DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and lum

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001002059.1	Gene:	lum / 415149	ZFINID:	ZDB-GENE-040625-24	Length:	344	Species:	Danio rerio

Alignment Length:	388	Identity:	99/388 - (25%)
Similarity:	166/388 - (42%)	Gaps:	103/388 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YLLPGSLLLLIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCT------LPHVENGFFV 60
            |.:|.:.|..:  .||  ||.|..:|.            :...|...|.      :|.|..|
Zfish    26 YYIPSAPLEGV--SSP--SCAQECECP------------INFPTAMYCNERNLKFIPIVPTG--- 71

  Fly    61 RFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSS--LRSWSSEPLGALTNLDLSHNML 123
                :.:|.||::.:.::.....:..|.|::|.|.:||::|  :::.:.:.||:|..|..|||.|
Zfish    72 ----IKYLYLQNNFIEEIKAGVFDNATDLRWLVLDNNNITSDKIQAGTIDKLGSLEKLLFSHNKL 132

  Fly   124 SK----LSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHR 184
            :|    || ||.::                              |.|.||:|.....:...|:..
Zfish   133 TKPPGSLS-KSLDE------------------------------LKLIGNKLTSFPANTLAGMEN 166

  Fly   185 LSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPF 249
            |:::.|..|::      :.||.|.                 :.:||..|:.|::|.|.|:||...
Zfish   167 LTTVHLSKNKL------TTESLTG-----------------AFKGLKSLILLDVSENKLKKLPSG 208

  Fly   250 VFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHN-YVDKIYDESLDSLIALLQLDISFN 313
            |.:   .|..|....|:|..:....|:.|..|:.|.|||| .||......:.::.:||:||:|||
Zfish   209 VPA---SLLMLYADNNDIDSIPNGYLAKLPLLQYLRISHNKLVDSGVPAGVFNVSSLLELDLSFN 270

  Fly   314 LLTTLPDNLFHFNTQLEEIILANNKIE--EISSQMMF----NQNHLRYIKLSGNAISDAAFLD 370
            .|.|:|:    .|..||.:.|..|:|.  |:::...|    |.:.||.::|.||.|:.::..|
Zfish   271 KLKTIPE----INESLEHLYLQVNEINKFELTNICRFSSPVNYSRLRTLRLDGNNITHSSMPD 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/28 (18%)
		LRR_8	64..123	CDD:290566	17/60 (28%)
		leucine-rich repeat	65..88	CDD:275380	3/22 (14%)
		leucine-rich repeat	89..112	CDD:275380	7/24 (29%)
		leucine-rich repeat	113..136	CDD:275380	11/26 (42%)
		LRR_RI	115..384	CDD:238064	72/267 (27%)
		LRR_8	135..195	CDD:290566	9/59 (15%)
		leucine-rich repeat	137..160	CDD:275380	0/22 (0%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		LRR_8	184..243	CDD:290566	12/58 (21%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	2/22 (9%)
		LRR_8	232..289	CDD:290566	18/56 (32%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		LRR_8	280..339	CDD:290566	23/59 (39%)
		leucine-rich repeat	281..304	CDD:275380	8/23 (35%)
		leucine-rich repeat	305..328	CDD:275380	11/22 (50%)
lum	NP_001002059.1	LRRNT	41..68	CDD:279764	6/38 (16%)
		LRR_RI	58..274	CDD:238064	70/279 (25%)
		LRR_8	70..132	CDD:290566	18/68 (26%)
		leucine-rich repeat	72..95	CDD:275380	3/22 (14%)
		leucine-rich repeat	96..121	CDD:275380	7/24 (29%)
		LRR_8	121..177	CDD:290566	20/86 (23%)
		leucine-rich repeat	122..142	CDD:275380	9/20 (45%)
		leucine-rich repeat	143..166	CDD:275380	6/52 (12%)
		LRR_8	166..247	CDD:290566	28/106 (26%)
		leucine-rich repeat	167..191	CDD:275380	8/46 (17%)
		leucine-rich repeat	192..212	CDD:275380	8/22 (36%)
		leucine-rich repeat	213..236	CDD:275380	6/22 (27%)
		LRR_8	235..292	CDD:290566	23/60 (38%)
		leucine-rich repeat	237..261	CDD:275380	8/23 (35%)
		leucine-rich repeat	282..311	CDD:275380	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100