DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Flrt1

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_958813.1	Gene:	Flrt1 / 396184	MGIID:	3026647	Length:	674	Species:	Mus musculus

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	199/554 - (35%)	Gaps:	186/554 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LLTSLT--LSNCTLPHV---ENGFFVRFD-----------------HLLHLELQHSGLSDLDDFS 82
            |:..||  :.:.|.|.|   :|||....|                 :|.:.::.::|:..    .
Mouse    41 LIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQ----D 101

  Fly    83 LNGLTKLQYLSLSHNNLSSLRSWSSEPLG---ALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRY 144
            |....|:|.:.|..|:|...      |:.   :|..|.|..|.:..::..|..:.|.|::|.|..
Mouse   102 LKTKVKVQVIYLYENDLDEF------PINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDD 160

  Fly   145 NRIS--QIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGL-HRLSSLSLQHNRIEFIEMDSFESN 206
            |.:|  .||.|:|.....||.|:|:.|.|:.|..    || |.|..|.|..|||..|.:.:|:..
Mouse   161 NSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPS----GLPHTLEELRLDDNRISTIPLHAFKGL 221

  Fly   207 THLRSLRLDQNLL----------SSLQFLSQRGLAR----LVHLNLSSNLLQKLEPFVFSKNFEL 257
            ..||.|.||.|||          |.||.|::..|.|    ...|||.|..||||         .|
Mouse   222 NSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKL---------YL 277

  Fly   258 QDLDLS---YNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLP 319
            ||..:|   ||.:.|:.:        |||                        ||:|.|.|||||
Mouse   278 QDNAISHIPYNTLAKMRE--------LER------------------------LDLSNNNLTTLP 310

  Fly   320 DNLFHFNTQLEEIILANN--------------------------------------KIEEISSQM 346
            ..||.....|.:::|.||                                      .|::|:|:|
Mouse   311 RGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEM 375

  Fly   347 --MFNQNHLRYIKLSGNAISDAA------FLDRLSPSVNRFTLYVDLSSNRLKSLNL-------- 395
              .|....      .|.|.:.||      .....:|..:.|||.......||...|:
Mouse   376 DECFEAGS------QGGAANAAAKTTVSNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGD 434

  Fly   396 -SSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPW------TVINNLSENTTNVEGIDCI 453
             :..|..:...|..::....|..     .||.| :|...|      ..:.:::|  |.|:|
Mouse   435 GAKTLVIQVKPLTADSIRITWKA-----MLPAS-SFRLSWLRLGHSPAVGSITE--TLVQG---- 487

  Fly   454 EGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETN 487
                :::..||...   :|||....|:|..:..|
Mouse   488 ----DKTEYLLTAL---EPKSTYIICMVTMETGN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	9/44 (20%)
		LRR_8	64..123	CDD:290566	13/61 (21%)
		leucine-rich repeat	65..88	CDD:275380	3/22 (14%)
		leucine-rich repeat	89..112	CDD:275380	5/25 (20%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	115..384	CDD:238064	92/334 (28%)
		LRR_8	135..195	CDD:290566	24/62 (39%)
		leucine-rich repeat	137..160	CDD:275380	9/24 (38%)
		leucine-rich repeat	161..184	CDD:275380	9/23 (39%)
		LRR_8	184..243	CDD:290566	26/72 (36%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..232	CDD:275380	13/32 (41%)
		LRR_8	232..289	CDD:290566	19/63 (30%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	7/25 (28%)
		LRR_8	280..339	CDD:290566	18/96 (19%)
		leucine-rich repeat	281..304	CDD:275380	3/22 (14%)
		leucine-rich repeat	305..328	CDD:275380	11/22 (50%)
Flrt1	NP_958813.1	PRK15370	<58..>329	CDD:185268	92/325 (28%)
		leucine-rich repeat	108..128	CDD:275380	5/25 (20%)
		leucine-rich repeat	129..152	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..178	CDD:275380	9/24 (38%)
		leucine-rich repeat	179..199	CDD:275380	9/23 (39%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..249	CDD:275380	10/24 (42%)
		leucine-rich repeat	250..271	CDD:275380	7/20 (35%)
		leucine-rich repeat	272..295	CDD:275380	11/31 (35%)
		leucine-rich repeat	296..319	CDD:275380	14/46 (30%)
		PCC	300..>406	CDD:188093	23/111 (21%)
		FN3	441..505	CDD:214495	16/82 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100