DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18095 and ASPN

DIOPT Version :9

Sequence 1:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_060150.4 Gene:ASPN / 54829 HGNCID:14872 Length:379 Species:Homo sapiens


Alignment Length:280 Identity:75/280 - (26%)
Similarity:123/280 - (43%) Gaps:55/280 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 QQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDS 202
            :.|||:.|:|.:|:.:.|.||:.|..|.||.|:|..|....|....:|..|.|.||::..|.::.
Human   104 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNL 168

  Fly   203 FESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQK--LEPFVFS------------- 252
            .:|   |..||:.:|.:..:|..:.:|:..|..|.:|:|.|..  :||..|.             
Human   169 PKS---LAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAK 230

  Fly   253 -----KNF--ELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDI 310
                 |..  .|.:|.|.||.|:.:..|.......|:||.:.:|.:                .||
Human   231 LTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKI----------------TDI 279

  Fly   311 SFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPS 375
            ....|..:|        ::.||.|.|||:::|.|.:. ...:|:.|.|..|:|:.....| ..|:
Human   280 ENGSLANIP--------RVREIHLENNKLKKIPSGLP-ELKYLQIIFLHSNSIARVGVND-FCPT 334

  Fly   376 VNRF--TLY--VDLSSNRLK 391
            |.:.  :||  :.|.:|.:|
Human   335 VPKMKKSLYSAISLFNNPVK 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18095NP_001188805.1 leucine-rich repeat 41..64 CDD:275380
LRR_8 64..123 CDD:290566
leucine-rich repeat 65..88 CDD:275380
leucine-rich repeat 89..112 CDD:275380
leucine-rich repeat 113..136 CDD:275380
LRR_RI 115..384 CDD:238064 72/271 (27%)
LRR_8 135..195 CDD:290566 22/56 (39%)
leucine-rich repeat 137..160 CDD:275380 9/21 (43%)
leucine-rich repeat 161..184 CDD:275380 8/22 (36%)
LRR_8 184..243 CDD:290566 17/58 (29%)
leucine-rich repeat 185..208 CDD:275380 7/22 (32%)
leucine-rich repeat 209..232 CDD:275380 6/22 (27%)
LRR_8 232..289 CDD:290566 19/78 (24%)
leucine-rich repeat 233..256 CDD:275380 9/44 (20%)
leucine-rich repeat 257..280 CDD:275380 7/22 (32%)
LRR_8 280..339 CDD:290566 13/58 (22%)
leucine-rich repeat 281..304 CDD:275380 4/22 (18%)
leucine-rich repeat 305..328 CDD:275380 4/22 (18%)
ASPNNP_060150.4 LRRNT 73..103 CDD:214470
leucine-rich repeat 83..102 CDD:275380
leucine-rich repeat 103..126 CDD:275380 9/21 (43%)
LRR_8 104..161 CDD:290566 22/56 (39%)
leucine-rich repeat 127..150 CDD:275380 8/22 (36%)
LRR_RI <142..339 CDD:238064 54/225 (24%)
leucine-rich repeat 151..171 CDD:275380 6/19 (32%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..221 CDD:275380 8/24 (33%)
LRR_8 240..300 CDD:290566 20/83 (24%)
leucine-rich repeat 242..265 CDD:275380 7/22 (32%)
leucine-rich repeat 266..289 CDD:275380 8/46 (17%)
leucine-rich repeat 313..332 CDD:275380 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45712
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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