Protein Alignment CG18095 and FLRT3

DIOPT Version :9

• Sequence 1: NP_001188805.1
• Gene: CG18095 / 34823
• FlyBaseID: FBgn0028872
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_037413.1
• Gene: FLRT3 / 23767
• HGNCID: 3762
• Length: 649
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 125/577 - (21%)
• Similarity: 211/577 - (36%)
• Gaps: 197/577 - (34%)

  Fly     4 LPGSLLLLIFSFSP----RLSCLQLSKCNNTEVTLIRKTELLTSLTL---SNCTLPHVENGFFVR 61
            |.|:.:.|....:|    ..||..:.:|:...:..  ....|||:..   .:.|..:::|.
Human    10 LIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYC--NDRFLTSIPTGIPEDATTLYLQNN---- 68

  Fly    62 FDHLLHLELQHSGL-SDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSK 125
                   ::.::|: ||     |..|.|::.:.|.||:|....          |||
Human    69 -------QINNAGIPSD-----LKNLLKVERIYLYHNSLDEFP----------TNL--------- 102

  Fly   126 LSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSL 190
                  .:|  :::|.|:.|.|..|..||...:.:|:.|:|:.|.::.:.
Human   103 ------PKY--VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVS--------------- 144

  Fly   191 QHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNF 255
                   ||..:|..:.:||.|.|.:|.||::.:    ||.|.:
Human   145 -------IEEGAFRDSNYLRLLFLSRNHLSTIPW----GLPRTI--------------------- 177

  Fly   256 ELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDK--IYDESLDSLIALLQLDISFNLLTTL 318
              ::|.|..|.|:.::..:|.||.||:||.:..|.::.  :.|:...:|:.|.:|.:..|.||..
Human   178 --EELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240

  Fly   319 PDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYV 383
            |.||  ..|.|.::.|.:|.|..:..                ||.|....|.||
Human   241 PVNL--PGTNLRKLYLQDNHINRVPP----------------NAFSYLRQLYRL----------- 276

  Fly   384 DLSSNRLKSL---------NLSSLLHFRYINLADNNWSC----NWLVANLVQKLPNSVN----FA 431
            |:|:|.|.:|         |::.|:      |.:|.|.|    .| |.:.:|.||..||    ..
Human   277 DMSNNNLSNLPQGIFDDLDNITQLI------LRNNPWYCGCKMKW-VRDWLQSLPVKVNVRGLMC 334

  Fly   432 RPWTVINNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPLTW- 495
            :....:..::....|.|..||.:.|...:|.:  .:.:|.         ..|......|.|:|.
Human   335 QAPEKVRGMAIKDLNAELFDCKDSGIVSTIQI--TTAIPN---------TVYPAQGQWPAPVTKQ 388

  Fly   496 -----PKIPTDR------------FDSRSV------IIWMLVAIAIAFSGLR--WLR 527
                 ||:..|.            ...:||      |.|.|   |:..:.||  ||:
Human   389 PDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKL---ALPMTALRLSWLK 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/25 (20%)
		LRR_8	64..123	CDD:290566	13/59 (22%)
		leucine-rich repeat	65..88	CDD:275380	5/23 (22%)
		leucine-rich repeat	89..112	CDD:275380	4/22 (18%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		LRR_RI	115..384	CDD:238064	60/270 (22%)
		LRR_8	135..195	CDD:290566	11/59 (19%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	4/22 (18%)
		LRR_8	184..243	CDD:290566	13/58 (22%)
		leucine-rich repeat	185..208	CDD:275380	3/22 (14%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	12/56 (21%)
		leucine-rich repeat	233..256	CDD:275380	0/22 (0%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		LRR_8	280..339	CDD:290566	19/60 (32%)
		leucine-rich repeat	281..304	CDD:275380	6/24 (25%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	5/31 (16%)
		Interaction with ADGRL3. /evidence=ECO:0000269|PubMed:26235030	38..67		4/30 (13%)
		LRR 1. /evidence=ECO:0000255	59..80		5/36 (14%)
		leucine-rich repeat	61..84	CDD:275378	7/38 (18%)
		LRR 2. /evidence=ECO:0000255	84..104		8/44 (18%)
		leucine-rich repeat	85..104	CDD:275380	7/43 (16%)
		LRR 3. /evidence=ECO:0000255	105..126		8/22 (36%)
		LRR_8	106..166	CDD:290566	19/81 (23%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_RI	<120..259	CDD:238064	45/189 (24%)
		LRR 4. /evidence=ECO:0000255	129..150		6/42 (14%)
		leucine-rich repeat	130..155	CDD:275380	7/46 (15%)
		LRR 5. /evidence=ECO:0000255	155..175		9/23 (39%)
		leucine-rich repeat	156..176	CDD:275380	9/23 (39%)
		LRR_8	175..237	CDD:290566	18/84 (21%)
		LRR 6. /evidence=ECO:0000255	176..197		5/43 (12%)
		leucine-rich repeat	177..200	CDD:275380	7/45 (16%)
		LRR 7. /evidence=ECO:0000255	200..220		6/19 (32%)
		leucine-rich repeat	201..226	CDD:275380	6/24 (25%)
		LRR 8. /evidence=ECO:0000255	226..247		8/22 (36%)
		leucine-rich repeat	227..248	CDD:275380	8/22 (36%)
		LRR_8	247..306	CDD:290566	19/91 (21%)
		LRR_4	247..287	CDD:289563	15/66 (23%)
		LRR 9. /evidence=ECO:0000255	248..269		6/36 (17%)
		leucine-rich repeat	249..272	CDD:275380	7/38 (18%)
		LRR 10. /evidence=ECO:0000255	272..293		8/31 (26%)
		leucine-rich repeat	273..296	CDD:275380	8/33 (24%)
		LRRCT	305..356	CDD:214507	13/51 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..407		3/19 (16%)
		fn3	413..478	CDD:278470	10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..649

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010