Protein Alignment hll and acsl5

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001004599.2
• Gene: acsl5 / 447860
• ZFINID: ZDB-GENE-040912-169
• Length: 681
• Species: Danio rerio
• Alignment Length: 676
• Identity: 181/676 - (26%)
• Similarity: 287/676 - (42%)
• Gaps: 103/676 - (15%)

  Fly    36 QTIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVE--ERSSVG 98
            :|:.|.|:.......:.|.|.:...|.... |  |.:.:..:|.|.....|:..|.:  :.:.:|
Zfish    75 KTLYEVFQRGLRVSGNGPCLGFRKKGQPYQ-W--LKYKQVSDRAEFLGSGLIHRGQKPSQDTFIG 136

  Fly    99 ILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKL--RAIKE 161
            |.|.|.|||..||........|...:|.:...||:..::.....|..:.|...:...|  .:.|:
Zfish   137 IFAQNRPEWIIAELACYTYSMVAVPLYDTLGPEALVFIINRANISTVICDKKDKAETLLDNSEKK 201

  Fly   162 RLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKE-ELLARESRIR-----ANECAML 220
            ..|.||.:|.:.....|..:.      ..|:.....|  ||: |.|.:.:..|     ..:.:::
Zfish   202 LTPLLKTIILMDSYDSALTER------GSKIGLDVLS--LKDVEALGKNNHHRPVPPKPEDLSII 258

  Fly   221 IFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQD--IQVGKESFVSYLPLSHVAAQIFD-VFLGLS 282
            .|||||.|.||..||:|:|:|.|........:.  :.|..:..:|:|||:|:..::.. |..|:
Zfish   259 CFTSGTTGDPKGAMLTHENVVADAAGVVRTFESVFVPVPSDVSISFLPLAHMFERVVQTVLYGV- 322

  Fly   283 HAGCVTFADKDALKGTLIKTFRKA-RPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAA 346
             .|.|.|...|.   .|:....|| :||....|||:..::.:: |.:.||. |:.:.||   ..|
Zfish   323 -GGRVGFFQGDI---RLLPDDMKALQPTVFPVVPRLLNRVYDK-VQSGAKT-PFKKWLL---NFA 378

  Fly   347 VAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFF---LGL 408
            :.:....:..|    |..|...|... :...::|.:| ...||..||.||.|..:..|.   ||.
Zfish   379 IEKKCAEVKQG----IIRNDSMWDKL-IFHKVQESLG-GRVRVMVTGAAPISPSVLTFLRACLGC 437

  Fly   409 DIALGECYGMSETSGAITLNVDISNLYSAGQA-----CEGVTL-KIHEPD---CNGQGEILMRGR 464
            .|.  |.||.:|.:.|.:..  |...:..|..     |..:.| .:.|.|   .||:|||.::|.
Zfish   438 QIF--EAYGQTECTAACSFT--IPGDWKTGHVGAPIPCNTIKLVDVEEMDYFASNGEGEICVKGT 498

  Fly   465 LVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIK 529
            .||.||||.|:||.|.:.:|||||:||:|...|.|.|.|..|.|.:...|.||.|.|..||.:..
Zfish   499 NVFRGYLGDPEKTAEALDKDGWLHTGDIGKWLPSGVLKIIDRKKNIFKLAQGEYIAPEKIENVYI 563

  Fly   530 KELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSELLNIP 594
            :..| |:.|.:.|:         ||::...|                              :.:|
Zfish   564 RSAP-VAQVFVHGE---------SLQSSLVA------------------------------IVVP 588

  Fly   595 ADLQLPN--DTAALAATL-EITAKPKLLEAIEEGIKRANKYA-ISNAQKVQKFALIAHEFSVATG 655
            ....||.  :...|..:| |:....:|.:||...:.:..:.| :.:.::|:...|....|::..|
Zfish   589 DPEVLPGFAEKLGLKGSLEELCRNQELKKAIISDLNKLGREAGLKSFEQVKDLYLHPDMFTIENG 653

  Fly   656 ELGPTLKIRRNIVHAKYAKV-IERLY 680
            .|.||||.:|..: .||.:| ||.||
Zfish   654 LLTPTLKAKRADL-TKYFRVQIESLY 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	173/648 (27%)
acsl5	NP_001004599.2	LC-FACS_euk	101..679	CDD:341250	175/650 (27%)