DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18095 and tril

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_002933436.2	Gene:	tril / 100498304	XenbaseID:	XB-GENE-6050227	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	136/519 - (26%)
Similarity:	215/519 - (41%)	Gaps:	95/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KTELLTSLTLSNCTLPH-VENGFFVRFD--HLLHLELQHSGLSDLDDFSLNGLTKLQYLSL--SH 96
            |..|:..|.|..|||.. ||.......|  |..|:...:.||                ||:  |.
Frog     3 KAALVEVLVLLTCTLARSVEPKCLEPCDCQHQQHVLCSNRGL----------------LSVPKSS 51

  Fly    97 NNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHL 161
            :.|||         .|.....|..|.::.:|...|.|:||||:|||:||||..|...:|:.|:.|
Frog    52 HMLSS---------SATKTFSLGGNFIANISALDFVQFPQLQRLDLQYNRIGSIHPKAFEKLTEL 107

  Fly   162 KHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLS 226
            :.|||..|.||.:.......|.:|..|::..||:..|...||.:...|..||||.|.:.:||...
Frog   108 EELYLGNNLLATLAPGALAPLRKLKVLNVNGNRLHNISRVSFSNLAALIKLRLDGNDIQNLQGSP 172

  Fly   227 QRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYV 291
            ...|:.|::|:|.:|.:..:....|:...:|:.|.||.|..:.|.:.....|.:|..|.::.|.:
Frog   173 FSALSNLLYLHLENNKITNISKNAFTGLGKLRLLSLSGNPQSFLRQPTFLPLRALSTLTMAGNQL 237

  Fly   292 DKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYI 356
            .::.....:.|..|.:|.:|.|.::.:....|.....|:|:.|..||:.::...::...::|..:
Frog   238 QQLGPSLFNGLQRLSRLVLSSNQISVIQTKTFLGLDLLQELHLDGNKLVQLPEGVLVPLHNLEVL 302

  Fly   357 KLSGNAISDAAFLDRLSPSVNRFTL---YVDLSSNRLKSLN----LSSLLHFRYINLADNNWSC- 413
            .||.||||      .|.|...:..:   .:||..|.|:.|:    ..:.:.:| :.|..|.|||
Frog   303 NLSRNAIS------HLHPETFKGLMRLRVLDLQHNMLRYLSGQTFAGNPVLYR-LQLDGNRWSCD 360

  Fly   414 -------NWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEG--IDCIE-------GGTNRSI- 461
                   :|::..|..:       :|..||.....| ...|.|  :|.:|       ||...|.
Frog   361 CQLLDLKHWILGTLHSR-------SRMLTVFVQCFE-PQKVAGKYLDYLEDSYLWDVGGCRISTT 417

  Fly   462 ----------ILLDVS-GVPQPKSDNCDCVVAYDETN--------------PSPPPLTWPKIPT 500
                      .|.|.: ||.|.:..:.|.:|.....|              |:||....|.:.|
Frog   418 PAGQEQMMTSTLSDGNIGVHQARKGDIDLIVVTGADNLRVQPKTEEKSLQLPTPPSEVSPALET 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	8/25 (32%)
		LRR_8	64..123	CDD:290566	13/60 (22%)
		leucine-rich repeat	65..88	CDD:275380	3/22 (14%)
		leucine-rich repeat	89..112	CDD:275380	6/24 (25%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	115..384	CDD:238064	78/271 (29%)
		LRR_8	135..195	CDD:290566	25/59 (42%)
		leucine-rich repeat	137..160	CDD:275380	12/22 (55%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	20/58 (34%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_8	232..289	CDD:290566	14/56 (25%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		LRR_8	280..339	CDD:290566	13/58 (22%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..328	CDD:275380	5/22 (23%)
tril	XP_002933436.2	leucine-rich repeat	35..58	CDD:275378	9/47 (19%)
		leucine-rich repeat	59..82	CDD:275380	5/22 (23%)
		leucine-rich repeat	83..106	CDD:275380	12/22 (55%)
		internalin_A	84..>375	CDD:380193	82/297 (28%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		leucine-rich repeat	227..250	CDD:275380	4/22 (18%)
		leucine-rich repeat	251..274	CDD:275380	5/22 (23%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		leucine-rich repeat	299..320	CDD:275380	9/26 (35%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		fn3	662..737	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910