DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and Acsl

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	169/742 - (22%)
Similarity:	288/742 - (38%)	Gaps:	174/742 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DEPSSFSQTVPPQ------------TIPEFFKESCEKYSDLPAL-----------------VWET 59
            |...::..|.||:            |:.:.|....:.|:....|                 |::.
  Fly    74 DNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKK 138

  Fly    60 PGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGV 124
            ...|:..|.|.|  |.:.........|..:|.:.|.::.|.|....||..|..|..:....:..|
  Fly   139 YNLGDYKWKTFT--EAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTV 201

  Fly   125 YPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSW 189
            |.:...:.|.|.:...|.:. |:.....:.|.:.:.::.|.:|.:|.:....
  Fly   202 YATLGDDGVAHCITETEVTT-VITSHDLLPKFKTLLDKCPLVKTIIYIEDQL------------- 252

  Fly   190 QKLQEQTFSSELK----EELL--ARESRI-----RANECAMLIFTSGTVGMPKAVMLSHDNLVFD 243
            ||.:...|...:|    .:::  .::|:.     :.::.|::::|||:.|.||.|:|||.|.:..
  Fly   253 QKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIAT 317

  Fly   244 TKS----AAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFAD-----KDA 294
            .|.    ...:..|:.:|      :|||:||   .|:...:..|  :.::..:|..|     |..
  Fly   318 MKGFVDMVPIYPDDVLIG------FLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRG 376

  Fly   295 LKG--TLIKTFRKARPTKMFGVP----RVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTT 353
            .||  |::|      ||.|..||    |:.:.:.:::.:..|..:...:.|.......|.....|
  Fly   377 CKGDATVLK------PTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKT 435

  Fly   354 LMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAP----TSEELKQFFLGLDIALGE 414
            .:..|              .|.|.:.:::| ...|:..:||||    |.|::|. .|.|::..|
  Fly   436 PLIDK--------------LVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKT-CLCLELIQG- 483

  Fly   415 CYGMSE-TSGAITLNV-DISNLYSAG--QAC--------EG---VTLKIHEPDCNGQGEILMRGR 464
             ||::| ||||..::. |::...:.|  ..|        ||   ||.|.:.     |||:|:.|.
  Fly   484 -YGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYP-----QGEVLIGGE 542

  Fly   465 LVFMGYLGLPDKT-EETVKEDG--WLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEE 526
            .|..||..||.|| |:..:|||  |..:||:|.|...|.|.|..|.|:|:....||.:....:|.
  Fly   543 CVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVES 607

  Fly   527 LIKKELPC--VSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSE 589
            .:|   .|  :.|:.:.||..|..||.|.:..:...:.......|.:::.|             |
  Fly   608 ELK---TCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFE-------------E 656

  Fly   590 LLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIK-RANKYAISNAQKVQKFALIAHEFSVA 653
            |.:.|                 |..|..|.|..|...| :..||.:..|     ..|....:|..
  Fly   657 LCSSP-----------------IIEKAILKEIAEHARKCKLQKYEVPAA-----ITLCKEVWSPD 699

  Fly   654 TGELGPTLKIRRNIVHAKYAKVIERLY 680
            .|.:....|::|..:..:|...|.|:|
  Fly   700 MGLVTAAFKLKRKDIQDRYQHDINRMY 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	159/673 (24%)
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	165/721 (23%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	159/672 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22484at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750