DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and acsl3a

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001038593.1	Gene:	acsl3a / 567157	ZFINID:	ZDB-GENE-050420-181	Length:	713	Species:	Danio rerio

Alignment Length:	753	Identity:	179/753 - (23%)
Similarity:	288/753 - (38%)	Gaps:	177/753 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PATSYRSTS--------LHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPA-----LVW 57
            ||..||..:        ||..:                .|:.:.|:.|...:.:...     |:.
Zfish    57 PAGPYRDVAALKGLEMCLHPGI----------------NTLDQVFQSSVSHFPNSDCLGTRELLS 105

  Fly    58 ETPGSGNDG--WTTLTFGEYQ--------ERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEF 112
            |...:..||  :..:..|||:        :.|......|.::|.:...::.|......||..|..
Zfish   106 EEDETQEDGKVFKKVILGEYRWMSYEQVFKEVNAFGSGLAALGQKPMKNIAIFCETRAEWIIAAQ 170

  Fly   113 GALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFE 177
            ........:..:|.:....|:.|.|...|.|..:........||::|...:|||..||.:.....
Zfish   171 ACFMYNFPLVTLYSTLGGPAIAHGLNEAEVSHIITSKDLLETKLKSIFIEVPRLCHVIVVDDKLS 235

  Fly   178 AFVDHEPGYFSWQKLQEQTFSSELKEELLARESRIR-------ANECAMLIFTSGTVGMPKAVML 235
            ...::..|.        ...|....:||.||.....       :::.|::::|||:.|:||.||:
Zfish   236 TSSEYPRGI--------SIHSMASVKELGARPENASKPKNPPCSSDVAVIMYTSGSTGVPKGVMI 292

  Fly   236 SHDNLVFDTKSAAAHMQDIQVGKESFVSYLPLSHVAAQIFDVFLGLSHAGC-VTFADKDAL--KG 297
            ||.|::... :...|.....|..::::.||||:|| .::....:.|:| || :.::....|  :.
Zfish   293 SHSNIISGI-TGMTHRIPKLVEDDTYIGYLPLAHV-LELSAEMVCLAH-GCRIGYSSPQTLSDQS 354

  Fly   298 TLIKTFRKA-----RPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAG 357
            |.||...:.     |||.|..||.:.:::.:.::....:...:.|.|...|.....|.   |..|
Zfish   355 TKIKKGSRGDISVLRPTLMAAVPEIMDRIYKNVMLRVEQMSGFQRTLFLLAYNYKMEQ---LAMG 416

  Fly   358 KSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGECYGM 418
            .|..:....       |.:.:|.::| ...||..:||||.|...::|   ::|.    :|:.||:
Zfish   417 YSTPLCDKL-------VFRKVRALLG-GRLRVLLSGGAPLSAATQRF---MNICFCCPVGQGYGL 470

  Fly   419 SETSGAITLNVDISNL--YSAGQ------ACEGVTLK------IHEPD--CNGQGEILMRGRLVF 467
            :||.||.|    ||:|  ||.|:      .|| :.||      .|..|  | .:||||:.|..:.
Zfish   471 TETCGAGT----ISHLWDYSTGRVGAPLVCCE-LQLKDWIEGGYHSTDLPC-PRGEILVGGPSIT 529

  Fly   468 MGYLGLPDKTEETV----KEDGWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELI 528
            |||.....||.|..    |...|..:||:|.|...|.|.|..|.|:|:....||.:....:|..:
Zfish   530 MGYYKNTHKTSEDFFVDKKGQRWFCTGDIGEIHGDGCLKIIDRKKDLVKLQAGEYVSLGKVEAAL 594

  Fly   529 KKELPCVSNV---------LLIG---DHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLD 581
             |..|.|.|:         .:||   .::|.|..|...|.                    :|.|
Zfish   595 -KNCPLVDNICAYANSDESYVIGFVVPNQKQLLALAERKR--------------------VRGL- 637

  Fly   582 IHETRLSELLNIP----ADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQK 642
                 ..||.|.|    |.|.:..: |||.|.||....|:                        |
Zfish   638 -----WEELCNNPVIEEAVLTVLTE-AALTAQLERFEIPR------------------------K 672

  Fly   643 FALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            ..|....::..||.:..:.|::|..:...|...|||:|
Zfish   673 IRLSVEPWTPDTGLVTDSFKLKRKELKTHYQNDIERMY 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	167/682 (24%)
acsl3a	NP_001038593.1	PLN02387	77..710	CDD:215217	172/731 (24%)
acsl3a	NP_001038593.1	LC-FACS_euk	123..710	CDD:213293	165/669 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810