Protein Alignment hll and acsl4a

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_956943.1
• Gene: acsl4a / 393622
• ZFINID: ZDB-GENE-040426-1565
• Length: 706
• Species: Danio rerio
• Alignment Length: 757
• Identity: 173/757 - (22%)
• Similarity: 308/757 - (40%)
• Gaps: 184/757 - (24%)

  Fly     5 KPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGNDG--- 66
            :|...||||...::: :.:|.|..       .|:.:.|..:.|::..|..|......||::.
Zfish    50 QPDGPYRSTDRFESL-VTVDFPGK-------DTLDKLFDYAVERFGKLDCLGTREVLSGDNETQP 106

  Fly    67 ----WTTLTFGEYQER--------VEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGA 119
                :..|..|||:.:        |......|.::|.:.:|::.|......||........|...
Zfish   107 NGKVFKKLILGEYKWKSYEELDIEVSHFGSGLAALGQQPKSTIAIFCETRAEWMITAQACFRRNF 171

  Fly   120 VVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQM--AKLRAIKERLPRLKAVIQLHGPFEAFVDH 182
            .:...|.:...:||.:.|  .||.|..:..:.::  .||:::..::|.||.:|        :||.
Zfish   172 PLVTFYATLGEDAVAYGL--NESGVTHLVTSIELLETKLKSVLLQIPNLKHII--------YVDS 226

  Fly   183 EPGYFSWQKLQEQTFSSELKEELLARESRIR-------ANECAMLIFTSGTVGMPKAVMLSHDNL 240
            :....:......|..|....|||.|:...:.       .::.|::::|||:.|.||.||:.|.||
Zfish   227 KSMNTAGFPQGIQIHSMHSVEELGAKPENLNRPIVKPVPSDLAVIMYTSGSTGRPKGVMIIHSNL 291

  Fly   241 VFDTKSAAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFADKDALKGTLI 300
            :.........:..:. .|:::::||||:||   .|:|..|..|  :.::...|.:|    :.|.|
Zfish   292 IGGMAGQCERIPGLG-PKDTYIAYLPLAHVLEMTAEISCVTYGCRIGYSSPQTLSD----QSTKI 351

  Fly   301 KTFRKA-----RPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSP 360
            |...|.     :|:.|..||.:.:::.:.:::...:.....|.|...|.....|.   :..|...
Zfish   352 KKGSKGDCSVLKPSLMAAVPEIMDRINKNVMSKVQEMSCVQRTLFKPAYDYKLEQ---IKKGYDA 413

  Fly   361 SIYGNAKYWLACRVV-KPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGECYGMSE 420
            .:         |.:: |.:|.::| .|.|:..:||||.|...::|   ::|.    :|:.||::|
Zfish   414 PL---------CNILFKKVRALLG-GNVRMMLSGGAPLSPATQRF---MNICFCCPVGQGYGLTE 465

  Fly   421 TSGAITLNVDISNLYSAGQA--------------CEGVTLKIHEPDCNGQGEILMRGRLVFMGYL 471
            |.||.|: .:::: ||.|:.              .||...|..:|  :.:||||:.|..|.|||.
Zfish   466 TCGAGTI-TEVAD-YSTGRVGAPLICCEVKLKDWAEGGYTKRDKP--HPRGEILIGGPNVTMGYY 526

  Fly   472 GLPDKTEETVKED--------GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELI 528
                :||....:|        .|..:||:|.:...|.|.|..|.|:|:....||.:....:|..:
Zfish   527 ----RTEGCNNDDFFVDQNGQRWFCTGDIGEMHADGCLQIVDRKKDLVKLQAGEYVSLGKVESAL 587

  Fly   529 KKELPC--VSNVL------------LIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRD 579
            |.   |  |.|:.            .|..::|.||.|.:.|       ||      |.|.|
Zfish   588 KN---CSFVDNICAYANSDQNYVISFIVPNQKKLTALANQK-------GI------EGTWE---- 632

  Fly   580 LDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFA 644
                     |:.|.|                  ..:.::|..|:|         ::|:.|:|:|.
Zfish   633 ---------EICNHP------------------VMEREVLREIKE---------VANSIKLQRFE 661

  Fly   645 L--IAH----EFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            :  :.|    .::..||.:....|::|..:...|...|||:|
Zfish   662 IPVMVHLSPEPWTPETGLVTDAFKLKRKELKNHYLNDIERMY 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	160/698 (23%)
acsl4a	NP_956943.1	LC_FACS_euk1	117..691	CDD:341294	153/668 (23%)
		PRK04813	<230..>292	CDD:235313	17/61 (28%)