DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Cpn2

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	534	Identity:	133/534 - (24%)
Similarity:	225/534 - (42%)	Gaps:	89/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNG---LTKLQYLSLSHNNLSSLRSWSSEP---- 109
            ||:.:..||           .:..:.:...:.:|   |||:.:|:....:|        ||
Mouse    49 PHITDIVFV-----------ETAFTTVRTRAFSGSPNLTKVVFLNTQVRHL--------EPDAFG 94

  Fly   110 -LGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAH 173
             |..|.:|:::.:.:|.||...|.....|::|.|.::|::.:..|.|..:..|:.|.|.||||..
Mouse    95 GLPRLQDLEITGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPEDLFCHMDILESLQLQGNQLRT 159

  Fly   174 IDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNL 238
            :.|..|:.|..|.:|:|..|.:..:...:|:|.|.|:.|:|..|:|:.|...:...|:.|..|.|
Mouse   160 LPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLTGLQMLKLSNNMLARLPEGALGSLSSLQELFL 224

  Fly   239 SSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLI 303
            ..|.:.:|.|.:||:.|.|:.|.|.:|.|..|.....|.|.:|..|::..|.:..:.:.......
Mouse   225 DGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLKDNALRTLPEGLFAHNQ 289

  Fly   304 ALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAF 368
            .||.|.:|:|.|.|:|:..|...::|..:.|::|.|.::...:..|...|  :|||.::.:..|.
Mouse   290 GLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNAITDLPEHVFRNLEQL--VKLSLDSNNLTAL 352

  Fly   369 LDRLSPSVNRFTLYVDLSSNRLKSLNLSSLLHFRY--INLA--DNNWSCNWLVANLVQKLPNSVN 429
            ...|..:::|..| ::||.|:|.:|. ..:....|  .|||  .|.|.|:..::.|...|
Mouse   353 HPALFHNLSRLQL-LNLSRNQLTTLP-GGIFDTNYDLFNLALLGNPWQCDCHLSYLTSWL----- 410

  Fly   430 FARPWTVINNLSENT-TNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPL 493
                 .:.||...|| |...|...::|..           ||..|.:...|.|       :|..|
Mouse   411 -----RLYNNQISNTHTFCAGPAYLKGQL-----------VPNLKQEQLICPV-------NPGHL 452

  Fly   494 TWPKIPTDRFDSRSVIIWML-------------------VAIAIAFSGLRWLRRFVDRNEKRKLG 539
            ::..:..|  :......|.|                   |.:|...|..|||...:...:    |
Mouse   453 SFRALGLD--EGEPAGSWDLTVEGRAAHSQCAYSNPEGTVLLACEESRCRWLNIQLSSRD----G 511

  Fly   540 QKMLHNVYVSKVQW 553
            ......||.|..:|
Mouse   512 SDSAAMVYNSSQEW 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	4/11 (36%)
		LRR_8	64..123	CDD:290566	11/66 (17%)
		leucine-rich repeat	65..88	CDD:275380	2/25 (8%)
		leucine-rich repeat	89..112	CDD:275380	5/27 (19%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		LRR_RI	115..384	CDD:238064	77/268 (29%)
		LRR_8	135..195	CDD:290566	20/59 (34%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		LRR_8	184..243	CDD:290566	18/58 (31%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	19/56 (34%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		LRR_8	280..339	CDD:290566	15/58 (26%)
		leucine-rich repeat	281..304	CDD:275380	3/22 (14%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	2/2 (100%)
		LRR_8	73..133	CDD:290566	17/67 (25%)
		leucine-rich repeat	75..98	CDD:275380	8/30 (27%)
		LRR 1	98..119		6/20 (30%)
		leucine-rich repeat	99..122	CDD:275380	6/22 (27%)
		LRR_8	121..181	CDD:290566	20/59 (34%)
		LRR 2	122..143		6/20 (30%)
		leucine-rich repeat	123..146	CDD:275380	6/22 (27%)
		LRR 3	146..167		9/20 (45%)
		leucine-rich repeat	147..170	CDD:275380	10/22 (45%)
		LRR_RI	149..374	CDD:238064	68/227 (30%)
		LRR 4	170..191		5/20 (25%)
		LRR_8	171..229	CDD:290566	18/57 (32%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 5	194..215		6/20 (30%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR_8	217..277	CDD:290566	20/59 (34%)
		LRR 6	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 7	242..263		6/20 (30%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		LRR_8	266..325	CDD:290566	15/58 (26%)
		LRR 8	266..287		3/20 (15%)
		leucine-rich repeat	267..290	CDD:275380	3/22 (14%)
		LRR 9	290..311		9/20 (45%)
		leucine-rich repeat	291..314	CDD:275380	9/22 (41%)
		LRR_8	313..373	CDD:290566	16/62 (26%)
		LRR 10	314..335		4/20 (20%)
		leucine-rich repeat	315..338	CDD:275380	5/22 (23%)
		LRR 11	338..359		6/22 (27%)
		leucine-rich repeat	339..360	CDD:275380	6/22 (27%)
		LRR 12	362..383		7/22 (32%)
		leucine-rich repeat	363..382	CDD:275380	6/20 (30%)
		LRRCT	395..436	CDD:214507	12/61 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840