DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hll and acsl4b

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001093209.1	Gene:	acsl4b / 334561	ZFINID:	ZDB-GENE-030131-6493	Length:	671	Species:	Danio rerio

Alignment Length:	748	Identity:	182/748 - (24%)
Similarity:	295/748 - (39%)	Gaps:	165/748 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPATSYRSTSLHDAV------------KLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVW 57
            :|...||:....||:            ||.:....||:| .|.....|...|..||..:  ..::
Zfish    14 RPEGPYRAVESIDALVTQGFEGVDTLDKLFVHAVKSFNQ-APCLGTREVLSEEEEKQPN--GKIF 75

  Fly    58 ETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVA 122
            :....||..|  :::....:.||.....|.::|.:.|.::.|......||..|.....|....:.
Zfish    76 KKLVLGNYSW--MSYEAVDQAVESFGSGLAALGQKPRQTIAIFCETRAEWMIAAQACFRRNYPLV 138

  Fly   123 GVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYF 187
            .:|.:...:||.:.|....::..:.......:||:.:...:..|:.||.: |..|......|...
Zfish   139 TLYATLGEDAVAYGLNQCGATHLITSTELLQSKLKNVLFAVSGLQHVIYV-GSGEVHQADYPQSL 202

  Fly   188 SWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQ 252
            ....:||.|......|.|.....|..|::.|::::|||:.|.||.|.:.|.||:   ...|...|
Zfish   203 IIHSMQEVTELGAKPENLSVEYERPSASDLAVVMYTSGSTGNPKGVKMQHSNLI---AGMAGQCQ 264

  Fly   253 DIQ-VG-KESFVSYLPLSHVAAQIFDVFLGLSHAGC-VTFADKDAL--KGTLIKTFRKA-----R 307
            .|. :| :::.||||||:||.....::.. ||| || :.::....|  :.:.||...|.     :
Zfish   265 RIPGLGSQDTIVSYLPLAHVLELTAEISC-LSH-GCRLGYSSPHTLTDQSSKIKKGSKGDCSVLK 327

  Fly   308 PTKMFGVPRVFE--------KLQERLV--------AAEAKARPYSRLLLARARAAVAEHQTTLMA 356
            ||.:..||.:.:        ||||..|        ..:.|.:..|:                  .
Zfish   328 PTLIAAVPEIMDRICKNVNGKLQEMSVIKRTLFKLGFDYKLQQVSK------------------G 374

  Fly   357 GKSPSIYGNAKYWLACRVV--KPIREMIGVDNC-RVFFTGGAPTSEELKQFF--LGLDIALGECY 416
            ..||          .|.::  |.:..::|  .| |...:||||.|...::|.  ....||:|  |
Zfish   375 ADSP----------MCDMLFFKQVNVLLG--GCVRRMLSGGAPLSASTQRFMNVCFCPIAVG--Y 425

  Fly   417 GMSETSGAITLNVDISNLYSAGQA-----CEGVTLK-------IHEPDCNGQGEILMRGRLVFMG 469
            |::||.||.|:: |.|: ||.|:.     |..:.|:       ..:...:.:||||:.|..|.||
Zfish   426 GLTETCGAGTIS-DSSD-YSTGRVGAPLICSEIKLRDWPEGGYTSQDKPHPRGEILIGGPNVAMG 488

  Fly   470 YLGLPDKTEET---VKEDG--WLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIK 529
            |.|...:.:..   |.|.|  |..:||:|.:.|.|.|.|..|.|:|:....||.:....:|..:|
Zfish   489 YYGSEGEGQNDNFWVDEAGQRWFSTGDIGEVHPDGCLEIVDRKKDLVKLQAGEYVSLGKVEAAMK 553

  Fly   530 KELPCVSNVLL------------IGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDI 582
            .. |.:.|:.:            :..::|.||.|..       |:||  |.      || .|:..
Zfish   554 NS-PLIDNICVYASSDQNYVISFVVPNQKNLTELAK-------KSGI--DG------EW-DDICN 601

  Fly   583 HETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFALIA 647
            |.....|:|.:..::       |:.:.||....|                        ||..|.:
Zfish   602 HTMMEEEVLKVIKEI-------AVTSKLERFEVP------------------------QKIRLSS 635

  Fly   648 HEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            ..::..||.:....|::|..:...|.|.|||||
Zfish   636 EPWTPETGLVTDAFKLKRKELKNHYMKDIERLY 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	165/677 (24%)
acsl4b	NP_001093209.1	PLN02387	26..668	CDD:215217	177/734 (24%)
acsl4b	NP_001093209.1	LC-FACS_euk	81..668	CDD:213293	165/676 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900