DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18095 and OMD

DIOPT Version :9

Sequence 1:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_005005.1 Gene:OMD / 4958 HGNCID:8134 Length:421 Species:Homo sapiens


Alignment Length:311 Identity:84/311 - (27%)
Similarity:140/311 - (45%) Gaps:47/311 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 LGALTNLDLSHNMLSKL-----SVKSFEQYP-QLQQLDLRYNRISQIENDSFDGLSHLKHLYLNG 168
            ||.::......|..|.:     .:|:....| .:|||.|::|.|..:..:||...:|||.:.|:.
Human    60 LGCVSECFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSH 124

  Fly   169 NQL--AHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLA 231
            |::  ..||...|..|..|..|.|:||.:|..   .|.....|..|.|..|.:|.||..:..||.
Human   125 NKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEF---PFPLPKSLERLLLGYNEISKLQTNAMDGLV 186

  Fly   232 RLVHLNLSSNLLQK--LEPFVFSKNFELQDLDLSYNNITKLNKEALSGL-DSLERLNISHNYVDK 293
            .|..|:|..|.|..  |:..:|:|..:|..|:|..|.:..:.    .|| .||..|::.:|.:..
Human   187 NLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMP----PGLPSSLMYLSLENNSISS 247

  Fly   294 IYDESLDSLIALLQLDISFNLLTTLPDNL-------------------FHFNTQLEEIILANNKI 339
            |.::..|.|..|..|.:|.|.|..:|.|:                   |:....||.:.|.||:|
Human   248 IPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEI 312

  Fly   340 EEISSQMM------FNQNHLRYIKLSGNAISD--AAFLDRLSPSVNRFTLY 382
            |:::..:|      .:.:||.||::..|.:.:  ::::....|.::  |:|
Human   313 EKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIH--TIY 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18095NP_001188805.1 leucine-rich repeat 41..64 CDD:275380
LRR_8 64..123 CDD:290566 3/12 (25%)
leucine-rich repeat 65..88 CDD:275380
leucine-rich repeat 89..112 CDD:275380 1/1 (100%)
leucine-rich repeat 113..136 CDD:275380 4/28 (14%)
LRR_RI 115..384 CDD:238064 82/306 (27%)
LRR_8 135..195 CDD:290566 23/62 (37%)
leucine-rich repeat 137..160 CDD:275380 8/22 (36%)
leucine-rich repeat 161..184 CDD:275380 8/24 (33%)
LRR_8 184..243 CDD:290566 20/58 (34%)
leucine-rich repeat 185..208 CDD:275380 7/22 (32%)
leucine-rich repeat 209..232 CDD:275380 9/22 (41%)
LRR_8 232..289 CDD:290566 17/59 (29%)
leucine-rich repeat 233..256 CDD:275380 8/24 (33%)
leucine-rich repeat 257..280 CDD:275380 6/23 (26%)
LRR_8 280..339 CDD:290566 20/77 (26%)
leucine-rich repeat 281..304 CDD:275380 6/22 (27%)
leucine-rich repeat 305..328 CDD:275380 8/41 (20%)
OMDNP_005005.1 NEL <68..>305 CDD:330839 68/243 (28%)
LRR 1 92..113 8/20 (40%)
leucine-rich repeat 94..116 CDD:275380 8/21 (38%)
LRR 2 116..129 5/12 (42%)
leucine-rich repeat 117..142 CDD:275380 8/24 (33%)
LRR 3 142..164 7/24 (29%)
leucine-rich repeat 143..163 CDD:275380 7/22 (32%)
leucine-rich repeat 164..187 CDD:275380 9/22 (41%)
LRR 4 165..184 6/18 (33%)
LRR 5 187..210 7/22 (32%)
leucine-rich repeat 188..213 CDD:275380 8/24 (33%)
LRR 6 213..233 6/23 (26%)
leucine-rich repeat 214..234 CDD:275380 6/23 (26%)
LRR 7 234..255 5/20 (25%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRR 8 258..280 7/21 (33%)
leucine-rich repeat 259..281 CDD:275380 7/21 (33%)
LRR 9 281..294 0/12 (0%)
leucine-rich repeat 282..301 CDD:275380 1/18 (6%)
LRR 10 301..321 7/19 (37%)
LRR 11 331..353 5/21 (24%)
leucine-rich repeat 332..356 CDD:275380 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..421
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45712
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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