DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and LRRTM1

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	479	Identity:	117/479 - (24%)
Similarity:	192/479 - (40%)	Gaps:	84/479 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 ALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDG 176
            ||...:..||:...|.            |.||||.:|::....|.||..|..|||:.|.:..:.|
Human    54 ALNLTEAPHNLSGLLG------------LSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQG 106

  Fly   177 SFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSN 241
            ..|:.|.|:..|:|..|:|..:...:|....:|||:.|..|.|.:|......||.:|..|::.:|
Human   107 DAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRAN 171

  Fly   242 LLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALL 306
            .:|.:...:|.....|:.||:.||.:..|.:.:.:||..|..|::.||.:.|:.......||:|.
Human   172 AIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLH 236

  Fly   307 QLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDR 371
            .|.:..|.:..:..:| .:...||::.|:.|:||.:...:.....||:.::|..|.      |..
Human   237 SLCLRRNKVAIVVSSL-DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNR------LTY 294

  Fly   372 LSPSVNRFTLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSCNWLVANLVQKLPN---------- 426
            :.|.:          .|..|||.        .|.||.|.|.|...|..|...|.|
Human   295 IEPRI----------LNSWKSLT--------SITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQ 341

  Fly   427 --SVNFARPWTVIN-----NLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDN-CDCVVAY 483
              |..:|:...|::     :|.|:.........:...||||.:     |.|...:.. .|.....
Human   342 CASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDL-----GPPASSATTLADGGEGQ 401

  Fly   484 DETNPSPPPLTWP------------KIPTDRFDSRSVIIWMLVAIAIAF-------SGLRWLRR- 528
            .:....|..:..|            |:.|   .:.::|...|:.:.:.:       :.||.||:
Human   402 HDGTFEPATVALPGGEHAENAVQIHKVVT---GTMALIFSFLIVVLVLYVSWKCFPASLRQLRQC 463

  Fly   529 FVDRNEKRKLGQKMLHNVYVSKVQ 552
            ||.:..|:|..|.| |.:.....|
Human   464 FVTQRRKQKQKQTM-HQMAAMSAQ 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566	4/10 (40%)
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380	117/479 (24%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		LRR_RI	115..384	CDD:238064	71/268 (26%)
		LRR_8	135..195	CDD:290566	21/59 (36%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	18/58 (31%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	15/56 (27%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		LRR_8	280..339	CDD:290566	15/58 (26%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	4/22 (18%)
LRRTM1	NP_849161.2	LRR 1	64..87		8/34 (24%)
		LRR_8	73..125	CDD:290566	19/51 (37%)
		LRR_RI	<85..268	CDD:238064	54/183 (30%)
		LRR 2	89..111		7/21 (33%)
		leucine-rich repeat	91..114	CDD:275380	8/22 (36%)
		LRR 3	112..135		7/22 (32%)
		LRR_8	113..173	CDD:290566	18/59 (31%)
		leucine-rich repeat	115..138	CDD:275380	5/22 (23%)
		LRR 4	137..159		7/21 (33%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		LRR_8	161..221	CDD:290566	17/59 (29%)
		LRR 5	161..183		5/21 (24%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		LRR 6	184..207		6/22 (27%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		LRR 7	209..231		5/21 (24%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		LRR 8	233..255		5/22 (23%)
		leucine-rich repeat	235..257	CDD:275380	4/22 (18%)
		LRR 9	256..278		6/21 (29%)
		LRR_8	257..315	CDD:290566	19/81 (23%)
		LRR_4	257..297	CDD:289563	11/45 (24%)
		leucine-rich repeat	258..281	CDD:275380	6/22 (27%)
		LRR 10	279..302		6/38 (16%)
		leucine-rich repeat	282..300	CDD:275380	5/33 (15%)
		leucine-rich repeat	306..318	CDD:275378	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401		4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910