DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_848793.1	Gene:	Lrrtm3 / 216028	MGIID:	2389177	Length:	582	Species:	Mus musculus

Alignment Length:	459	Identity:	123/459 - (26%)
Similarity:	197/459 - (42%)	Gaps:	110/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFE 204
            |.||||.:.:::.:.|.||:.|..|||:.|.:::||.:.|.|:.||..|.|..|||.:...::|.
Mouse    66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFR 130

  Fly   205 SNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFS--KNFELQDLDLSYNNI 267
            ..|:||:|.|..|.|.||.....|||.:|:.|:|.||.|:.:...:|.  :|.||  |||.||.|
Mouse   131 PVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL--LDLGYNRI 193

  Fly   268 TKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEI 332
            ..|.:...:|:..|:.|::.||...|:                  ||.      ||.....|:.:
Mouse   194 RSLARNVFAGMIRLKELHLEHNQFSKL------------------NLA------LFPRLVSLQNL 234

  Fly   333 ILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAF----LDRLSPSVNRFTLYVDLSSNRLKSL 393
            .:..|||..|...|.:..:.|:.:.||||.|.  ||    :.:..|::.|    ::|.||:|..:
Mouse   235 YMQWNKISVIGQTMSWTWSSLQRLDLSGNEIE--AFSGPSVFQCVPNLQR----LNLDSNKLTFI 293

  Fly   394 N---LSSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLSENT------TNVEG 449
            .   |.|.:....|:||.|.|.|:..:.:|       ||:.|.:   ..|.|||      ..::|
Mouse   294 GQEILDSWISLNDISLAGNIWECSRNICSL-------VNWLRSF---KGLRENTIICASPKELQG 348

  Fly   450 IDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPLTWPKIPTDRFDSR-------- 506
            ::.|:...|.||.         .||...:   .:|.....|.|...||:|..:.:|:
Mouse   349 VNVIDAVKNYSIC---------GKSTTTE---RFDLARALPKPTFKPKLPRPKHESKPPLPPTVG 401

  Fly   507 -----------------------SVIIWMLVAIAIAFSGLRWLR----------RFVDRNEKRKL 538
                                   ||.:::.|.:.:....:.|.|          |.:.|..::|.
Mouse   402 ATEPSPETDVDTEHISFHKIIAGSVALFLSVLVILLVMYVSWKRYPASMKQLQQRSLMRRHRKKK 466

  Fly   539 GQKM 542
            .|.:
Mouse   467 RQSL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_RI	115..384	CDD:238064	80/249 (32%)
		LRR_8	135..195	CDD:290566	22/54 (41%)
		leucine-rich repeat	137..160	CDD:275380	8/19 (42%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		LRR_8	184..243	CDD:290566	25/58 (43%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	11/22 (50%)
		LRR_8	232..289	CDD:290566	20/58 (34%)
		leucine-rich repeat	233..256	CDD:275380	8/24 (33%)
		leucine-rich repeat	257..280	CDD:275380	9/22 (41%)
		LRR_8	280..339	CDD:290566	11/58 (19%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	4/22 (18%)
Lrrtm3	NP_848793.1	LRRNT	33..61	CDD:214470
		LRR 1	63..83		6/16 (38%)
		leucine-rich repeat	66..86	CDD:275380	8/19 (42%)
		LRR_RI	<81..300	CDD:238064	80/250 (32%)
		LRR_8	86..145	CDD:290566	23/58 (40%)
		LRR 2	86..107		8/20 (40%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	110..131		8/20 (40%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR_8	133..193	CDD:290566	27/61 (44%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	11/22 (50%)
		LRR 5	158..179		7/20 (35%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR_8	181..241	CDD:290566	22/85 (26%)
		LRR 6	182..203		10/22 (45%)
		leucine-rich repeat	183..206	CDD:275380	10/24 (42%)
		LRR 7	206..226		8/43 (19%)
		leucine-rich repeat	207..230	CDD:275380	9/46 (20%)
		LRR_8	230..290	CDD:290566	19/65 (29%)
		LRR 8	230..251		6/20 (30%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 9	254..275		8/22 (36%)
		leucine-rich repeat	255..279	CDD:275380	8/25 (32%)
		LRR 10	279..300		6/24 (25%)
		leucine-rich repeat	280..300	CDD:275380	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410		5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910