Protein Alignment CG18095 and CHADL

DIOPT Version :10

• Sequence 1: NP_001188805.1
• Gene: CG18095 / 34823
• FlyBaseID: FBgn0028872
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_054181131.1
• Gene: CHADL / 150356
• HGNCID: 25165
• Length: 771
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 145/698 - (20%)
• Similarity: 227/698 - (32%)
• Gaps: 250/698 - (35%)

  Fly     3 LLPGSLLLLIFSFSPRLS----CLQLSKCNN------------TEV-----TLIRKTEL------ 40
            :||  ||:|:.....|.:    |.|...|:|            |||     .|.::.:|
Human    13 VLP--LLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLK 75

  Fly    41 ------------LTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLS 93
                        ||.|.|.:|.:..|..|.|.....||.|.|..:.|.:|...:|:||..|:.|.
Human    76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLE 140

  Fly    94 LSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGL 158
            |..|.|..||..:...||||..|:|:||.|..|...:|:...:::.|.|.:|.:|.:..::..||
Human   141 LEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGL 205

  Fly   159 SHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQ 223
            ..|:.|.|:.|:|..:.|........|:.|.|.||.:.:...:...:...||.|.||.   .:||
Human   206 PALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDG---GALQ 267

  Fly   224 FLSQRGLA---RLVHLNLSSNLLQKLEPF------------------------------------ 249
            .|..|..|   ||..|:|..|.|..|.|.
Human   268 ALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS 332

  Fly   250 ----------------------------VFSKNFELQD--------------------------- 259
                                        ...:..||::
Human   333 DGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCP 397

  Fly   260 --------------------------------LDLSYNNITKLNKEALSGLDSLERLNISHNYVD 292
                                            |||..|:...:.:.|..||..|..|::.|..:.
Human   398 RACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIA 462

  Fly   293 KIYDESLDSLIALLQLDISFNLLTTL------------------------PDNLFHFNTQLEEII 333
            ::...:|..|..|:.|.:|.|.|..|                        |.........|..:.
Human   463 ELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLH 527

  Fly   334 LANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVD-------------- 384
            |.:|.::.::...:.....||::.||||.|::.: |..|.|:.....|::|
Human   528 LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS-LGALGPARELEKLHLDRNQLREVPTGALEG 591

  Fly   385 --------LSSNRLKSLNLS-------SLLHFRYINLADNNWSCNWLVANL---VQKLPNSVNFA 431
                    ||.|.|::|...       ||.|. ::|.:.....|....:.|   :|.|....|..
Human   592 LPALLELQLSGNPLRALRDGAFQPVGRSLQHL-FLNSSGLEQICPGAFSGLGPGLQSLHLQKNQL 655

  Fly   432 RPWTVINNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDC 479
            |....:.:||:                  :.|:|:|..|    .:|||
Human   656 RALPALPSLSQ------------------LELIDLSSNP----FHCDC 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	LRR	22..>338	CDD:443914	101/500 (20%)
		leucine-rich repeat	41..64	CDD:275380	8/22 (36%)
		leucine-rich repeat	65..88	CDD:275380	9/22 (41%)
		leucine-rich repeat	89..112	CDD:275380	8/22 (36%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	10/25 (40%)
		leucine-rich repeat	233..256	CDD:275380	7/86 (8%)
		leucine-rich repeat	257..280	CDD:275380	8/81 (10%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	7/46 (15%)
CHADL	XP_054181131.1	LRRNT	33..65	CDD:214470	8/31 (26%)
		leucine-rich repeat	44..62	CDD:275380	3/17 (18%)
		leucine-rich repeat	64..87	CDD:275380	1/22 (5%)
		LRR_8	65..146	CDD:404697	22/80 (28%)
		leucine-rich repeat	88..135	CDD:275380	17/46 (37%)
		LRR	<128..>312	CDD:443914	56/186 (30%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		leucine-rich repeat	160..183	CDD:275380	8/22 (36%)
		leucine-rich repeat	184..207	CDD:275380	6/22 (27%)
		leucine-rich repeat	208..231	CDD:275380	6/22 (27%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		leucine-rich repeat	256..279	CDD:275380	10/25 (40%)
		LRRNT	395..429	CDD:214470	0/33 (0%)
		leucine-rich repeat	410..426	CDD:275380	0/15 (0%)
		leucine-rich repeat	427..450	CDD:275380	7/22 (32%)
		LRR	<445..>677	CDD:443914	50/255 (20%)
		leucine-rich repeat	451..474	CDD:275380	5/22 (23%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		leucine-rich repeat	499..522	CDD:275380	1/22 (5%)
		leucine-rich repeat	523..546	CDD:275380	3/22 (14%)
		leucine-rich repeat	547..570	CDD:275380	10/23 (43%)
		leucine-rich repeat	571..594	CDD:275380	2/22 (9%)
		leucine-rich repeat	595..619	CDD:275380	5/23 (22%)
		leucine-rich repeat	620..644	CDD:275380	5/24 (21%)
		LRRCT	675..723	CDD:214507	4/11 (36%)