DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and Toll-6

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	141/562 - (25%)
Similarity:	240/562 - (42%)	Gaps:	104/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLLPGSLLLLIFSFSPRLSCLQLSK-------------------CNNTEVTLIRKTELLTSLTL 46
            ::.||.:    ||.....||.|.:|:                   ..:||.|...::...:|.:.
  Fly   212 IWSLPDN----IFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSS 272

  Fly    47 SNCTL-------PHVE------NGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNN 98
            ::|:|       .|.:      |||.. ...|..|.:.::|:|.:.|.:|:||..||.|:||.|.
  Fly   273 TSCSLDLEYLDVSHNDFVVLPANGFGT-LRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK 336

  Fly    99 LSSL-RSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQ--IENDSFDGLSH 160
            :.:| ....:|....:..:.|.:|.:|.|:.:.|....|||.|||..|:|:.  |:.::|.||..
  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIR 401

  Fly   161 LKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFL 225
            |..|.|:.|:|..::...|..|:.|..|:|:||::|.|..|:|....:|.:|.|..|.|..|...
  Fly   402 LVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAY 466

  Fly   226 SQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDL-----------------------DLSYNNI 267
            :..||..|..|:|.:|.|..:.|..|.....||||                       ||..|.|
  Fly   467 ALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMI 531

  Fly   268 TKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEI 332
            |.:...|..||.:|..|.:..||::.|...:...|..|..|:::.|.:..:....|...:.::.:
  Fly   532 TVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAV 596

  Fly   333 ILANNKIEEISSQMMFNQNHLRYIKLSGNAI---------SDAAFLD----RLSPSVNRFTL--- 381
            .|..|::.:|:. :..|...|.::.:|.|.:         |...:||    |||...|||.|
  Fly   597 RLDGNELNDING-LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSE 660

  Fly   382 ----YVDLSSNRLKSLNLSSLLHFRYINLADNNWSCNWLVANLVQKLP-----NSVNFARPWTVI 437
                .:|:|.|:|:.:..||:         .|:....:|..||:..:.     :..|..|.....
  Fly   661 LKLQTLDVSFNQLQRIGPSSI---------PNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYA 716

  Fly   438 NNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDC 479
            |.::  |.:::.:..:....:|::....:.|.|    ..|||
  Fly   717 NQIT--TLDIKSLRILPVWEHRALPEFYIGGNP----FTCDC 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/35 (20%)
		LRR_8	64..123	CDD:290566	18/59 (31%)
		leucine-rich repeat	65..88	CDD:275380	8/22 (36%)
		leucine-rich repeat	89..112	CDD:275380	8/23 (35%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	115..384	CDD:238064	87/313 (28%)
		LRR_8	135..195	CDD:290566	24/61 (39%)
		leucine-rich repeat	137..160	CDD:275380	11/24 (46%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	21/58 (36%)
		leucine-rich repeat	185..208	CDD:275380	9/22 (41%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..289	CDD:290566	21/79 (27%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..280	CDD:275380	12/45 (27%)
		LRR_8	280..339	CDD:290566	12/58 (21%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	4/22 (18%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	8/27 (30%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	13/69 (19%)
		leucine-rich repeat	229..249	CDD:275380	2/19 (11%)
		LRR_RI	278..468	CDD:238064	59/190 (31%)
		leucine-rich repeat	279..302	CDD:275380	4/23 (17%)
		LRR_8	301..386	CDD:290566	28/84 (33%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	101/390 (26%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..401	CDD:275380	11/24 (46%)
		LRR_RI	<401..626	CDD:238064	60/225 (27%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	4/19 (21%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	4/22 (18%)
		leucine-rich repeat	593..615	CDD:275380	4/22 (18%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	9/23 (39%)
		leucine-rich repeat	663..684	CDD:275380	6/29 (21%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	3/20 (15%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910