DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and acsl3b

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001139404.1	Gene:	acsl3b / 559656	ZFINID:	ZDB-GENE-030131-492	Length:	711	Species:	Danio rerio

Alignment Length:	750	Identity:	179/750 - (23%)
Similarity:	306/750 - (40%)	Gaps:	171/750 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PATSYRSTS--------LHDAVKLRLDEPSSFSQTVPPQTIPEFFKESC----EKYSDLPAL--- 55
            ||..||:.:        ||:.|. .||:...::       :..|.:..|    |..|:...:
Zfish    55 PAGPYRAVNSQLKLASLLHEGVD-TLDKVFEYA-------VVHFPERDCLGTRELLSEEDEIQPN 111

  Fly    56 --VWETPGSGNDGWTTLTFGEYQERVEQAALM---LLSVGVEERSSVGILAFNCPEWFFAEFGAL 115
              |::....|:..|.:     ||:....|...   |.::|.:...::.|......||..|.....
Zfish   112 GKVFKKVILGDYNWLS-----YQDTFHLAQRFGSGLAALGQKPLCNIAIFCETRAEWVIAAQACF 171

  Fly   116 RAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFV 180
            .....:..:|.:....|:.|.|...|.:..|.......::|:||...:||||.:|        .|
Zfish   172 MYNFPLVTLYSTLGGSAIAHGLNETEVTHIVTSKDLLQSRLKAILLEVPRLKHII--------VV 228

  Fly   181 DHEPGYFSWQKLQE----------QTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVML 235
            |.:|  .||..|..          |...|:.:..:::|...: .::.|::::|||:.|:||.||:
Zfish   229 DTKP--TSWPDLPRGIMVHNMAAVQELGSKPENIMVSRRQPV-PSDIAVIMYTSGSTGIPKGVMI 290

  Fly   236 SHDNLVFDTKSAAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFADKDA- 294
            ||.|::......|..:.::. ..::::.||||:||   :|::..|..|  :.::...|.||:.:
Zfish   291 SHSNIIAGITGMAERIPNLD-ENDTYIGYLPLAHVLELSAELVCVSHGCRIGYSSPQTLADQSSK 354

  Fly   295 -LKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARA----RAAVAEHQTTL 354
             .||:...| ...:||.|..||.:.:::.:.::....:.....:.|...|    ...:::..||.
Zfish   355 IKKGSKGDT-SVLKPTLMAAVPEIMDRIYKNVMTKVEEMSSVQKTLFVLAYNYKMEQISKGYTTP 418

  Fly   355 MAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGEC 415
            :..:              .|.:.:|.::| .|.||..:||||.|...::|   ::|.    :|:.
Zfish   419 LCDR--------------LVFRKVRSLLG-GNTRVLLSGGAPLSAATQRF---MNICFCCPVGQG 465

  Fly   416 YGMSETSGAITLNVDISNLYSAGQ-----ACEGVTLKIHE---------PDCNGQGEILMRGRLV 466
            ||::||.||.|:: ::|: ||.|:     .|..:.||..|         |  |.:||||:.|..|
Zfish   466 YGLTETCGAGTIS-EMSD-YSTGRVGAPLVCSEIMLKDWEEGGYFSTDKP--NPRGEILIGGPNV 526

  Fly   467 FMGYLGLPDKTEETVKED----GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEEL 527
            .|||.....|..|...||    .|..:||:|...|.|.|.|..|.|:|:....||.:....:|.:
Zfish   527 TMGYYKNEQKNREDFFEDKNGQRWFCTGDIGEFHPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAV 591

  Fly   528 IKKELPCVSNV---------LLIG---DHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDL 580
            : |..|.:.|:         .:||   .::|.||.|...|       ||        ...| .::
Zfish   592 L-KNCPLIDNICAYANSDESYVIGFVVPNQKQLTALAGQK-------GI--------RGSW-EEI 639

  Fly   581 DIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFAL 645
            ..|.....|:|.|..|       ||::..||....||                        |..|
Zfish   640 CNHAEMEKEVLRIITD-------AAISGKLERFEIPK------------------------KICL 673

  Fly   646 IAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            .|..::..||.:....|::|..:...|...|||:|
Zfish   674 SAEPWTPETGLVTDAFKLKRKELKTHYQDDIERMY 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	164/675 (24%)
acsl3b	NP_001139404.1	PLN02387	43..708	CDD:215217	178/748 (24%)
acsl3b	NP_001139404.1	LC-FACS_euk	121..708	CDD:213293	164/674 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810