DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and flrt3

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001243575.1	Gene:	flrt3 / 558864	ZFINID:	ZDB-GENE-030131-1988	Length:	649	Species:	Danio rerio

Alignment Length:	550	Identity:	130/550 - (23%)
Similarity:	221/550 - (40%)	Gaps:	140/550 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YLLPGSLLLLIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTL---SNCTLPHVENGFFVRFD 63
            ::..|.||.|........||....:|:.|.:....:.  |||:..   .:.|:..::|.
Zfish    12 FIRAGLLLGLANPLMTSASCPSQCRCDGTFIYCNDRD--LTSIPSGIPEDATVLFLQNN------ 68

  Fly    64 HLLHLELQHSGL-SDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLS 127
                 .::.:|: :||.  .|||:.|: ||..  |||....  ::.||. :..|.|..|.:..::
Zfish    69 -----RIKSAGIPTDLR--RLNGVEKI-YLYC--NNLDEFP--TNLPLN-VKELHLQENNIRTIT 120

  Fly   128 VKSFEQYPQLQQLDLRYNRIS--QIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGL-HRLSSLS 189
            ..|..|.|.:::|.|..|.:|  .||..:|...:||:.|:|:.|.|:.|..    || ..:..|.
Zfish   121 HASLAQIPFIEELHLDDNSVSAVSIEEGAFRDSNHLRLLFLSRNHLSTIPS----GLPMTIEELR 181

  Fly   190 LQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKN 254
            ...|||..|...|.:...:|:.|.||.|||::      ||:..:..:||
Zfish   182 FDDNRISSISEASLQDLINLKRLVLDGNLLNN------RGIGEMALVNL---------------- 224

  Fly   255 FELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLP 319
            ..|.:|.|..|::|. ....|.| .|||:||:..|:::.:...:...|..|.:||:|.|.|::||
Zfish   225 VNLTELSLVRNSLTS-PPANLPG-SSLEKLNLQDNHINHVPPGAFAFLRQLYRLDLSGNNLSSLP 287

  Fly   320 DNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYI---------------KLSGNAISD---- 365
            ..:|.....|.:::|.||. ...:.:|.:.::.||.:               |:.|.||.|
Zfish   288 MGVFEDLDNLTQLLLRNNP-WHCNCRMKWVRDWLRTLPSKVNVRGFMCQGPDKVKGMAIKDLSTE 351

  Fly   366 ---------------AAFLDRLSPSVNRFTLYV---------DL---------SSNRLKSLNLSS 397
                           :...:.|.||..::..||         ||         ||.::.::::.|
Zfish   352 LFGCSDTEIPTTYETSTVSNTLPPSRPQWPSYVTKRPVVKGPDLGRNYRSTTPSSRKIITISVKS 416

  Fly   398 ----LLHFRY-INLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEGGT 457
                .:|..: ::........:||      ||.:|..|.         |...|.|:|
Zfish   417 SSAETVHISWRVSQPMTALRLSWL------KLGHSPAFG---------SITETIVQG-------- 458

  Fly   458 NRSIILLDVSGVPQPKSDNCDCVVAYDETN 487
            .|:..||...   :|:|....|:|..:.:|
Zfish   459 ERTEYLLTAL---EPESSYRICMVPMETSN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/25 (20%)
		LRR_8	64..123	CDD:290566	17/59 (29%)
		leucine-rich repeat	65..88	CDD:275380	6/23 (26%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	115..384	CDD:238064	79/314 (25%)
		LRR_8	135..195	CDD:290566	19/62 (31%)
		leucine-rich repeat	137..160	CDD:275380	7/24 (29%)
		leucine-rich repeat	161..184	CDD:275380	8/23 (35%)
		LRR_8	184..243	CDD:290566	17/58 (29%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	14/56 (25%)
		leucine-rich repeat	233..256	CDD:275380	2/22 (9%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		LRR_8	280..339	CDD:290566	20/58 (34%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
flrt3	NP_001243575.1	LRRNT	31..61	CDD:214470	6/31 (19%)
		leucine-rich repeat	61..84	CDD:275378	6/35 (17%)
		leucine-rich repeat	85..105	CDD:275380	7/24 (29%)
		LRR_RI	104..327	CDD:238064	70/252 (28%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..155	CDD:275380	7/24 (29%)
		LRR_8	131..211	CDD:290566	27/83 (33%)
		leucine-rich repeat	156..176	CDD:275380	8/23 (35%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		LRR_8	178..237	CDD:290566	21/80 (26%)
		leucine-rich repeat	201..226	CDD:275380	11/46 (24%)
		leucine-rich repeat	227..248	CDD:275380	7/22 (32%)
		LRR_8	247..306	CDD:290566	19/58 (33%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	9/22 (41%)
		LRRCT	305..356	CDD:214507	9/51 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100