Protein Alignment CG18095 and LGI1

DIOPT Version :10

• Sequence 1: NP_001188805.1
• Gene: CG18095 / 34823
• FlyBaseID: FBgn0028872
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005088.1
• Gene: LGI1 / 9211
• HGNCID: 6572
• Length: 557
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 66/291 - (22%)
• Similarity: 116/291 - (39%)
• Gaps: 47/291 - (16%)

  Fly   115 NLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFF 179
            :|....:..:::|..||...|.||.|....|....|.:|:|.||.||::|::..|.:..|....|
Human    71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTF 135

  Fly   180 RGLHRLSSLSLQHNRIEFIEMDSFE-----SNTHLR--SLRLDQNLLSSLQFLSQRGLARLVHLN 237
            |||..|..|||.:|.::.:..|.|:     :|..||  |...|..|...:::|.        |.|
Human   136 RGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLG--------HTN 192

  Fly   238 LSSNLLQKLEPFVFSK----NFELQDLDLSYNNITK---LNKEALSGLDSLERLN---------- 285
            .:...:....|..:.|    :...:|.|.......|   |..::|| :|:...||
Human   193 ATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS-IDTFSYLNDEYVVIAQPF 256

  Fly   286 ------ISHNYVDKI---YDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANN--KI 339
                  :..::|:|.   ||....:...:.:..:....|..:...||..:...:....||.  ||
Human   257 TGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKI 321

  Fly   340 EEISSQMMFNQNHLRYIKLSGN---AISDAA 367
            ::|....:...|.:...|:..|   .::|::
Human   322 QDIEILKIRKPNDIETFKIENNWYFVVADSS 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	LRR	22..>338	CDD:443914	59/257 (23%)
		leucine-rich repeat	41..64	CDD:275380
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380	4/20 (20%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	8/27 (30%)
		leucine-rich repeat	209..232	CDD:275380	6/24 (25%)
		leucine-rich repeat	233..256	CDD:275380	4/26 (15%)
		leucine-rich repeat	257..280	CDD:275380	6/25 (24%)
		leucine-rich repeat	281..304	CDD:275380	6/41 (15%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
LGI1	NP_005088.1	leucine-rich repeat	71..92	CDD:275378	4/20 (20%)
		LRR_8	91..151	CDD:404697	24/59 (41%)
		LRR 1	92..113		7/20 (35%)
		leucine-rich repeat	93..116	CDD:275378	9/22 (41%)
		LRR 2	116..137		6/20 (30%)
		leucine-rich repeat	117..140	CDD:275378	8/22 (36%)
		LRR 3	140..161		7/20 (35%)
		leucine-rich repeat	141..164	CDD:275378	7/22 (32%)
		PCC	146..>221	CDD:188093	16/82 (20%)
		leucine-rich repeat	165..177	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	225..267		7/42 (17%)
		EPTP	225..265	CDD:461033	7/40 (18%)
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	271..313		5/41 (12%)
		EPTP	272..310	CDD:461033	5/37 (14%)
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	317..364		7/36 (19%)
		EPTP	317..362	CDD:461033	7/36 (19%)
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	366..415
		EPTP	366..413	CDD:461033
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	419..462
		EPTP	420..460	CDD:461033
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	464..506
		EPTP	465..504	CDD:461033
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..550	CDD:461033