DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	341	Identity:	93/341 - (27%)
Similarity:	144/341 - (42%)	Gaps:	79/341 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLIFSFSPRL-----SCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLH 67
            |||......|||     :|..|..|:|....:|             ||
Zfish    21 LLLWPHLLGPRLAEASPACPALCSCSNQASRVI-------------CT----------------- 55

  Fly    68 LELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFE 132
                ...|:::.. |::..|:  ||:|..|::..:||.:.:.|..|..|.||.|.:.::.|.:|.
Zfish    56 ----KKSLNEVPQ-SISSNTR--YLNLQENSIQVIRSDTFKHLNHLEILQLSKNQIRQIEVGAFN 113

  Fly   133 QYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEF 197
            ..|.|..|:|..||:..:.:.:|:.||.|:.|:|..|.:..:....|   ||:.||.
Zfish   114 GLPNLITLELFDNRLPLVPSQAFEYLSKLRELWLRNNPIETLPAYAF---HRVPSLR-------- 167

  Fly   198 IEMDSFESNTHLRSLRLDQNLLSSLQFLSQ---RGLARLVHLNLSSNLLQ---KLEPFVFSKNFE 256
                           |||...|..|.|:|:   .||..|..|||....|:   .|.|.|     .
Zfish   168 ---------------RLDLGELRKLSFISEAAFEGLLNLRFLNLGMCGLKDVPNLTPLV-----R 212

  Fly   257 LQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDN 321
            |::|:||.|.:..:...:..||.||.:|.:.|:.:..|...:.|.|..|.:|::|.|.|.:||.:
Zfish   213 LEELELSGNQLGVVRPGSFQGLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHSLPHD 277

  Fly   322 LFHFNTQLEEIILANN 337
            ||....|||.:.|.:|
Zfish   278 LFTPLQQLERVHLNHN 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	2/22 (9%)
		LRR_8	64..123	CDD:290566	15/58 (26%)
		leucine-rich repeat	65..88	CDD:275380	2/22 (9%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	69/229 (30%)
		LRR_8	135..195	CDD:290566	18/59 (31%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	5/22 (23%)
		LRR_8	184..243	CDD:290566	16/61 (26%)
		leucine-rich repeat	185..208	CDD:275380	2/22 (9%)
		leucine-rich repeat	209..232	CDD:275380	9/25 (36%)
		LRR_8	232..289	CDD:290566	18/59 (31%)
		leucine-rich repeat	233..256	CDD:275380	8/25 (32%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		LRR_8	280..339	CDD:290566	21/58 (36%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	10/70 (14%)
		LRR_8	68..128	CDD:290566	20/61 (33%)
		leucine-rich repeat	70..93	CDD:275380	8/24 (33%)
		LRR_RI	85..293	CDD:238064	71/238 (30%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		LRR_8	140..196	CDD:290566	21/81 (26%)
		leucine-rich repeat	142..165	CDD:275380	7/25 (28%)
		leucine-rich repeat	166..190	CDD:275380	10/46 (22%)
		leucine-rich repeat	191..212	CDD:275380	8/25 (32%)
		LRR_8	212..271	CDD:290566	18/58 (31%)
		leucine-rich repeat	213..236	CDD:275380	7/22 (32%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..282	CDD:275380	9/20 (45%)
		TPKR_C2	293..343	CDD:301599	1/1 (100%)
		IG_like	352..435	CDD:214653
		Ig	360..435	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000