DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and Lgi1

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_665712.1	Gene:	Lgi1 / 252892	RGDID:	628742	Length:	557	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	81/421 - (19%)
Similarity:	150/421 - (35%)	Gaps:	145/421 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 NLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFF 179
            :|....:..:::|..||...|.||.|....|....|.:|:|.||.||::|::..|.:..|....|
  Rat    71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTF 135

  Fly   180 RGLHRLSSLSLQHNRIEFIEMDSFE-----SNTHLR--SLRLDQNLLSSLQFLSQRGLARLVHLN 237
            |||..|..|||.:|.::.:..|.|:     :|..||  |...|..|...:::|.        |.|
  Rat   136 RGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLG--------HTN 192

  Fly   238 LS-------------SNLLQKLEPFVFSKNFE------LQDLDLSYNNITKLNKEALSGLDSLER 283
            .:             ...:..|.|    |:|:      .:..||.|.:::         :|:...
  Rat   193 ATVEDIYCEGPPEYKKRKINSLSP----KDFDCIITEFAKSQDLPYQSLS---------IDTFSY 244

  Fly   284 LN----------------ISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEI 332
            ||                :..::|:|.:...                     ||:...:|.:.:.
  Rat   245 LNDEYVVIAQPFTGKCIFLEWDHVEKTFRNY---------------------DNITGTSTVVCKP 288

  Fly   333 ILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLNLSS 397
            |:.:.::..|.:| :|..:|:  .|..|.|              |:|....|:...:::..|  .
  Rat   289 IVIDTQLYVIVAQ-LFGGSHI--YKRDGFA--------------NKFIKIQDIEVLKIRKPN--D 334

  Fly   398 LLHFR-----YINLADNN---------WSCNWLVAN---------------------LVQKLPN- 426
            :..|:     |..:||::         |:.|...::                     |..:.|:
  Rat   335 IETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLTLRTPHL 399

  Fly   427 --SVNFARP----WTVINNLSENTTNVEGID 451
              |.:..||    |:....|..|.|::..::
  Rat   400 ILSSSSQRPVIYQWSKATQLFINQTDIPNME 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566	1/7 (14%)
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380	4/20 (20%)
		LRR_RI	115..384	CDD:238064	64/310 (21%)
		LRR_8	135..195	CDD:290566	24/59 (41%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	16/78 (21%)
		leucine-rich repeat	185..208	CDD:275380	8/27 (30%)
		leucine-rich repeat	209..232	CDD:275380	6/24 (25%)
		LRR_8	232..289	CDD:290566	12/91 (13%)
		leucine-rich repeat	233..256	CDD:275380	5/35 (14%)
		leucine-rich repeat	257..280	CDD:275380	3/22 (14%)
		LRR_8	280..339	CDD:290566	8/74 (11%)
		leucine-rich repeat	281..304	CDD:275380	4/38 (11%)
		leucine-rich repeat	305..328	CDD:275380	2/22 (9%)
Lgi1	NP_665712.1	leucine-rich repeat	71..92	CDD:275378	4/20 (20%)
		LRR_8	91..151	CDD:404697	24/59 (41%)
		LRR 1	92..113		7/20 (35%)
		leucine-rich repeat	93..116	CDD:275378	9/22 (41%)
		LRR 2	116..137		6/20 (30%)
		leucine-rich repeat	117..140	CDD:275378	8/22 (36%)
		LRR 3	140..161		7/20 (35%)
		leucine-rich repeat	141..164	CDD:275378	7/22 (32%)
		PCC	146..>221	CDD:188093	17/86 (20%)
		leucine-rich repeat	165..177	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267		6/50 (12%)
		EPTP	225..264	CDD:397689	6/47 (13%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313		9/65 (14%)
		EPTP	272..310	CDD:397689	8/61 (13%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364		8/48 (17%)
		EPTP	317..361	CDD:397689	7/45 (16%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415		6/48 (13%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462		3/12 (25%)
		EPTP	420..459	CDD:397689	2/11 (18%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506
		EPTP	464..502	CDD:397689
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..549	CDD:397689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930