DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and Podn

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001272885.1	Gene:	Podn / 242608	MGIID:	2674939	Length:	611	Species:	Mus musculus

Alignment Length:	518	Identity:	120/518 - (23%)
Similarity:	214/518 - (41%)	Gaps:	130/518 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSD--LDDFSLNGLTKLQYLSLSHNNLSSLRSWS 106
            |:|.|..|..:......|...|..|.||::.|:.  |.:.:...||.|.||.|::|.|:....:.
Mouse   102 LSLQNNQLEKIYPEELSRLQRLETLNLQNNRLTSRGLPEEAFEHLTSLNYLYLANNKLTLAPRFL 166

  Fly   107 SEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQ--IENDSFDGLSHLKHLYLNGN 169
            .   .||.::|.:.|.|:|:...:|.|.|.|:.:.|..|:::.  :.:..|:|.|:::.|.|:.|
Mouse   167 P---NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDHMFNGSSNVEILILSSN 228

  Fly   170 QLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNL-------------LSS 221
            .|.|:.......|::   |.|::|::|.|...:|...::||.|.|..|.             |||
Mouse   229 FLRHVPKHLPPALYK---LHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTDEGLDNETFWKLSS 290

  Fly   222 LQF--LSQRGLAR--------LVHLNLSSNLLQKLEPFVFS--KNFE------------------ 256
            |::  ||...|:|        ||.|:|..|.:|.:|..|.:  :|.|
Mouse   291 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIQSVEADVLTPIRNLEYLLLHSNQLQAKGIHPLA 355

  Fly   257 ---------------------------LQDLDLSYNNITKLNKEALSGLDSLERLNISHNYV--D 292
                                       ::.|.:.:|.||.:.:|..:....||.||:|:|.:  .
Mouse   356 FQGLKKLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 420

  Fly   293 KIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIK 357
            :::.::...|..|..||:|.|.|.|||..|   ...:..:.:..|::..::...:.....||.:.
Mouse   421 QMHRDAFRKLRLLRSLDLSGNRLQTLPPGL---PKNVHVLKVKRNELAALARGALAGMAQLRELY 482

  Fly   358 LSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLNLSSLLHFRYINLADNNWSCNWLVANLVQ 422
            |:||.:...|    |.|..     :|||:..:|             :::|.|.      :..:.:
Mouse   483 LTGNRLRSRA----LGPRA-----WVDLAGLQL-------------LDIAGNQ------LTEVPE 519

  Fly   423 KLPNSVNFA-----RPWTVINNLSENTTNVEGI----------DCIEGGTNR--SIILLDVSG 468
            .||.|:.:.     :...|..|..::|.|::||          ..:|....|  .:.:||:.|
Mouse   520 GLPPSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVESAFRRLKHLQVLDIEG 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/19 (26%)
		LRR_8	64..123	CDD:290566	18/60 (30%)
		leucine-rich repeat	65..88	CDD:275380	7/24 (29%)
		leucine-rich repeat	89..112	CDD:275380	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	79/342 (23%)
		LRR_8	135..195	CDD:290566	16/61 (26%)
		leucine-rich repeat	137..160	CDD:275380	5/24 (21%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		LRR_8	184..243	CDD:290566	24/81 (30%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	12/37 (32%)
		LRR_8	232..289	CDD:290566	21/111 (19%)
		leucine-rich repeat	233..256	CDD:275380	9/24 (38%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		LRR_8	280..339	CDD:290566	18/60 (30%)
		leucine-rich repeat	281..304	CDD:275380	7/24 (29%)
		leucine-rich repeat	305..328	CDD:275380	10/22 (45%)
Podn	NP_001272885.1	PRK15370	<71..>309	CDD:185268	59/212 (28%)
		leucine-rich repeat	80..97	CDD:275380
		LRR 1	98..119		4/16 (25%)
		leucine-rich repeat	101..122	CDD:275380	5/19 (26%)
		PLN00113	119..>583	CDD:215061	116/501 (23%)
		LRR 2	122..145		6/22 (27%)
		leucine-rich repeat	123..148	CDD:275380	7/24 (29%)
		LRR 3	148..169		6/23 (26%)
		leucine-rich repeat	149..193	CDD:275380	14/46 (30%)
		LRR 4	170..190		6/19 (32%)
		LRR 5	193..213		3/19 (16%)
		leucine-rich repeat	194..219	CDD:275380	5/24 (21%)
		LRR 6	219..239		5/19 (26%)
		leucine-rich repeat	220..240	CDD:275380	5/19 (26%)
		LRR 7	240..261		7/23 (30%)
		leucine-rich repeat	241..264	CDD:275380	7/25 (28%)
		LRR 8	264..284		5/19 (26%)
		leucine-rich repeat	265..290	CDD:275380	6/24 (25%)
		LRR 9	290..311		6/20 (30%)
		leucine-rich repeat	291..311	CDD:275380	5/19 (26%)
		leucine-rich repeat	312..335	CDD:275380	8/22 (36%)
		LRR 10	312..332		8/19 (42%)
		LRR 11	335..358		2/22 (9%)
		leucine-rich repeat	336..361	CDD:275380	1/24 (4%)
		LRR 12	361..382		0/20 (0%)
		LRR 13	383..403		5/19 (26%)
		LRR 14	406..427		6/20 (30%)
		leucine-rich repeat	407..503	CDD:275380	29/107 (27%)
		LRR 15	432..453		10/23 (43%)
		LRR 16	477..490		5/12 (42%)
		LRR 17	503..523		4/38 (11%)
		leucine-rich repeat	504..524	CDD:275380	5/38 (13%)
		LRR 18	524..545		3/20 (15%)
		leucine-rich repeat	525..548	CDD:275380	3/22 (14%)
		LRR 19	548..569		4/20 (20%)
		leucine-rich repeat	549..572	CDD:275380	3/22 (14%)
		LRR 20	574..583		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100