DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and igfals

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	498	Identity:	133/498 - (26%)
Similarity:	225/498 - (45%)	Gaps:	58/498 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPGSLLLLIFSFSPR----LSCLQLSKCNNTEVT--LIRKTELLTSLTLSNCTLPHVENGFFVRF 62
            |..|||:.:.:.:.|    |:.|.|.:.|...::  :.:.|..|.:|:|:|..:..:::..|...
Zfish   113 LQSSLLVSLDAHAFRGLNSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFAGM 177

  Fly    63 DHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLS 127
            .|:..|.|..:.||.|.:.....|..|:.|.|:.|.|:.|:....:.|..|..|||:.|.|..:.
Zfish   178 SHMWLLNLGWNLLSVLPETGFQDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIK 242

  Fly   128 VKSFEQYPQLQQ------------------------LDLRYNRISQIENDSFDGLSHLKHLYLNG 168
            ...|.:.|:||:                        |||..||::.:.:::|.||..|..|.|:.
Zfish   243 ANVFLKLPKLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLTVLHDETFIGLQSLHVLRLSN 307

  Fly   169 NQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARL 233
            |.:..:....||.|..|..|.|.||:|..:.:..||...||..|.|:.|.|...:..:..||..|
Zfish   308 NSINSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHL 372

  Fly   234 VHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDES 298
            ..:.|:.:....|...||....:|..:.|..:.:||::.::.|||..|.||.:.||.:..:..:|
Zfish   373 AVMKLTGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFLQHNNISLVERQS 437

  Fly   299 LDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAI 363
            ...|..|.|||:.||.|||:..|.|:....|:.::|:.|.:..:.::.:....||.::.||||.:
Zfish   438 FVELQRLQQLDLRFNKLTTITSNTFYGLKNLDYLLLSGNLLHNLPAEALLPLQHLSWLDLSGNKL 502

  Fly   364 -----SDAAFLDRLSPSVNRFTLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSCNW-------L 416
                 :....|.||.        |::|..|.|.:|.:|.......:.|:.|||.|:.       .
Zfish   503 ELILNATIYMLPRLR--------YLNLKDNILVNLPVSIPESLDQLWLSGNNWKCDCSAKPFRDF 559

  Fly   417 VANLVQKLPNSVNF----ARPWTVI---NNLS-ENTTNVEGID 451
            :....|.:|..|..    ..|.|:|   ||:: .:.::..|:|
Zfish   560 ILQKPQVVPLQVEMLGEGEEPHTLITVYNNVTCASPSSASGLD 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/22 (23%)
		LRR_8	64..123	CDD:290566	19/58 (33%)
		leucine-rich repeat	65..88	CDD:275380	6/22 (27%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	83/297 (28%)
		LRR_8	135..195	CDD:290566	23/83 (28%)
		leucine-rich repeat	137..160	CDD:275380	10/46 (22%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	18/58 (31%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	15/56 (27%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		LRR_8	280..339	CDD:290566	21/58 (36%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	11/22 (50%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764
		leucine-rich repeat	65..83	CDD:275380
		leucine-rich repeat	84..107	CDD:275380
		LRR_8	85..142	CDD:290566	8/28 (29%)
		leucine-rich repeat	108..131	CDD:275380	5/17 (29%)
		LRR_8	131..214	CDD:290566	21/82 (26%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..203	CDD:275380	12/46 (26%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_RI	<219..456	CDD:238064	68/236 (29%)
		LRR_8	227..286	CDD:290566	14/58 (24%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	2/22 (9%)
		LRR_8	274..334	CDD:290566	20/59 (34%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	8/22 (36%)
		leucine-rich repeat	348..369	CDD:275380	5/20 (25%)
		LRR_8	371..430	CDD:290566	17/58 (29%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	418..478	CDD:290566	21/59 (36%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	11/22 (50%)
		LRR_8	466..524	CDD:290566	14/65 (22%)
		leucine-rich repeat	468..486	CDD:275380	3/17 (18%)
		leucine-rich repeat	492..515	CDD:275380	6/22 (27%)
		leucine-rich repeat	516..540	CDD:275380	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF9C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770