Protein Alignment hll and slc27a6

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001070854.2
• Gene: slc27a6 / 568835
• ZFINID: ZDB-GENE-060825-27
• Length: 618
• Species: Danio rerio
• Alignment Length: 693
• Identity: 136/693 - (19%)
• Similarity: 239/693 - (34%)
• Gaps: 236/693 - (34%)

  Fly    37 TIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILA 101
            ||.:.|.:..:::.:.|.:::|        ..|.|:|:.:.|..:.| .|....|::..:|.:|.
Zfish    54 TIVDRFVQQAQRFPEKPFVIFE--------GVTYTYGDLEARSNRVA-RLFQDTVKKGDTVALLM 109

  Fly   102 FNCPEWFFAEFGALRAGAVVAGVYPS-NSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPR 165
            .|.|::....||..:.|..:|.:..: .|...:|.....|...:.|..|.     |..:::.||.
Zfish   110 NNEPDFISVWFGFCKLGCALAFLNTNIKSRSLLHCFNCCGAKQLVVGADL-----LDNLEDILPS 169

  Fly   166 LK----AVIQL-HGPFEAFVDHEPGYFS-WQKLQEQTFSSELKEELLARESRIRANEC----AML 220
            |:    .|..| ||      :..||..| ..|:::.:     :|.:.|:.   |:..|    .:.
Zfish   170 LQEDNITVWSLGHG------NSHPGVHSLLDKIEKSS-----QEPIAAKR---RSISCLKTPTLY 220

  Fly   221 IFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQV--------GKESFVSY--LPLSHVAAQIF 275
            ||||||.|:|||.:::             |:|.::.        |.|..|.|  |||.|.||.:
Zfish   221 IFTSGTTGLPKAAVIT-------------HLQSLKAAGGFWAYGGTEKDVIYTPLPLYHSAASL- 271

  Fly   276 DVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLL 340
               :|:.              ||:
Zfish   272 ---VGIG--------------GTI----------------------------------------- 278

  Fly   341 ARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVK-PIREMIGVDNCRVFFTGGAPTSEELKQF 404
                    |...|.:..|.   :..:::|..||... .|.:.|| :.||.........:|:..:.
Zfish   279 --------ELGATCILKKK---FSASQFWNDCRKYNVTIFQYIG-ELCRYLCNQPMGENEKDHKV 331

  Fly   405 FLGL-----------------DIALGECYGMSETSGAITLNVDISNLYSAGQA-----------C 441
            .:|:                 :|.:.|.||  .|.|.:.....|..:.:.|::           .
Zfish   332 HMGVGNGLRQDVWREFLQRFGEIRMCEIYG--STEGNLCFMNHIGKIGAVGRSNFFYKLIFKYDL 394

  Fly   442 EGVTLKIHEP--DCNGQGEILMRG-----------RLVFMGYLGLPDKTEET------VKEDGWL 487
            ....|...||  |.||..:.:.:|           :..|.||.|....||:.      ||.|.:.
Zfish   395 VKYDLLRDEPVRDHNGFCQRVQKGETGLLLSKICSQSPFFGYAGSKQLTEKKILRDVFVKGDAYF 459

  Fly   488 HSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKK----ELPCVSNVLLIGDHRKYL 548
            ::|||...|....:....|:.: .....|||:....:.|::..    :...|..|.:.|:..:..
Zfish   460 NTGDLMAEDENNFISFKDRVGD-TFRWKGENVATTEVTEILGLVDFIQEASVYGVQVPGNEGRAG 523

  Fly   549 TVLLSLKTKC--DAKTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLE 611
            ...:.::.:|  |.|.              |.||.:.|              ||:
Zfish   524 MAAVIVRPECTFDGKK--------------LFDLVVRE--------------LPS---------- 550

  Fly   612 ITAKPKLLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVAT 654
             .|:| |...::|.|:..:.:      |.|||.|:...|:.:|
Zfish   551 -YARP-LFIRLQESIETTSTF------KHQKFGLVESGFNPST 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	131/668 (20%)
slc27a6	NP_001070854.2	Adenylate forming domain, Class I superfamily	74..608	CDD:473059	132/673 (20%)