DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Nepn

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006256553.1	Gene:	Nepn / 309775	RGDID:	1307755	Length:	512	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	114/414 - (27%)
Similarity:	187/414 - (45%)	Gaps:	33/414 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPGSLLLLIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHL 68
            :|.:...|..|.| |:..||||  |.|::..:....||.|.|.|      :||..|.....|..|
  Rat    45 IPSTTRRLYISHS-RIQHLQLS--NLTQLLALEDFILLASGTES------IENDTFKTLTTLKTL 100

  Fly    69 ELQHSGLSDLDDFSLNGL-TKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFE 132
            ||..:.|..:.    :.| ..|:.|.|:.|::.:|.....|.|..|..|:|.:|::|.||.....
  Rat   101 ELWKNKLRRVP----SALPANLEVLKLNDNSICALHGSDFEGLSNLKVLELKNNLISSLSPSMLS 161

  Fly   133 QYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEF 197
            ....||.|.:..|.|..:....  .|.:||::.:..|:|..|.|:.|..|..|..||...|.:..
  Rat   162 SLVSLQSLLVDGNNIESVTGPL--SLPNLKYMSMEKNKLHLISGNVFTSLQNLQFLSFSGNFLTK 224

  Fly   198 IEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDL 262
            |.::..:|   |.||::::|.|..::|...|.|..|.||.||.|||..::......|  |..|:.
  Rat   225 IPINLPKS---LLSLKMERNQLKVVRFRDMRHLENLSHLYLSENLLSSIDGAQLLTN--LTTLEA 284

  Fly   263 SYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNT 327
            |.|.:..|.....|   .|::|:.|.|::.::.......|..|..|.:..|:::..........:
  Rat   285 SQNRLQMLPPRLPS---RLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQKCS 346

  Fly   328 QLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKS 392
            ||..:.|..|.:..|..::   ...|..:.|.||||.|.|  :|....:.:..: ::|.:|::.:
  Rat   347 QLSNLALEQNLLLSIPLRL---PKTLARLDLKGNAIQDMA--ERELRDLKQLQV-LNLRNNKISA 405

  Fly   393 LNLSS---LLHFRYINLADNNWSC 413
            |:|.:   |...|::.|..|.|:|
  Rat   406 LDLKALEGLPRLRHLYLDGNPWNC 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/22 (32%)
		LRR_8	64..123	CDD:290566	17/59 (29%)
		leucine-rich repeat	65..88	CDD:275380	6/23 (26%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	71/268 (26%)
		LRR_8	135..195	CDD:290566	18/59 (31%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	20/58 (34%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..289	CDD:290566	18/56 (32%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		LRR_8	280..339	CDD:290566	12/58 (21%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
Nepn	XP_006256553.1	leucine-rich repeat	50..72	CDD:275380	10/24 (42%)
		leucine-rich repeat	73..96	CDD:275380	8/28 (29%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		leucine-rich repeat	142..165	CDD:275380	7/22 (32%)
		leucine-rich repeat	166..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	7/25 (28%)
		leucine-rich repeat	236..256	CDD:275380	6/19 (32%)
		LRR_RI	<251..425	CDD:238064	46/184 (25%)
		leucine-rich repeat	257..278	CDD:275380	8/20 (40%)
		leucine-rich repeat	279..299	CDD:275380	6/22 (27%)
		LRR_8	298..358	CDD:290566	13/62 (21%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	324..347	CDD:275380	3/22 (14%)
		leucine-rich repeat	348..371	CDD:275380	5/25 (20%)
		LRR_8	367..426	CDD:290566	16/61 (26%)
		leucine-rich repeat	372..392	CDD:275380	8/21 (38%)
		leucine-rich repeat	393..416	CDD:275380	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100