DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and flrt2

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001093513.1	Gene:	flrt2 / 571972	ZFINID:	ZDB-GENE-070705-267	Length:	662	Species:	Danio rerio

Alignment Length:	601	Identity:	136/601 - (22%)
Similarity:	212/601 - (35%)	Gaps:	215/601 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQH 72
            ||.|...|||..||.:..:|:.|.|....::  |||:.|.      |:.|:...|.|  :.::.:
Zfish    23 LLSLHVQFSPVSSCPEECRCDRTFVYCNERS--LTSVPLG------VQEGYKTLFLH--NNQINN 77

  Fly    73 SGL-----------------SDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSH 120
            :|.                 :.||:|.||....::.|.|..||:.::...:...|..|..|.|..
Zfish    78 AGFPLELHNVASVETVYLYGNQLDEFPLNLPKNVRVLHLQENNIQTISRAALAQLHMLEELHLDD 142

  Fly   121 NMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHR- 184
            |.:|.:.|                      |..:|.....||.|:|..|.|:.|.    .||..
Zfish   143 NSISTVGV----------------------EEGAFREALSLKLLFLTKNHLSSIP----IGLPAD 181

  Fly   185 LSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPF 249
            |..|.|..|||..|:.|:|::.|.|:.|.||.|||..                      :.:.|.
Zfish   182 LKELRLDENRIADIDEDAFQNVTTLQRLLLDGNLLED----------------------EAIAPG 224

  Fly   250 VFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNL 314
            .|.....|::|.|:.|::|.  ...|....||.:||:..|.:|.|...:...|..|.:||||.||
Zfish   225 TFQDLVNLKELSLARNSLTA--PPPLLPSVSLTKLNLQENQIDTIEVTAFAGLSKLEKLDISNNL 287

  Fly   315 LTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRF 379
            |..||..:|
Zfish   288 LQILPPGVF-------------------------------------------------------- 296

  Fly   380 TLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSCN----WLVANLVQKLPNSVNFARPWT----- 435
                    :.|:||        |.:|..:|.|.|:    |::|.| :.||:::| .|.:|
Zfish   297 --------DGLRSL--------RILNARNNLWRCDCSIKWVIAWL-RSLPSAIN-VRGFTCQSPE 343

  Fly   436 -----VINNLSENTTNVEGIDCIEG-------------------------GTNRSIILLDVSGVP 470
                 ||..|:     ::.|||..|                         .|:|:..:..:|...
Zfish   344 RVRGMVIRELT-----LDAIDCPAGTVLHPWPTHTYPSTLPPRRTSTITKTTSRTTRITTISPTA 403

  Fly   471 -QPKSDNCDCVVAYDETNPSPPPLTWPKIPTDRFDSRSVIIWMLV-AIAIAFSGLRWLRRFVDRN 533
             .|.|           |||:||...:|..|...::....|.:.:| :..|..|   |...|...:
Zfish   404 FYPAS-----------TNPTPPVPHFPPGPLPPYEDPLKISFHVVNSTCIDVS---WESYFTVTS 454

  Fly   534 EK---RKLGQKMLHNV 546
            .|   .|:||.::.::
Zfish   455 YKVTWVKMGQSLMSDI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/22 (32%)
		LRR_8	64..123	CDD:290566	16/75 (21%)
		leucine-rich repeat	65..88	CDD:275380	6/39 (15%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		LRR_RI	115..384	CDD:238064	60/269 (22%)
		LRR_8	135..195	CDD:290566	15/60 (25%)
		leucine-rich repeat	137..160	CDD:275380	2/22 (9%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		LRR_8	184..243	CDD:290566	17/59 (29%)
		leucine-rich repeat	185..208	CDD:275380	9/22 (41%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	12/56 (21%)
		leucine-rich repeat	233..256	CDD:275380	2/22 (9%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		LRR_8	280..339	CDD:290566	19/58 (33%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	11/22 (50%)
flrt2	NP_001093513.1	LRRNT	36..62	CDD:214470	8/33 (24%)
		leucine-rich repeat	45..65	CDD:275378	7/27 (26%)
		leucine-rich repeat	66..89	CDD:275378	3/24 (13%)
		leucine-rich repeat	90..110	CDD:275380	5/19 (26%)
		LRR_8	109..171	CDD:290566	18/83 (22%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		LRR_RI	114..310	CDD:238064	71/317 (22%)
		leucine-rich repeat	135..160	CDD:275380	8/46 (17%)
		leucine-rich repeat	161..181	CDD:275380	9/23 (39%)
		LRR_8	182..242	CDD:290566	23/81 (28%)
		leucine-rich repeat	182..205	CDD:275380	9/22 (41%)
		leucine-rich repeat	206..231	CDD:275380	9/46 (20%)
		leucine-rich repeat	232..253	CDD:275380	6/22 (27%)
		LRR_8	253..311	CDD:290566	24/129 (19%)
		leucine-rich repeat	254..277	CDD:275380	7/22 (32%)
		leucine-rich repeat	278..301	CDD:275380	12/86 (14%)
		TPKR_C2	310..361	CDD:301599	16/57 (28%)
		fn3	429..503	CDD:278470	10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100