/58 (36%)
		LRR 5	156..177		7/20 (35%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR 6	180..201		8/20 (40%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR 7	204..223		8/18 (44%)
		leucine-rich repeat	205..254	CDD:275380	20/51 (39%)
		LRR 8	230..251		10/23 (43%)
		LRR_8	239..289	CDD:290566	19/49 (39%)
		LRR_RI	<249..>364	CDD:238064	34/111 (31%)
		LRR 9	254..275		8/20 (40%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		LRR 10	278..299		4/20 (20%)
		LRR_8	279..337	CDD:290566	18/57 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR 11	302..323		8/20 (40%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		LRR 12	326..347		6/20 (30%)
		leucine-rich repeat	327..346	CDD:275380	6/18 (33%)
		leucine-rich repeat	351..363	CDD:275378	4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..549
		fn3	589..667	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840