DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Lrrtm4

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_017448300.1	Gene:	Lrrtm4 / 500219	RGDID:	1560707	Length:	591	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	112/428 - (26%)
Similarity:	184/428 - (42%)	Gaps:	80/428 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDS 202
            |.|.||:|.|.:::::.|.||:.|..|||:.|.::.:|...|:|:.||..|.|..|:|.::...:
  Rat    65 QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKT 129

  Fly   203 FESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNI 267
            |....:||:|.|..|.|.:||....:||.:|:.|:|.||.|:.:...||.....|..|||.||.:
  Rat   130 FHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 194

  Fly   268 TKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNT--QLE 330
            ..|::.|.:||..|:.|::.||...||                          |..||..  .|.
  Rat   195 RSLSRNAFAGLLKLKELHLEHNQFSKI--------------------------NFAHFPRLFNLR 233

  Fly   331 EIILANNKIEEISSQMMFNQNHLRYIKLSGN---AISDAAFLDRLSPSVNRFTLYVDLSSNRLKS 392
            .|.|..|:|..:|..:.:..:.|..:.||||   ||....|  :..|::.:    ::|.||:|.:
  Rat   234 SIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTF--KCLPNLQK----LNLDSNKLTN 292

  Fly   393 LN---LSSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIE 454
            ::   :::.:....|.|:.|.|.|:..:..|...|.|          .....|:|....|...|:
  Rat   293 VSQETVNAWISLISITLSGNMWECSRSICPLFYWLKN----------FKGNKESTMICAGPKHIQ 347

  Fly   455 G-----GTNRSIILLDVSGV------------------PQPKSDNCDCVVA-YDETNPSPP---P 492
            |     ......|..||..|                  |:|.....|.:.| .:..:|||.   |
  Rat   348 GEKVSDAVETYNICSDVQVVNTERSHLAPQTPQKPPFFPKPTIFKSDAIPATLEAVSPSPGFQIP 412

  Fly   493 LT---WPKIPTDRFDSRSVIIWMLVAIAIAFSGLRWLR 527
            .|   :..:...:..:.||.:::.||:.:....:.|.|
  Rat   413 GTDHEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_RI	115..384	CDD:238064	76/250 (30%)
		LRR_8	135..195	CDD:290566	22/56 (39%)
		leucine-rich repeat	137..160	CDD:275380	9/21 (43%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	22/58 (38%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	10/22 (45%)
		LRR_8	232..289	CDD:290566	20/56 (36%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	10/22 (45%)
		LRR_8	280..339	CDD:290566	13/60 (22%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	3/24 (13%)
Lrrtm4	XP_017448300.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000