DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Podnl1

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_213845.6	Gene:	Podnl1 / 288907	RGDID:	1307753	Length:	582	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	121/438 - (27%)
Similarity:	193/438 - (44%)	Gaps:	79/438 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIFSFSPRLSCLQL--SKCNNTEV--TLIRKTELLTSLTLSN-------CTLP------HVENGF 58
            |.|...|.|..:.|  ::..||.:  .....:|.:|:|:||:       .:||      |::|..
  Rat   170 LTFGEKPALRSVYLHNNRLRNTGLPPNTFHGSEAITTLSLSSNQLRYLPPSLPASLERLHLQNNL 234

  Fly    59 FVRF--------DHLLHLELQHSGLSD--LDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPL-GA 112
            ..:.        ..|..|.|||:.|:|  ||..:.:.|:.|:||.||||.|:::    .|.| |.
  Rat   235 ISKVPRGALSLQTQLRELYLQHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATV----PEGLPGN 295

  Fly   113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRI--SQIENDSFDGLSHLKHLYLNGNQLAHID 175
            ||.|.|..|.:..:......:...|:.|.|::|::  |.:...:...|..|..|:|.||:|..:.
  Rat   296 LTILHLGRNCIRHVEAIRLHKAKGLRYLLLQHNKLEASALPAGTLRPLRALHTLHLYGNRLERVP 360

  Fly   176 GSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFL--SQRGLARLVHLNL 238
            .:..|   .|.:|.:.|||:..:......|...|..|.|..|.|:|....  :.|.|..|..|:|
  Rat   361 PALPR---HLQALVMPHNRVAALGARDLVSARALTELNLAYNRLASAHVHPGAFRRLRALRSLDL 422

  Fly   239 SSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHN--YVDKIYDESLDS 301
            :.|.|.:|...:.:   .|:.|.|..|.:..|..|.|:||:.|..||::||  .|..|...:...
  Rat   423 AGNQLSRLPEGLPA---SLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRVGDIEPGAWHE 484

  Fly   302 LIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDA 366
            |.||..||:|.|.|:.:|.:|   ...|||:.|..|:|..:..:...:..|||       |:|
  Rat   485 LQALQVLDLSHNELSFVPPDL---PEALEELYLQANRISHVGPEAFLSTPHLR-------ALS-- 537

  Fly   367 AFLDRLSPSVNRFTLYVDLSSNRLKSLNLSS-----LLHFRYINLADN 409
                              |.:|||...::::     |.|.|.::.|:|
  Rat   538 ------------------LRANRLHMTSIAAEAFRGLAHLRVVDTAEN 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	8/43 (19%)
		LRR_8	64..123	CDD:290566	26/61 (43%)
		leucine-rich repeat	65..88	CDD:275380	10/24 (42%)
		leucine-rich repeat	89..112	CDD:275380	10/23 (43%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	115..384	CDD:238064	73/274 (27%)
		LRR_8	135..195	CDD:290566	17/61 (28%)
		leucine-rich repeat	137..160	CDD:275380	6/24 (25%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	18/60 (30%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	8/24 (33%)
		LRR_8	232..289	CDD:290566	18/56 (32%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	9/22 (41%)
		LRR_8	280..339	CDD:290566	22/60 (37%)
		leucine-rich repeat	281..304	CDD:275380	8/24 (33%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
Podnl1	XP_213845.6	leucine-rich repeat	64..82	CDD:275380
		leucine-rich repeat	83..106	CDD:275380
		LRR_8	84..143	CDD:290566
		leucine-rich repeat	107..132	CDD:275380
		leucine-rich repeat	133..177	CDD:275380	2/6 (33%)
		LRR_8	152..214	CDD:290566	12/43 (28%)
		LRR_RI	175..451	CDD:238064	77/285 (27%)
		leucine-rich repeat	178..203	CDD:275380	4/24 (17%)
		leucine-rich repeat	204..224	CDD:275380	6/19 (32%)
		LRR_8	224..285	CDD:290566	19/60 (32%)
		leucine-rich repeat	225..248	CDD:275380	2/22 (9%)
		leucine-rich repeat	249..274	CDD:275380	10/24 (42%)
		leucine-rich repeat	275..319	CDD:275380	16/47 (34%)
		LRR_8	295..356	CDD:290566	16/60 (27%)
		leucine-rich repeat	298..317	CDD:275380	3/18 (17%)
		leucine-rich repeat	320..345	CDD:275380	6/24 (25%)
		leucine-rich repeat	346..390	CDD:275380	13/46 (28%)
		LRR_8	365..427	CDD:290566	19/64 (30%)
		leucine-rich repeat	391..416	CDD:275380	8/24 (33%)
		leucine-rich repeat	417..440	CDD:275380	7/25 (28%)
		LRR_8	437..498	CDD:290566	23/60 (38%)
		leucine-rich repeat	441..461	CDD:275380	8/19 (42%)
		leucine-rich repeat	462..487	CDD:275380	8/24 (33%)
		LRR_8	488..543	CDD:290566	21/84 (25%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		leucine-rich repeat	533..556	CDD:275380	8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100