DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and flrt1b

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_005169675.1	Gene:	flrt1b / 100144397	ZFINID:	ZDB-GENE-080327-6	Length:	715	Species:	Danio rerio

Alignment Length:	589	Identity:	138/589 - (23%)
Similarity:	189/589 - (32%)	Gaps:	233/589 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CNNTEVTLIRKTEL------LTSLTLSNCTLP-HVENGFFVRFDHLLHLELQHSGLSDLDDFSLN 84
            ||:..:|||....|      |.:..:.|..|| .:|....||..:|..        ::||||..:
Zfish    65 CNDRGLTLIPPLPLTAAVLYLQNNRIDNAGLPTSLERRLTVRVVYLYD--------NELDDFPTH 121

  Fly    85 GLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRIS- 148
            ....|:.|.|..||:.:|      |..||..|                  |.|::|.:..|.||
Zfish   122 LPPSLRELHLQDNNIRTL------PRSALARL------------------PLLEKLHMDDNSIST 162

  Fly   149 -QIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSL 212
             .||:.:|.....|:.|:|:.|.|:.|..    ||                       ...|..|
Zfish   163 VSIEDKAFTNNPRLRLLFLSRNHLSSIPS----GL-----------------------PASLEEL 200

  Fly   213 RLDQNLLSSLQFLSQRGLARLVHLNLSSNLL--QKLEPFVFSKNFELQDLDLSYNNI--TKLNKE 273
            |||.|.:|::...:.|||:.|..|.|..|||  |::....||:...|.:|.|..|::  ..||..
Zfish   201 RLDDNRISTIPTHAFRGLSSLRRLFLDGNLLANQRIADDTFSRLSNLTELSLVRNSLQAPPLNLP 265

  Fly   274 ALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNK 338
            :|    .|.||.:..|.:..:...|||.:..|.:||||.|.|||||..||.
Zfish   266 SL----HLLRLYLQDNAIAHMPRGSLDGMRRLQKLDISGNNLTTLPRGLFK-------------- 312

  Fly   339 IEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLNLSSLLHFRY 403
                                                         ||.|       ||.||
Zfish   313 ---------------------------------------------DLDS-------LSQLL---- 321

  Fly   404 INLADNNWSC----NWLVANLVQKLPNSVNFARPWTVINNLSE--NTTNVEGIDCIEGGTNRSII 462
              :..|.|.|    .||               ..|     |.|  ::..|.|:.|......|.:.
Zfish   322 --VRGNPWYCGCNLRWL---------------HDW-----LHERGSSVTVRGLTCHAPERLRGMA 364

  Fly   463 LLDVSGVPQPKSDNCDCVVAYDETN----------------PSPPPLTWPKIPTDRFDSRSVIIW 511
            |.|:|      |...||.|..|...                ..||..|.|.:|.
Zfish   365 LRDLS------SQLEDCEVTVDAAGGMVGNEVAKKEKGYFPTQPPATTTPPLPQ----------- 412

  Fly   512 MLVAIAIAFSGLRWLRRFVDRNEKRKLGQKML--HNVYVSK---------------VQWQAIRTD 559
                     ..|..||.....::...:||..|  .|.:|||               :.|||.:..
Zfish   413 ---------GSLFTLRSRRPGHKYSDMGQDSLGGGNGFVSKSLLISVKPLTPETVHITWQAAQPV 468

  Fly   560 PDQR 563
            |..|
Zfish   469 PSFR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	7/23 (30%)
		LRR_8	64..123	CDD:290566	15/58 (26%)
		leucine-rich repeat	65..88	CDD:275380	5/22 (23%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	2/22 (9%)
		LRR_RI	115..384	CDD:238064	64/274 (23%)
		LRR_8	135..195	CDD:290566	17/61 (28%)
		leucine-rich repeat	137..160	CDD:275380	8/24 (33%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		LRR_8	184..243	CDD:290566	14/58 (24%)
		leucine-rich repeat	185..208	CDD:275380	0/22 (0%)
		leucine-rich repeat	209..232	CDD:275380	10/22 (45%)
		LRR_8	232..289	CDD:290566	19/60 (32%)
		leucine-rich repeat	233..256	CDD:275380	9/24 (38%)
		leucine-rich repeat	257..280	CDD:275380	7/24 (29%)
		LRR_8	280..339	CDD:290566	20/58 (34%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	13/22 (59%)
flrt1b	XP_005169675.1	LRRNT	51..77	CDD:214470	5/11 (45%)
		leucine-rich repeat	82..104	CDD:275378	5/21 (24%)
		leucine-rich repeat	105..125	CDD:275380	7/27 (26%)
		LRR_RI	<120..305	CDD:238064	67/239 (28%)
		LRR_8	124..186	CDD:290566	23/85 (27%)
		leucine-rich repeat	126..149	CDD:275380	10/46 (22%)
		leucine-rich repeat	150..175	CDD:275380	8/24 (33%)
		LRR_8	174..231	CDD:290566	22/83 (27%)
		leucine-rich repeat	176..196	CDD:275380	8/46 (17%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..246	CDD:275380	9/24 (38%)
		leucine-rich repeat	247..268	CDD:275380	7/24 (29%)
		LRR_8	268..326	CDD:290566	27/129 (21%)
		leucine-rich repeat	269..292	CDD:275380	7/22 (32%)
		leucine-rich repeat	293..316	CDD:275380	15/81 (19%)
		LRRCT	325..375	CDD:214507	16/75 (21%)
		fn3	448..515	CDD:278470	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100