Protein Alignment hll and Slc27a1

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_006509734.1
• Gene: Slc27a1 / 26457
• MGIID: 1347098
• Length: 657
• Species: Mus musculus
• Alignment Length: 568
• Identity: 117/568 - (20%)
• Similarity: 177/568 - (31%)
• Gaps: 184/568 - (32%)

  Fly    37 TIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILA 101
            |||..|:....:..:..|||   ..|....||......|...|   |.:...:|......|.:..
Mouse    88 TIPCIFQAVARRQPERLALV---DASSGICWTFAQLDTYSNAV---ANLFRQLGFAPGDVVAVFL 146

  Fly   102 FNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLAT---------GESSVCVVDDAQQMAKLR 157
            ...||:.....|..:||.|.|.:..:...|.:...|.|         ||.:..|.:.::|:.|
Mouse   147 EGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGK-- 209

  Fly   158 AIKERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLAR-------------- 208
                  ..||......||.....|                 ::|.:.:||.
Mouse   210 ------SLLKFCSGDLGPESILPD-----------------TQLLDPMLAEAPTTPLAQAPGKGM 251

  Fly   209 ESRIRANECAMLIFTSGTVGMPKAVMLSHDN----LVFDTKSAAAHMQDIQVGKESFVSYLPLSH 269
            :.|:      ..|:||||.|:|||.::.|..    ..|...|.:....|:      ....|||.|
Mouse   252 DDRL------FYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADV------LYDCLPLYH 304

  Fly   270 VAAQIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARP 334
            .|..|..|      ..||.:.....|:             |.|...|.::...:...........
Mouse   305 SAGNIMGV------GQCVIYGLTVVLR-------------KKFSASRFWDDCVKYNCTVVQYIGE 350

  Fly   335 YSRLLLAR-ARAAVAEHQTTLMAGKS--PSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAP 396
            ..|.||.: .|.....|:..|..|..  |:|:
Mouse   351 ICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIW--------------------------------- 382

  Fly   397 TSEELKQFFLGLDIALGECYGMSETSGAITLNVDISNLYSAGQACEGVT-------LKIHEP--- 451
              ||..|.| |:. .:||.||.:|.:.:|. |:| ..:.|.|.....:|       :|::|.
Mouse   383 --EEFTQRF-GVP-QIGEFYGATECNCSIA-NMD-GKVGSCGFNSRILTHVYPIRLVKVNEDTME 441

  Fly   452 ---DCNG------QGEILMRGRLV-----------FMGYLGLPDKTEETV------KEDGWLHSG 490
               |..|      .||   .|.||           |.||:. ...|.:.:      |.|....||
Mouse   442 PLRDSEGLCIPCQPGE---PGLLVGQINQQDPLRRFDGYVS-DSATNKKIAHSVFRKGDSAYLSG 502

  Fly   491 DLGYIDPKGNLIISGRLKELIITAG------GENIPPVHIEELIKKEL 532
            |:..:|..|.:....|       :|      |||:....:|.::.:.|
Mouse   503 DVLVMDELGYMYFRDR-------SGDTFRWRGENVSTTEVEAVLSRLL 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	110/543 (20%)
Slc27a1	XP_006509734.1	Adenylate forming domain, Class I superfamily	115..622	CDD:473059	109/538 (20%)