DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and iglr-1

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_510491.2	Gene:	iglr-1 / 184720	WormBaseID:	WBGene00008977	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	128/494 - (25%)
Similarity:	193/494 - (39%)	Gaps:	113/494 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLIFSFSPRLSCLQLSKCNNTEV--TLIRKTELLTSLTL---------SNCTLPHVENGFFVR- 61
            :..|..|:..::|.....||.:.:  |.:.|.||...|.:         ::.:|..::| |::|
Worm    10 IFFISLFNKAIACPLGCSCNESSISCTFLTKPELYVFLEVLKDSPFNETTDLSLASIDN-FWLRM 73

  Fly    62 ---FDHLLHLELQHSGLSDLDDFSL--NGLTKLQYLSLSHNNLSSLRSWSSEPLGALTN---LDL 118
               ...|..|::|.|...|..|:.|  |...:||.|   |....||::: .:.|.|||:   |||
Worm    74 LPDMPKLRVLKVQSSPSLDDSDWFLRRNQFPELQTL---HFKNCSLKTF-PKALMALTSLLELDL 134

  Fly   119 SHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLH 183
            |.|||..|...|. ....:|::.||.|:|..|....|..:..||.|.|:||.:..:..|.|....
Worm   135 SDNMLENLGADSI-HIRSIQRVILRNNQIKSIGVHVFRYMPTLKMLDLSGNNMTRLVTSDFTSAV 198

  Fly   184 RLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEP 248
            .|..|.|:.|:||.||.|:.|....|.:|.|..||||.::..:|:....|..||||.|.||
Worm   199 SLRELILRENKIELIETDTTEPMQQLETLDLSGNLLSEVRLEAQQNFRHLFSLNLSCNPLQ---- 259

  Fly   249 FVFSKNF----ELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLD 309
             :..:.|    :||.|.|...||:.:...|...|..|..::|..|
Worm   260 -IIREGFLQLPDLQVLQLDNCNISVVEAGAFVSLPRLHSMDIKDN-------------------- 303

  Fly   310 ISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRY---IKLSGNAISDAAFLDR 371
                      .||.:|                  |...|:.|...|   |:.||........|::
Worm   304 ----------PNLAYF------------------SPYAFSNNTAFYRMNIQNSGFKRIPLTILEK 340

  Fly   372 LSPSVNRFTLYVDLSSNRLK-SLNLSSLLHFRYINLAD-NNWSCNWLVANLVQKL--------PN 426
            :|      .||:  ...:|. |.....:..:..|.:.| |:.:|...: ..||||        |.
Worm   341 IS------QLYI--KGTQLDCSCTSRDMQDYGAITIVDWNDATCKTKI-GAVQKLSHLEKTGEPC 396

  Fly   427 SVNFARPWTVINNLSENTTNV---EGIDCIEGGTNRSII 462
            ..|...|:.:     ..|..|   ..|.|...|||..::
Worm   397 RDNLLTPFGI-----RQTATVGHSYRIYCANDGTNSKLL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	5/35 (14%)
		LRR_8	64..123	CDD:290566	23/63 (37%)
		leucine-rich repeat	65..88	CDD:275380	8/24 (33%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	11/25 (44%)
		LRR_RI	115..384	CDD:238064	76/278 (27%)
		LRR_8	135..195	CDD:290566	19/59 (32%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	24/58 (41%)
		leucine-rich repeat	185..208	CDD:275380	10/22 (45%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..289	CDD:290566	19/60 (32%)
		leucine-rich repeat	233..256	CDD:275380	9/26 (35%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		LRR_8	280..339	CDD:290566	6/58 (10%)
		leucine-rich repeat	281..304	CDD:275380	3/22 (14%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
iglr-1	NP_510491.2	LRR	<104..325	CDD:227223	79/278 (28%)
		leucine-rich repeat	106..128	CDD:275380	9/25 (36%)
		leucine-rich repeat	129..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..199	CDD:275380	8/22 (36%)
		leucine-rich repeat	200..223	CDD:275380	10/22 (45%)
		leucine-rich repeat	224..247	CDD:275380	8/22 (36%)
		leucine-rich repeat	248..270	CDD:275380	9/26 (35%)
		leucine-rich repeat	271..294	CDD:275380	8/22 (36%)
		leucine-rich repeat	295..316	CDD:275380	8/68 (12%)
		leucine-rich repeat	320..343	CDD:275380	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910