DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and acsl4a

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_956943.1	Gene:	acsl4a / 393622	ZFINID:	ZDB-GENE-040426-1565	Length:	706	Species:	Danio rerio

Alignment Length:	757	Identity:	173/757 - (22%)
Similarity:	308/757 - (40%)	Gaps:	184/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGNDG--- 66
            :|...||||...::: :.:|.|..       .|:.:.|..:.|::..|..|......||::.
Zfish    50 QPDGPYRSTDRFESL-VTVDFPGK-------DTLDKLFDYAVERFGKLDCLGTREVLSGDNETQP 106

  Fly    67 ----WTTLTFGEYQER--------VEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGA 119
                :..|..|||:.:        |......|.::|.:.:|::.|......||........|...
Zfish   107 NGKVFKKLILGEYKWKSYEELDIEVSHFGSGLAALGQQPKSTIAIFCETRAEWMITAQACFRRNF 171

  Fly   120 VVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQM--AKLRAIKERLPRLKAVIQLHGPFEAFVDH 182
            .:...|.:...:||.:.|  .||.|..:..:.::  .||:::..::|.||.:|        :||.
Zfish   172 PLVTFYATLGEDAVAYGL--NESGVTHLVTSIELLETKLKSVLLQIPNLKHII--------YVDS 226

  Fly   183 EPGYFSWQKLQEQTFSSELKEELLARESRIR-------ANECAMLIFTSGTVGMPKAVMLSHDNL 240
            :....:......|..|....|||.|:...:.       .::.|::::|||:.|.||.||:.|.||
Zfish   227 KSMNTAGFPQGIQIHSMHSVEELGAKPENLNRPIVKPVPSDLAVIMYTSGSTGRPKGVMIIHSNL 291

  Fly   241 VFDTKSAAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFADKDALKGTLI 300
            :.........:..:. .|:::::||||:||   .|:|..|..|  :.::...|.:|    :.|.|
Zfish   292 IGGMAGQCERIPGLG-PKDTYIAYLPLAHVLEMTAEISCVTYGCRIGYSSPQTLSD----QSTKI 351

  Fly   301 KTFRKA-----RPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSP 360
            |...|.     :|:.|..||.:.:::.:.:::...:.....|.|...|.....|.   :..|...
Zfish   352 KKGSKGDCSVLKPSLMAAVPEIMDRINKNVMSKVQEMSCVQRTLFKPAYDYKLEQ---IKKGYDA 413

  Fly   361 SIYGNAKYWLACRVV-KPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGECYGMSE 420
            .:         |.:: |.:|.::| .|.|:..:||||.|...::|   ::|.    :|:.||::|
Zfish   414 PL---------CNILFKKVRALLG-GNVRMMLSGGAPLSPATQRF---MNICFCCPVGQGYGLTE 465

  Fly   421 TSGAITLNVDISNLYSAGQA--------------CEGVTLKIHEPDCNGQGEILMRGRLVFMGYL 471
            |.||.|: .:::: ||.|:.              .||...|..:|  :.:||||:.|..|.|||.
Zfish   466 TCGAGTI-TEVAD-YSTGRVGAPLICCEVKLKDWAEGGYTKRDKP--HPRGEILIGGPNVTMGYY 526

  Fly   472 GLPDKTEETVKED--------GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELI 528
                :||....:|        .|..:||:|.:...|.|.|..|.|:|:....||.:....:|..:
Zfish   527 ----RTEGCNNDDFFVDQNGQRWFCTGDIGEMHADGCLQIVDRKKDLVKLQAGEYVSLGKVESAL 587

  Fly   529 KKELPC--VSNVL------------LIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRD 579
            |.   |  |.|:.            .|..::|.||.|.:.|       ||      |.|.|
Zfish   588 KN---CSFVDNICAYANSDQNYVISFIVPNQKKLTALANQK-------GI------EGTWE---- 632

  Fly   580 LDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFA 644
                     |:.|.|                  ..:.::|..|:|         ::|:.|:|:|.
Zfish   633 ---------EICNHP------------------VMEREVLREIKE---------VANSIKLQRFE 661

  Fly   645 L--IAH----EFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            :  :.|    .::..||.:....|::|..:...|...|||:|
Zfish   662 IPVMVHLSPEPWTPETGLVTDAFKLKRKELKNHYLNDIERMY 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	160/698 (23%)
acsl4a	NP_956943.1	PLN02387	60..703	CDD:215217	167/745 (22%)
acsl4a	NP_956943.1	LC-FACS_euk	117..703	CDD:213293	157/680 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900