Protein Alignment hll and Acsl

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 169/742 - (22%)
• Similarity: 288/742 - (38%)
• Gaps: 174/742 - (23%)

  Fly    24 DEPSSFSQTVPPQ------------TIPEFFKESCEKYSDLPAL-----------------VWET 59
            |...::..|.||:            |:.:.|....:.|:....|                 |::.
  Fly    74 DNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKK 138

  Fly    60 PGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGV 124
            ...|:..|.|.|  |.:.........|..:|.:.|.::.|.|....||..|..|..:....:..|
  Fly   139 YNLGDYKWKTFT--EAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTV 201

  Fly   125 YPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSW 189
            |.:...:.|.|.:...|.:. |:.....:.|.:.:.::.|.:|.:|.:....
  Fly   202 YATLGDDGVAHCITETEVTT-VITSHDLLPKFKTLLDKCPLVKTIIYIEDQL------------- 252

  Fly   190 QKLQEQTFSSELK----EELL--ARESRI-----RANECAMLIFTSGTVGMPKAVMLSHDNLVFD 243
            ||.:...|...:|    .:::  .::|:.     :.::.|::::|||:.|.||.|:|||.|.:..
  Fly   253 QKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIAT 317

  Fly   244 TKS----AAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFAD-----KDA 294
            .|.    ...:..|:.:|      :|||:||   .|:...:..|  :.::..:|..|     |..
  Fly   318 MKGFVDMVPIYPDDVLIG------FLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRG 376

  Fly   295 LKG--TLIKTFRKARPTKMFGVP----RVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTT 353
            .||  |::|      ||.|..||    |:.:.:.:::.:..|..:...:.|.......|.....|
  Fly   377 CKGDATVLK------PTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKT 435

  Fly   354 LMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAP----TSEELKQFFLGLDIALGE 414
            .:..|              .|.|.:.:::| ...|:..:||||    |.|::|. .|.|::..|
  Fly   436 PLIDK--------------LVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKT-CLCLELIQG- 483

  Fly   415 CYGMSE-TSGAITLNV-DISNLYSAG--QAC--------EG---VTLKIHEPDCNGQGEILMRGR 464
             ||::| ||||..::. |::...:.|  ..|        ||   ||.|.:.     |||:|:.|.
  Fly   484 -YGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYP-----QGEVLIGGE 542

  Fly   465 LVFMGYLGLPDKT-EETVKEDG--WLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEE 526
            .|..||..||.|| |:..:|||  |..:||:|.|...|.|.|..|.|:|:....||.:....:|.
  Fly   543 CVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVES 607

  Fly   527 LIKKELPC--VSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSE 589
            .:|   .|  :.|:.:.||..|..||.|.:..:...:.......|.:::.|             |
  Fly   608 ELK---TCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFE-------------E 656

  Fly   590 LLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIK-RANKYAISNAQKVQKFALIAHEFSVA 653
            |.:.|                 |..|..|.|..|...| :..||.:..|     ..|....:|..
  Fly   657 LCSSP-----------------IIEKAILKEIAEHARKCKLQKYEVPAA-----ITLCKEVWSPD 699

  Fly   654 TGELGPTLKIRRNIVHAKYAKVIERLY 680
            .|.:....|::|..:..:|...|.|:|
  Fly   700 MGLVTAAFKLKRKDIQDRYQHDINRMY 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	159/673 (24%)
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	156/660 (24%)