DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and CPN2

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens

Alignment Length:	597	Identity:	151/597 - (25%)
Similarity:	229/597 - (38%)	Gaps:	120/597 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLPGSLLL---LIFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDH 64
            :|||:.||   |:....|...|.....|...||  ....|.|.::.|.  ..|:.:|..||.
Human     1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEV--FCSDEELATVPLD--IPPYTKNIIFVE--- 58

  Fly    65 LLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVK 129
                               ...|.|:           .|::.|.|  .||.:...:..|.:....
Human    59 -------------------TSFTTLE-----------TRAFGSNP--NLTKVVFLNTQLCQFRPD 91

  Fly   130 SFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNR 194
            :|...|:|:.|::..:....:..:.|..|:.|..|.||.|.|..:....|:.|..|.||.||.|:
Human    92 AFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQ 156

  Fly   195 IEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQD 259
            ::.:....|:..|||::|.|.||||:.|.......|..|..|.||:|.|..|...||.|...||:
Human   157 LQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221

  Fly   260 LDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFH 324
            |.|..|||::|..:..|.|..||||.:..|.:..:......||..|..|.:.:|:|..||..||.
Human   222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFA 286

  Fly   325 FNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAIS--------DAAFLDRLSPSVNRFT- 380
            ....|..:.|.:|::|.::.....:.::||.:.||.|||:        |...|.:|....|..|
Human   287 HTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTA 351

  Fly   381 ----LYVDLSSNRLKSLNLSSL---------LHFRYINLA--DNNWSCNWLVANLVQKLPNSVNF 430
                |:.:||...|.||:.:.|         .::...|||  .|.|.|:..:|.|       .|:
Human   352 LHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYL-------FNW 409

  Fly   431 ARPWTVINNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPLTW 495
            .:.:|  :.|....|...|...::|..           ||........|.|..|.....   :||
Human   410 LQQYT--DRLLNIQTYCAGPAYLKGQV-----------VPALNEKQLVCPVTRDHLGFQ---VTW 458

  Fly   496 PKIPTDRFDSRSVIIWML-------------------VAIAIAFSGLRWLRRFVDRNEKRKLGQK 541
            |.      :|::...|.|                   |.:|...:..|||      |.:....|.
Human   459 PD------ESKAGGSWDLAVQERAARSQCTYSNPEGTVVLACDQAQCRWL------NVQLSPQQG 511

  Fly   542 MLHNVYVSKVQW 553
            .|...|.:..:|
Human   512 SLGLQYNASQEW 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	6/22 (27%)
		LRR_8	64..123	CDD:290566	7/58 (12%)
		leucine-rich repeat	65..88	CDD:275380	0/22 (0%)
		leucine-rich repeat	89..112	CDD:275380	4/22 (18%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		LRR_RI	115..384	CDD:238064	85/281 (30%)
		LRR_8	135..195	CDD:290566	19/59 (32%)
		leucine-rich repeat	137..160	CDD:275380	4/22 (18%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	23/58 (40%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	24/56 (43%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	10/22 (45%)
		LRR_8	280..339	CDD:290566	18/58 (31%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	8/35 (23%)
		leucine-rich repeat	30..53	CDD:275380	6/26 (23%)
		leucine-rich repeat	75..98	CDD:275380	4/22 (18%)
		LRR 1	98..119		3/20 (15%)
		leucine-rich repeat	99..122	CDD:275380	4/22 (18%)
		LRR_8	121..181	CDD:290566	22/59 (37%)
		LRR 2	122..143		7/20 (35%)
		leucine-rich repeat	123..146	CDD:275380	8/22 (36%)
		LRR 3	146..167		7/20 (35%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		LRR_RI	149..>356	CDD:238064	68/206 (33%)
		LRR_8	169..229	CDD:290566	26/59 (44%)
		LRR 4	170..191		9/20 (45%)
		leucine-rich repeat	171..194	CDD:275380	9/22 (41%)
		LRR 5	194..215		9/20 (45%)
		leucine-rich repeat	195..218	CDD:275380	10/22 (45%)
		LRR_8	218..277	CDD:290566	20/58 (34%)
		LRR 6	218..239		8/20 (40%)
		leucine-rich repeat	219..242	CDD:275380	10/22 (45%)
		LRR 7	242..263		5/20 (25%)
		leucine-rich repeat	243..266	CDD:275380	7/22 (32%)
		LRR 8	266..287		8/20 (40%)
		leucine-rich repeat	267..290	CDD:275380	8/22 (36%)
		LRR 9	290..311		4/20 (20%)
		leucine-rich repeat	291..314	CDD:275380	4/22 (18%)
		LRR_8	294..349	CDD:290566	14/54 (26%)
		LRR 10	314..335		7/20 (35%)
		leucine-rich repeat	315..338	CDD:275380	8/22 (36%)
		LRR 11	338..359		5/20 (25%)
		leucine-rich repeat	339..359	CDD:275380	5/19 (26%)
		LRR 12	362..383		4/20 (20%)
		leucine-rich repeat	363..382	CDD:275380	4/18 (22%)
		leucine-rich repeat	387..399	CDD:275378	5/11 (45%)
		LRRCT	395..446	CDD:214507	13/70 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840