DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and podn

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_003201285.2	Gene:	podn / 100536479	ZFINID:	ZDB-GENE-100922-117	Length:	593	Species:	Danio rerio

Alignment Length:	345	Identity:	112/345 - (32%)
Similarity:	170/345 - (49%)	Gaps:	33/345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSD--LDDFSLNGLTKLQYLSLSHNNLSSLR 103
            |..|.|.|..|..:.:|.|....||..|.||::.||:  :|:.:.:.|..|:||.||:||||::
Zfish   222 LYRLHLKNNKLEKIPSGAFDNLFHLRELYLQNNFLSNDGMDNETFSHLNSLEYLDLSNNNLSTV- 285

  Fly   104 SWSSEPLGALTNLDLSH---NMLSKLSVKSFEQYPQLQQLDLRYNRI--SQIENDSFDGLSHLKH 163
                 |||...|:.|.|   |.:..::|.:......|:.|.|..||:  ..|...:|.||..|..
Zfish   286 -----PLGLPRNVILLHLEKNSIQSIAVNALSPIRNLEYLLLHNNRLRSRSIHPAAFQGLKRLHT 345

  Fly   164 LYLNGNQLAHIDGSFFRGL-HRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQ 227
            :::..|.|..:.    ||| .|..:|.|.||.|..|..:...:...|..|.|..|.|:|.:...:
Zfish   346 VHMYNNLLERVP----RGLPRRAKTLMLLHNLISEIGRNDLITLYTLTELNLSYNRLTSAKLHRE 406

  Fly   228 --RGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNY 290
              |.|..|..|:||.|.||.| |....|:  ||.|.:..|.:|::.:.||.|:.||..|.:::|.
Zfish   407 AFRKLRILETLDLSGNKLQAL-PLGLPKS--LQILKVKDNQMTEIPEGALLGMTSLRELYLTNNQ 468

  Fly   291 --VDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNH- 352
              :..||..:...:.||..||:|.|:|:.:|.:|   ...||.:.|.||:|..||.....|..:
Zfish   469 LKLSSIYQGAWLEMNALKTLDLSGNMLSHIPPDL---PESLEFLHLQNNRINSISETAFLNTPNI 530

  Fly   353 ----LRYIKLSGNAISDAAF 368
                ||:.:||.|::|:..|
Zfish   531 KGIFLRFNRLSVNSVSEETF 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/22 (32%)
		LRR_8	64..123	CDD:290566	25/63 (40%)
		leucine-rich repeat	65..88	CDD:275380	8/24 (33%)
		leucine-rich repeat	89..112	CDD:275380	11/22 (50%)
		leucine-rich repeat	113..136	CDD:275380	5/25 (20%)
		LRR_RI	115..384	CDD:238064	84/269 (31%)
		LRR_8	135..195	CDD:290566	20/62 (32%)
		leucine-rich repeat	137..160	CDD:275380	9/24 (38%)
		leucine-rich repeat	161..184	CDD:275380	6/23 (26%)
		LRR_8	184..243	CDD:290566	20/60 (33%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	8/24 (33%)
		LRR_8	232..289	CDD:290566	21/56 (38%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		LRR_8	280..339	CDD:290566	20/60 (33%)
		leucine-rich repeat	281..304	CDD:275380	5/24 (21%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
podn	XP_003201285.2	LRRNT	50..80	CDD:214470
		leucine-rich repeat	80..103	CDD:275380
		LRR_RI	<81..282	CDD:238064	22/59 (37%)
		LRR_8	83..140	CDD:290566
		leucine-rich repeat	104..129	CDD:275380
		leucine-rich repeat	130..174	CDD:275380
		LRR_8	173..254	CDD:290566	12/31 (39%)
		leucine-rich repeat	175..200	CDD:275380
		leucine-rich repeat	201..221	CDD:275380
		LRR_RI	219..496	CDD:238064	93/286 (33%)
		LRR_8	222..282	CDD:290566	22/59 (37%)
		leucine-rich repeat	222..245	CDD:275380	7/22 (32%)
		leucine-rich repeat	246..271	CDD:275380	8/24 (33%)
		leucine-rich repeat	272..292	CDD:275380	12/25 (48%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		LRR_8	315..398	CDD:290566	26/86 (30%)
		leucine-rich repeat	317..342	CDD:275380	9/24 (38%)
		leucine-rich repeat	343..387	CDD:275380	13/47 (28%)
		LRR_8	387..469	CDD:290566	30/84 (36%)
		leucine-rich repeat	388..413	CDD:275380	8/24 (33%)
		leucine-rich repeat	414..434	CDD:275380	9/20 (45%)
		leucine-rich repeat	435..458	CDD:275380	8/22 (36%)
		LRR_8	457..516	CDD:290566	20/61 (33%)
		leucine-rich repeat	485..505	CDD:275380	8/22 (36%)
		LRR_8	505..566	CDD:290566	16/46 (35%)
		leucine-rich repeat	506..524	CDD:275380	8/17 (47%)
		leucine-rich repeat	530..555	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100