DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Flrt2

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001100220.1	Gene:	Flrt2 / 299236	RGDID:	1308574	Length:	660	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	97/448 - (21%)
Similarity:	180/448 - (40%)	Gaps:	105/448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LYLNGNQLAHIDGSFFRGLHRLSSLS---LQHNRIEFIEMDSFESN--THLRSLRLDQNLLSSLQ 223
            |||:.||:.  :..|...||.:.|:.   |..|     ::|.|..|  .::|.|.|.:|   ::|
  Rat    68 LYLHNNQIN--NAGFPAELHNVQSVHTVYLYGN-----QLDEFPMNLPKNVRVLHLQEN---NIQ 122

  Fly   224 FLSQRGLARLV---HLNLSSNLLQK--LEPFVFSKNFELQDLDLSYNNITKLNKEALSGLD-SLE 282
            .:|:..||:|:   .|:|..|.:..  :|...|.:...|:.|.||.|:::.:.    .||. .|:
  Rat   123 TISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQ 183

  Fly   283 RLNISHNYVDKIYDESLDSLIALLQLDISFNLLTT--LPDNLFHFNTQLEEIILANNKIEEISS- 344
            .|.:..|.:..|.|.:..:|.:|.:|.:..||||.  :.|..|...|:|:|..:..|.:.....
  Rat   184 ELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIADGTFSHLTKLKEFSIVRNSLSHPPPD 248

  Fly   345 -------QMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLN---LSSLL 399
                   ::....|.:.:|.|:  |.::...|:||           |:|:|:|:.|.   ...|.
  Rat   249 LPGTHLIRLYLQDNQINHIPLT--AFANLRKLERL-----------DISNNQLRMLTQGVFDHLS 300

  Fly   400 HFRYINLADNNWSCN----WLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEGGTNRS 460
            :.:.:...:|.|.|:    | |...::.:|:|:|      |...:.:....|.|:...|...|..
  Rat   301 NLKQLTARNNPWFCDCSIKW-VTEWLKYIPSSLN------VRGFMCQGPEQVRGMAVRELNMNLL 358

  Fly   461 IILLDVSGVP---------QPKSDNCDCVV---AYDETNPSPPPLTWPKIP------------TD 501
            .......|:|         .|.:.:....|   :.....|:|.|...|.||            ::
  Rat   359 SCPTTTPGLPVFTPAPSTVSPTTQSPTVSVPSPSRGSVPPAPAPSKLPTIPDWDGRERATPPISE 423

  Fly   502 RF--------DSRSVIIWMLVAIAIAFSGLRWLRRFVDRNEKRKLGQKMLHNVYVSKV 551
            |.        |:...:.|:.:...:|:. |.|:          |:|..::..:...::
  Rat   424 RIQLSIHFVNDTSIQVSWLSLFTVMAYK-LTWV----------KMGHSLVGGIVQERI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_RI	115..384	CDD:238064	60/240 (25%)
		LRR_8	135..195	CDD:290566	11/33 (33%)
		leucine-rich repeat	137..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380	7/19 (37%)
		LRR_8	184..243	CDD:290566	18/66 (27%)
		leucine-rich repeat	185..208	CDD:275380	6/27 (22%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	15/62 (24%)
		leucine-rich repeat	233..256	CDD:275380	6/27 (22%)
		leucine-rich repeat	257..280	CDD:275380	7/23 (30%)
		LRR_8	280..339	CDD:290566	18/60 (30%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	8/24 (33%)
Flrt2	NP_001100220.1	LRRNT	35..66	CDD:214470
		LRR 1. /evidence=ECO:0000255	62..87		8/20 (40%)
		leucine-rich repeat	65..86	CDD:275378	7/19 (37%)
		LRR 2. /evidence=ECO:0000255	88..108		6/24 (25%)
		PPP1R42	89..311	CDD:411060	58/246 (24%)
		leucine-rich repeat	90..110	CDD:275380	5/24 (21%)
		LRR 3. /evidence=ECO:0000255	109..131		7/24 (29%)
		leucine-rich repeat	111..134	CDD:275380	9/25 (36%)
		LRR 4. /evidence=ECO:0000255	132..157		6/24 (25%)
		leucine-rich repeat	135..160	CDD:275380	5/24 (21%)
		LRR 5. /evidence=ECO:0000255	159..181		7/25 (28%)
		leucine-rich repeat	161..181	CDD:275380	7/23 (30%)
		leucine-rich repeat	182..205	CDD:275380	6/22 (27%)
		LRR 6. /evidence=ECO:0000255	183..202		4/18 (22%)
		LRR 7. /evidence=ECO:0000255	203..228		9/24 (38%)
		leucine-rich repeat	206..231	CDD:275380	8/24 (33%)
		LRR 8. /evidence=ECO:0000255	229..251		4/21 (19%)
		leucine-rich repeat	232..253	CDD:275380	3/20 (15%)
		LRR 9. /evidence=ECO:0000255	252..274		4/23 (17%)
		leucine-rich repeat	254..277	CDD:275380	4/24 (17%)
		LRR 10. /evidence=ECO:0000255	275..298		8/33 (24%)
		leucine-rich repeat	278..301	CDD:275380	9/33 (27%)
		PCC	282..>359	CDD:188093	19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..413		8/40 (20%)
		fn3	426..494	CDD:394996	7/56 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100