Protein Alignment hll and menE

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_416763.1
• Gene: menE / 946741
• ECOCYCID: EG12437
• Length: 451
• Species: Escherichia coli
• Alignment Length: 575
• Identity: 127/575 - (22%)
• Similarity: 203/575 - (35%)
• Gaps: 170/575 - (29%)

  Fly    49 YSDLPALVW-ETPGSG-----NDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEW 107
            :||.|...| :..|..     ||  ..|.:.|...||::.|......||.|.|.|.:.|:|.|:.
E. coli     3 FSDWPWRHWRQVRGETIALRLND--EQLNWRELCARVDELASGFAVQGVVEGSGVMLRAWNTPQT 65

  Fly   108 FFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAV-IQ 171
            ..|....|:.||.|..|.|......:..:|........:|.|.:         ...|.|.:: ||
E. coli    66 LLAWLALLQCGARVLPVNPQLPQPLLEELLPNLTLQFALVPDGE---------NTFPALTSLHIQ 121

  Fly   172 L-HGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVML 235
            | .|...|         :||                  .:|:    |:|.: |||:.|:|||.:.
E. coli   122 LVEGAHAA---------TWQ------------------PTRL----CSMTL-TSGSTGLPKAAVH 154

  Fly   236 SHDNLVFDTKSAAAHMQDIQVGKESFVSY---------LPLSHVAAQIFDVFLGLSHAGC-VTFA 290
            ::.          ||:...| |..|.:.:         |||.||:.|  .:.....:||. :|..
E. coli   155 TYQ----------AHLASAQ-GVLSLIPFGDHDDWLLSLPLFHVSGQ--GIMWRWLYAGARMTVR 206

  Fly   291 DKDALKGTLIK-TFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTL 354
            ||..|:..|.. |.....||:::                        |||:.|:..::   :..|
E. coli   207 DKQPLEQMLAGCTHASLVPTQLW------------------------RLLVNRSSVSL---KAVL 244

  Fly   355 MAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMS 419
            :.|.:          :...:.:..||. |: .|                 |.|        ||::
E. coli   245 LGGAA----------IPVELTEQAREQ-GI-RC-----------------FCG--------YGLT 272

  Fly   420 ETSGAITLNVDISNLYSAGQACEGVTLKIHEPDCNGQGEILMRGRLVFMGYLGLPDKTEETVKED 484
            |.:..:... :...|...|....|..:||      ...|:.:|...:..|| ....:....|.::
E. coli   273 EFASTVCAK-EADGLADVGSPLPGREVKI------VNNEVWLRAASMAEGY-WRNGQLVSLVNDE 329

  Fly   485 GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLT 549
            ||..:.|.|.:. .|.|.|.|||..|.. :|||.|.|..:|.:|... |.|..|.::
E. coli   330 GWYATRDRGEMH-NGKLTIVGRLDNLFF-SGGEGIQPEEVERVIAAH-PAVLQVFIV-------- 383

  Fly   550 VLLSLKTKCDAKTGIPLDALRE---ETI---EWLRDLDIHETRLSELLNIPADLQ 598
                  ...|.:.|....|:.|   |::   ||::|......:....|.:|.:|:
E. coli   384 ------PVADKEFGHRPVAVMEYDHESVDLSEWVKDKLARFQQPVRWLTLPPELK 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	122/561 (22%)
menE	NP_416763.1	PRK09029	1..451	CDD:236363	127/575 (22%)