DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and aspn

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_571788.2	Gene:	aspn / 65228	ZFINID:	ZDB-GENE-041105-7	Length:	370	Species:	Danio rerio

Alignment Length:	408	Identity:	96/408 - (23%)
Similarity:	153/408 - (37%)	Gaps:	124/408 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LLTSLTLSNC-TLPHVENGFFVRFDHLLHLELQHSG------------LSDLDDFSLNGLT---- 87
            ||..|||.|. ...|:....|::...::.   |.:|            ..|.||:..|.:|
Zfish     6 LLALLTLCNAKPYKHINVMEFMKHHDIMQ---QDAGDFDDDDDDDDDDDKDYDDYDDNFVTDCPE 67

  Fly    88 ----KLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRIS 148
                ..:.|..|...|:.:..            |:..|.|               .|||:.|.|:
Zfish    68 GCRCSKKVLQCSDQGLTKVPK------------DIPANTL---------------LLDLQNNDIT 105

  Fly   149 QIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLR 213
            :|:.|.|.||.:|..|:|..||::.|....||.:::|..|.|.:|.:                .:
Zfish   106 EIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLL----------------TQ 154

  Fly   214 LDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGL 278
            :.:||..|:|           .|.|..|.:.:|....|....:|..|:||.|.||.      ||:
Zfish   155 MPENLPISVQ-----------SLRLHDNKISRLPKGAFKGMHDLNVLELSANPITN------SGI 202

  Fly   279 D----------------------------SLERLNISHNYVDKIYDESLDSLIALLQLDISFNLL 315
            |                            ||..|::.:|.:.|:..|....|..|.:|.:.||.:
Zfish   203 DVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQI 267

  Fly   316 TTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIK---LSGNAISDAAFLDRLSPSVN 377
            ..:.:..|....::.||.|.|||:::|...:    |.|:|::   |..|:|......| ..||..
Zfish   268 KYVENGTFAATPKVREIHLDNNKLKKIPPGL----NTLKYLQVMYLHANSIGYVGVND-FCPSRT 327

  Fly   378 RF--TLY--VDLSSNRLK 391
            |.  .||  :.|.:|.:|
Zfish   328 RAKKALYTRISLYANPVK 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/23 (30%)
		LRR_8	64..123	CDD:290566	12/78 (15%)
		leucine-rich repeat	65..88	CDD:275380	7/42 (17%)
		leucine-rich repeat	89..112	CDD:275380	3/22 (14%)
		leucine-rich repeat	113..136	CDD:275380	3/22 (14%)
		LRR_RI	115..384	CDD:238064	75/303 (25%)
		LRR_8	135..195	CDD:290566	22/59 (37%)
		leucine-rich repeat	137..160	CDD:275380	10/22 (45%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	11/58 (19%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		LRR_8	232..289	CDD:290566	18/84 (21%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..280	CDD:275380	10/50 (20%)
		LRR_8	280..339	CDD:290566	17/58 (29%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	5/22 (23%)
aspn	NP_571788.2	LRRNT	64..94	CDD:214470	4/41 (10%)
		leucine-rich repeat	74..93	CDD:275380	4/30 (13%)
		leucine-rich repeat	94..117	CDD:275380	11/37 (30%)
		LRR_8	97..152	CDD:290566	22/54 (41%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR_RI	<133..323	CDD:238064	51/227 (22%)
		leucine-rich repeat	142..162	CDD:275380	6/35 (17%)
		LRR_8	162..243	CDD:290566	21/97 (22%)
		leucine-rich repeat	163..186	CDD:275380	6/33 (18%)
		leucine-rich repeat	187..212	CDD:275380	10/30 (33%)
		leucine-rich repeat	213..232	CDD:275380	0/18 (0%)
		LRR_8	231..291	CDD:290566	17/59 (29%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..323	CDD:275380	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100