Protein Alignment CG18095 and LGI4

DIOPT Version :10

• Sequence 1: NP_001188805.1
• Gene: CG18095 / 34823
• FlyBaseID: FBgn0028872
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_644813.1
• Gene: LGI4 / 163175
• HGNCID: 18712
• Length: 537
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 53/181 - (29%)
• Similarity: 88/181 - (48%)
• Gaps: 28/181 - (15%)

  Fly   113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGS 177
            |.:|.|....:::|...||.:.|.|..|....|..|.||:|:|.|||||::|::..|::..|..:
Human    54 LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKN 118

  Fly   178 FFRGLHRLSSLSLQHNRIEFIEMDSF---ESNTHL----RSLRLDQNLLSSLQFL---------- 225
            ..|||..|:.|||.:|.:|.:....|   ::.||:    ...:.|..:|..||::
Human   119 ALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTG 183

  Fly   226 SQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALS 276
            :..|.|.|.|:.     |..|:|    |.|:.:.::||:  ...:.:.|||
Human   184 ACAGPASLSHMQ-----LHHLDP----KTFKCRAIELSW--FQTVGESALS 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	LRR	22..>338	CDD:443914	53/181 (29%)
		leucine-rich repeat	41..64	CDD:275380
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		leucine-rich repeat	137..160	CDD:275380	10/22 (45%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	7/25 (28%)
		leucine-rich repeat	209..232	CDD:275380	5/36 (14%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	5/20 (25%)
		leucine-rich repeat	281..304	CDD:275380
		leucine-rich repeat	305..328	CDD:275380
LGI4	NP_644813.1	leucine-rich repeat	29..53	CDD:275380
		LRR 1	53..74		6/19 (32%)
		leucine-rich repeat	54..77	CDD:275378	6/22 (27%)
		LRR_8	76..136	CDD:404697	25/59 (42%)
		LRR 2	77..98		8/20 (40%)
		leucine-rich repeat	78..101	CDD:275378	10/22 (45%)
		LRR 3	101..122		5/20 (25%)
		leucine-rich repeat	102..125	CDD:275378	7/22 (32%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..149	CDD:275378	7/22 (32%)
		PCC	131..>206	CDD:188093	19/83 (23%)
		leucine-rich repeat	150..162	CDD:275378	2/11 (18%)
		leucine-rich repeat	167..205	CDD:275380	11/46 (24%)
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	210..252		5/16 (31%)
		EPTP	214..250	CDD:461033	3/10 (30%)
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	256..298
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	302..349
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	351..394
		EPTP	351..392	CDD:461033
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	396..439
		EPTP	396..437	CDD:461033
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	441..483
		EPTP	441..480	CDD:461033
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	487..532