DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and Flrt3

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001119763.1	Gene:	Flrt3 / 366205	RGDID:	1566005	Length:	649	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	127/575 - (22%)
Similarity:	209/575 - (36%)	Gaps:	193/575 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPGSLLLLIFSFSP----RLSCLQLSKCNNTEVTLIRKTELLTSLTL---SNCTLPHVENGFFVR 61
            |.|:.:.|.|..:|    ..||..:.:|:...:....::  |||:.:   .:.|..:::|.
  Rat    10 LIGTKIGLFFQVAPLSVMAKSCPSVCRCDAGFIYCNDRS--LTSIPVGIPEDATTLYLQNN---- 68

  Fly    62 FDHLLHLELQHSGL-SDLDDFSLNGLTKLQYLSLSHNNL----SSLRSWSSEPLGALTNLDLSHN 121
                   ::.:.|: ||     |..|.|:|.:.|.||:|    ::|..:..|       |.|..|
  Rat    69 -------QINNVGIPSD-----LKNLLKVQRIYLYHNSLDEFPTNLPKYVKE-------LHLQEN 114

  Fly   122 MLSKLSVKSFEQYPQLQQLDLRYNRIS--QIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHR 184
            .:..::..|..:.|.|::|.|..|.:|  .||..:|...::|:.|:|:.|.|:.|.|    ||.|
  Rat   115 NIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPG----GLPR 175

  Fly   185 -LSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEP 248
             :..|.|..|||..|...|....|.|:.|.||.|||::      .||...|..||
  Rat   176 TIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNN------HGLGDKVFFNL---------- 224

  Fly   249 FVFSKNFELQDLDLSYNNIT--KLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDIS 311
                  ..|.:|.|..|::|  .:|   |.| .||.:|.:..|:::::...:...|..|.:||:|
  Rat   225 ------VNLTELSLVRNSLTAAPVN---LPG-TSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMS 279

  Fly   312 FNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSV 376
            .|.|:.||..:|.....:.::||.||.
  Rat   280 NNNLSNLPQGIFDDLDNITQLILRNNP-------------------------------------- 306

  Fly   377 NRFTLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSC----NWLVANLVQKLPNSVN----FARP 433
                                              |.|    .| |.:.:|.||..||    ..:.
  Rat   307 ----------------------------------WYCGCKMKW-VRDWLQSLPVKVNVRGLMCQA 336

  Fly   434 WTVINNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPLTW--- 495
            ...:..::....:.|..||.:.|...::.:  .:.:|.         .||......|.|:|.
  Rat   337 PEKVRGMAIKDLSAELFDCKDSGIVSTVQI--TTAIPN---------TAYPAQGQWPAPVTKQPD 390

  Fly   496 ---PKIPTDR----FDSRSVII--------------WMLVAIAIAFSGLR--WLR 527
               ||:..|:    ..||..|:              |.|   |:..:.||  ||:
  Rat   391 IKNPKLTKDQRTTGSPSRKTILITVKSVTPDTIHISWRL---ALPMTALRLSWLK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/25 (20%)
		LRR_8	64..123	CDD:290566	16/63 (25%)
		leucine-rich repeat	65..88	CDD:275380	5/23 (22%)
		leucine-rich repeat	89..112	CDD:275380	7/26 (27%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		LRR_RI	115..384	CDD:238064	69/273 (25%)
		LRR_8	135..195	CDD:290566	22/62 (35%)
		leucine-rich repeat	137..160	CDD:275380	8/24 (33%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		LRR_8	184..243	CDD:290566	21/59 (36%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	14/58 (24%)
		leucine-rich repeat	233..256	CDD:275380	3/22 (14%)
		leucine-rich repeat	257..280	CDD:275380	8/24 (33%)
		LRR_8	280..339	CDD:290566	18/58 (31%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
Flrt3	NP_001119763.1	LRRNT	31..61	CDD:214470	5/31 (16%)
		Interaction with ADGRL3. /evidence=ECO:0000250\|UniProtKB:Q9NZU0	38..67		4/30 (13%)
		LRR 1. /evidence=ECO:0000255	59..80		5/36 (14%)
		LRR_4	61..100	CDD:289563	13/54 (24%)
		leucine-rich repeat	61..84	CDD:275378	7/38 (18%)
		LRR 2. /evidence=ECO:0000255	84..104		7/19 (37%)
		leucine-rich repeat	85..104	CDD:275380	6/18 (33%)
		LRR 3. /evidence=ECO:0000255	105..126		5/27 (19%)
		LRR_8	106..166	CDD:290566	18/66 (27%)
		leucine-rich repeat	106..129	CDD:275380	5/29 (17%)
		LRR_RI	109..327	CDD:238064	76/320 (24%)
		LRR 4. /evidence=ECO:0000255	129..150		7/20 (35%)
		leucine-rich repeat	130..155	CDD:275380	8/24 (33%)
		LRR 5. /evidence=ECO:0000255	155..176		9/24 (38%)
		leucine-rich repeat	156..176	CDD:275380	9/23 (39%)
		LRR_8	175..237	CDD:290566	25/83 (30%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR 6. /evidence=ECO:0000255	177..197		7/19 (37%)
		LRR 7. /evidence=ECO:0000255	200..220		9/25 (36%)
		leucine-rich repeat	201..226	CDD:275380	12/46 (26%)
		LRR 8. /evidence=ECO:0000255	226..247		8/24 (33%)
		leucine-rich repeat	227..248	CDD:275380	8/24 (33%)
		LRR_8	247..306	CDD:290566	17/58 (29%)
		LRR 9. /evidence=ECO:0000255	248..269		4/20 (20%)
		leucine-rich repeat	249..272	CDD:275380	4/22 (18%)
		LRR 10. /evidence=ECO:0000255	272..293		9/20 (45%)
		leucine-rich repeat	273..296	CDD:275380	9/22 (41%)
		LRRCT	305..356	CDD:214507	12/123 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..405		6/26 (23%)
		fn3	413..478	CDD:278470	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100