DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and tril

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_009292463.1	Gene:	tril / 448885	ZFINID:	ZDB-GENE-131218-1	Length:	758	Species:	Danio rerio

Alignment Length:	432	Identity:	112/432 - (25%)
Similarity:	181/432 - (41%)	Gaps:	91/432 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YLLP-----GSLLLLIF----SFSP-RLSC--LQLSKCNNTEVTLIRK------TELLTSLTLSN 48
            |||.     ||.|||.|    :..| |..|  .|...|.|..:..:.|      .|.:..|:|:.
Zfish     3 YLLSNLFLFGSGLLLFFAPVCAICPERCDCQHAQHILCANRGLRAVPKAPQVEHAEDVRVLSLAG 67

  Fly    49 CTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGAL 113
            ..:.::....|:|:..|:.|.||.:.:..:...|...|:||:.|.|.:|.:|:::..:.:.|..|
Zfish    68 NFIHNISAFDFMRYGDLMRLNLQFNQIRSIHPESFKKLSKLEELFLGNNLISTIQPGTLQSLKKL 132

  Fly   114 TNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSF 178
            |.|..::|.:::...|||.....|.:|.|..|.|..::...|:||.:|..|:|..|.|..||
Zfish   133 TILYSNNNEINECIPKSFTHLNSLVKLRLDGNSIEVLKESVFEGLPNLMFLHLESNHLRRID--- 194

  Fly   179 FRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLL 243
                                      .|..||        ||.|||           ||||.|..
Zfish   195 --------------------------RNAFLR--------LSKLQF-----------LNLSDNKQ 214

  Fly   244 QKLEP-FVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQ 307
            .:|:. |:||....|:.|.::.|.|..:.......|..|.:|::|||.:.|:.:|:...|..:.:
Zfish   215 TELQDVFMFSDLKSLKTLLIAGNQIRHVGNHVFQSLKKLSKLSLSHNKISKLGNEAFKGLGRVRE 279

  Fly   308 LDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRL 372
            ..|..|.||.:|..|.....::|.:..::|.|..:......:.:||:.:||..|.:.:      |
Zfish   280 FMIDRNELTEIPAGLLDPLERIEHLDFSDNHISLVDQGAFGHLSHLKILKLKNNRLMN------L 338

  Fly   373 SPSVNRFTLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSCN 414
            |.|:        .:||       ..|.|   :.|..|||:|:
Zfish   339 SGSI--------FASN-------GGLFH---VELNGNNWTCD 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	4/22 (18%)
		LRR_8	64..123	CDD:290566	17/58 (29%)
		leucine-rich repeat	65..88	CDD:275380	6/22 (27%)
		leucine-rich repeat	89..112	CDD:275380	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	67/269 (25%)
		LRR_8	135..195	CDD:290566	15/59 (25%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	13/58 (22%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	17/57 (30%)
		leucine-rich repeat	233..256	CDD:275380	9/23 (39%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		LRR_8	280..339	CDD:290566	16/58 (28%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
tril	XP_009292463.1	LRRNT	25..56	CDD:214470	7/30 (23%)
		leucine-rich repeat	60..83	CDD:275380	4/22 (18%)
		LRR_8	84..142	CDD:290566	17/57 (30%)
		LRR_4	84..123	CDD:289563	12/38 (32%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_8	155..213	CDD:290566	27/105 (26%)
		LRR_RI	156..>358	CDD:238064	67/273 (25%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	11/59 (19%)
		leucine-rich repeat	204..228	CDD:275380	12/34 (35%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		LRR_8	259..311	CDD:290566	14/51 (27%)
		leucine-rich repeat	277..298	CDD:275380	6/20 (30%)
		LRR_8	300..358	CDD:290566	16/81 (20%)
		leucine-rich repeat	301..324	CDD:275380	3/22 (14%)
		leucine-rich repeat	325..348	CDD:275380	9/43 (21%)
		FN3	546..614	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930