DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and lron-11

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_491035.1	Gene:	lron-11 / 171837	WormBaseID:	WBGene00022129	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	426	Identity:	121/426 - (28%)
Similarity:	199/426 - (46%)	Gaps:	64/426 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQH 72
            :|:|:...|..:||....|| .|:.|.:.|...|.|:.:.
Worm     5 VLILLVLVSGVISCQSGCKC-PTKTTAVCKGSSLRSIPIL------------------------- 43

  Fly    73 SGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLD---LSHNMLSKLSVKSFEQY 134
                 ||       .:...|.||:|.:|.|   |::.|....||:   |.:|.::.||...|...
Worm    44 -----LD-------PRTTVLDLSNNRISRL---SADELSLYPNLEQLILHNNSITHLSADVFSTL 93

  Fly   135 PQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIE 199
            |.|:.|||..|.:..:.|:.|..|.:||.|.::.|.: .:....|.||.:|.:||:..||:.|:.
Worm    94 PSLRVLDLSSNSLLSLPNEVFSKLKNLKTLIISSNDV-QLGPECFAGLSQLQTLSIADNRLSFLP 157

  Fly   200 MDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSY 264
            ....:..:.||:|.|..|.|.|:.......|..|..|.|..|||..||..:|....||:.||:|.
Worm   158 PSVLKPLSGLRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSE 222

  Fly   265 NNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQL 329
            |.|..:.:.||.||:.||.||:::|.:.::...:. ||.||..||:|.||..:|....|.....|
Worm   223 NLIGDIEEGALYGLEKLETLNLTNNQLVRLPGNTW-SLPALKTLDLSSNLFVSLETASFDGLPAL 286

  Fly   330 EEIILANNK-IEEISSQMMFNQNHLRYIKLSGNA---ISDAAF--LDRLSPSVNRFTLYVDLSSN 388
            :.:.::::: ::.|........:.|.::.:|.:|   |..:||  :..||        ::|||:|
Worm   287 QYLNISHSRNLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLS--------HLDLSNN 343

  Fly   389 RLKSLNLSSLL--HFRYINLADNNW--SCNWLVANL 420
            .|:.:....|.  :.|.::||:|:|  ||:..|:||
Worm   344 ELRYVAPGMLQWPNIRNLHLANNDWHCSCDLRVSNL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	2/22 (9%)
		LRR_8	64..123	CDD:290566	14/61 (23%)
		leucine-rich repeat	65..88	CDD:275380	2/22 (9%)
		leucine-rich repeat	89..112	CDD:275380	8/22 (36%)
		leucine-rich repeat	113..136	CDD:275380	7/25 (28%)
		LRR_RI	115..384	CDD:238064	83/277 (30%)
		LRR_8	135..195	CDD:290566	20/59 (34%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	18/58 (31%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..289	CDD:290566	24/56 (43%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	10/22 (45%)
		LRR_8	280..339	CDD:290566	17/59 (29%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
lron-11	NP_491035.1	leucine-rich repeat	48..71	CDD:275380	8/25 (32%)
		LRR_RI	<50..177	CDD:238064	42/130 (32%)
		LRR_8	70..130	CDD:290566	20/59 (34%)
		leucine-rich repeat	72..95	CDD:275380	6/22 (27%)
		leucine-rich repeat	96..119	CDD:275380	8/22 (36%)
		LRR_8	118..177	CDD:290566	18/59 (31%)
		leucine-rich repeat	120..142	CDD:275380	7/22 (32%)
		LRR_RI	<141..270	CDD:238064	46/129 (36%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..190	CDD:275380	8/22 (36%)
		LRR_8	190..249	CDD:290566	25/58 (43%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	10/22 (45%)
		LRR_8	238..295	CDD:290566	17/57 (30%)
		leucine-rich repeat	239..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..283	CDD:275380	8/20 (40%)
		LRR_8	284..345	CDD:290566	14/68 (21%)
		leucine-rich repeat	286..310	CDD:275380	2/23 (9%)
		leucine-rich repeat	311..334	CDD:275380	6/22 (27%)
		leucine-rich repeat	335..357	CDD:275380	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910