DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and FLRT2

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001333072.1	Gene:	FLRT2 / 23768	HGNCID:	3761	Length:	660	Species:	Homo sapiens

Alignment Length:	459	Identity:	103/459 - (22%)
Similarity:	183/459 - (39%)	Gaps:	127/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LYLNGNQLAHIDGSFFRGLHRLSSLS---LQHNRIEFIEMDSFESN--THLRSLRLDQNLLSSLQ 223
            |||:.||:.  :..|...||.:.|:.   |..|     ::|.|..|  .::|.|.|.:|   ::|
Human    68 LYLHNNQIN--NAGFPAELHNVQSVHTVYLYGN-----QLDEFPMNLPKNVRVLHLQEN---NIQ 122

  Fly   224 FLSQRGLARLV---HLNLSSNLLQK--LEPFVFSKNFELQDLDLSYNNITKLNKEALSGLD-SLE 282
            .:|:..||:|:   .|:|..|.:..  :|...|.:...|:.|.||.|:::.:.    .||. .|:
Human   123 TISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQ 183

  Fly   283 RLNISHNYVDKIYDESLDSLIALLQLDISFNLLTT--LPDNLFHFNTQLEEIILANNKIEEISS- 344
            .|.:..|.:..|.|.:..:|.:|.:|.:..||||.  :.:..|...|:|:|..:..|.:.....
Human   184 ELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPD 248

  Fly   345 -------QMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSL------NLS 396
                   ::....|.:.:|.|:  |.|:...|:||           |:|:|:|:.|      |||
Human   249 LPGTHLIRLYLQDNQINHIPLT--AFSNLRKLERL-----------DISNNQLRMLTQGVFDNLS 300

  Fly   397 SLLHFRYINLADNNWSCN----WLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEGGT 457
            :|   :.:...:|.|.|:    | |...::.:|:|:|      |...:.:....|.|:...|...
Human   301 NL---KQLTARNNPWFCDCSIKW-VTEWLKYIPSSLN------VRGFMCQGPEQVRGMAVRELNM 355

  Fly   458 NRSIILLDVSGVP-------------QPKSDNCDCVVAYDETNPS----PPPLTWPKIPT----- 500
            |.........|:|             ||.:        ....|||    ||..|..|:||
Human   356 NLLSCPTTTPGLPLFTPAPSTASPTTQPPT--------LSIPNPSRSYTPPTPTTSKLPTIPDWD 412

  Fly   501 ----------DRF--------DSRSVIIWMLVAIAIAFSGLRWLRRFVDRNEKRKLGQKMLHNVY 547
                      :|.        |:...:.|:.:...:|:. |.|:          |:|..::..:.
Human   413 GRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYK-LTWV----------KMGHSLVGGIV 466

  Fly   548 VSKV 551
            ..::
Human   467 QERI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_RI	115..384	CDD:238064	60/240 (25%)
		LRR_8	135..195	CDD:290566	11/33 (33%)
		leucine-rich repeat	137..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380	7/19 (37%)
		LRR_8	184..243	CDD:290566	18/66 (27%)
		leucine-rich repeat	185..208	CDD:275380	6/27 (22%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	15/62 (24%)
		leucine-rich repeat	233..256	CDD:275380	6/27 (22%)
		leucine-rich repeat	257..280	CDD:275380	7/23 (30%)
		LRR_8	280..339	CDD:290566	17/60 (28%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	7/24 (29%)
FLRT2	NP_001333072.1	LRRNT	35..66	CDD:214470
		NEL	<54..>265	CDD:330839	53/210 (25%)
		LRR 1	64..85		6/18 (33%)
		leucine-rich repeat	65..86	CDD:275378	7/19 (37%)
		LRR 2	89..109		6/24 (25%)
		leucine-rich repeat	90..110	CDD:275380	5/24 (21%)
		LRR 3	110..131		7/23 (30%)
		leucine-rich repeat	111..134	CDD:275380	9/25 (36%)
		LRR 4	134..155		4/20 (20%)
		leucine-rich repeat	135..160	CDD:275380	5/24 (21%)
		LRR 5	160..181		7/24 (29%)
		leucine-rich repeat	161..181	CDD:275380	7/23 (30%)
		leucine-rich repeat	182..205	CDD:275380	6/22 (27%)
		LRR 6	182..202		5/19 (26%)
		LRR 7	205..225		6/19 (32%)
		leucine-rich repeat	206..231	CDD:275380	7/24 (29%)
		LRR 8	231..252		3/20 (15%)
		leucine-rich repeat	232..253	CDD:275380	3/20 (15%)
		LRR_8	252..311	CDD:316378	17/74 (23%)
		LRR 9	253..274		4/22 (18%)
		leucine-rich repeat	254..277	CDD:275380	5/24 (21%)
		LRR 10	277..298		8/31 (26%)
		leucine-rich repeat	278..301	CDD:275380	10/33 (30%)
		PCC	282..>359	CDD:188093	22/86 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413		11/47 (23%)
		fn3	426..494	CDD:306538	7/56 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100