Protein Alignment hll and ACSBG2

DIOPT Version :9

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001276106.1
• Gene: ACSBG2 / 81616
• HGNCID: 24174
• Length: 666
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 252/688 - (36%)
• Similarity: 393/688 - (57%)
• Gaps: 48/688 - (6%)

  Fly     1 MNDLKPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGND 65
            ||..:......:|.....|.|||.:.....:|  |.||||||:||..::...|||.    .....
Human    18 MNKTEVTPRLWTTCRDGEVLLRLSKHGPGHET--PMTIPEFFRESVNRFGTYPALA----SKNGK 76

  Fly    66 GWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSA 130
            .|..|.|.:|.|...:||..|:.:|:|....||||.||..|||....||:.||.:..|:|.:|||
Human    77 KWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSA 141

  Fly   131 EAVHHVLATGESSVCVVDDAQQMAKLRAI-KERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQE 194
            |...:|:...:.::.:|::.||:.|:.:| :..|..|||:||...|.:    .....:||....|
Human   142 EVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMK----KNNNLYSWDDFME 202

  Fly   195 --QTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQV- 256
              ::......|:::  ||: :||:||:||:||||.|:||.|||||||:   |..|.|..:|.::
Human   203 LGRSIPDTQLEQVI--ESQ-KANQCAVLIYTSGTTGIPKGVMLSHDNI---TWIAGAVTKDFKLT 261

  Fly   257 -GKESFVSYLPLSHVAAQIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEK 320
             ..|:.||||||||:|||:.|:::.:.......||..|||||||:.|.::.:||...|||:::||
Human   262 DKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEK 326

  Fly   321 LQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGK--SPSIYGNAKYWLACRVVKPIREMIG 383
            :.|.:....||:....:.....||....:..:..|.||  :|..|..||    ..|...::..:|
Human   327 IHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAK----TLVFSKVKTSLG 387

  Fly   384 VDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMSETSGAITL-NVDISNLYSAGQACEGVTLK 447
            :|:|..|.:|.||.::|..:|||.|||.:||.||:||:||..|: |.:...|.|.|:...|....
Human   388 LDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNM 452

  Fly   448 IHEPDCNGQGEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKGNLIISGRLKELII 512
            :.:.:.:|.|||.:.||.:|||||....:|.|.:.::|||||||||.:|..|.|.::|.:||::|
Human   453 LFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILI 517

  Fly   513 TAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWL 577
            ||||||:||:.:|.|:||::|.:||.:|:||..|:|::||:||.:.:..:|.|||.|..|.|.:.
Human   518 TAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFC 582

  Fly   578 RDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQK 642
            |.|....:.::|::.                    ...|.:.:||::||...|:.|::|||:::|
Human   583 RGLGSQASTVTEIVK--------------------QQDPLVYKAIQQGINAVNQEAMNNAQRIEK 627

  Fly   643 FALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            :.::..:||:..|||||.:|::|:.|..||.|.|:.:|
Human   628 WVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	231/625 (37%)
ACSBG2	NP_001276106.1	ACSBG_like	73..665	CDD:341256	231/625 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	384	1.000	Domainoid score	I818
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1198
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58630
OrthoDB	1	1.010	-	-		D218492at33208
OrthoFinder	1	1.000	-	-		FOG0003543
OrthoInspector	1	1.000	-	-		mtm8537
orthoMCL	1	0.900	-	-		OOG6_101481
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6795
SonicParanoid	1	1.000	-	-		X2420
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870