DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and acs-4

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_498568.1	Gene:	acs-4 / 176005	WormBaseID:	WBGene00018152	Length:	731	Species:	Caenorhabditis elegans

Alignment Length:	714	Identity:	179/714 - (25%)
Similarity:	302/714 - (42%)	Gaps:	135/714 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SQTVP-PQTIPEFFKESCEKYSDLPAL-------VWETPGSGNDGWTTLTFGEY--QERVE-QAA 83
            |:|.| ..|:.:.:::..|.|.:.|.|       |.|....|...:.....|||  |...| :..
Worm    86 SETFPGKDTVDKVWRKCVELYDESPCLGTRQLIEVHEDKQPGGRVFEKWHLGEYVWQSYKEVETQ 150

  Fly    84 LMLLSVGV------EERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGES 142
            :..|:.|:      |:...|.|.|....:|........||...:..||.:...:|:.|.:...|:
Worm   151 VARLAAGIKDLAHEEQNPKVVIFAETRADWLITALACFRANVTIVTVYATLGEDAIAHAIGETEA 215

  Fly   143 SVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELK-EELL 206
            :: :|..::.:.|:..:.::.|.||.:|     :.|.||.:.........::| |...|. ..||
Worm   216 TI-LVTSSELLPKIVTLGKKCPTLKTLI-----YFAPVDQKAPAPELAPFRDQ-FKHVLSLSGLL 273

  Fly   207 AR------ESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQVG----KESF 261
            .|      ||....::.|::::||||.|.||.|:|.|.|:|     ||...|...||    .:::
Worm   274 TRNQEQVKESTAVKSDIALIMYTSGTTGQPKGVILLHQNVV-----AALLGQGDGVGIICNADTY 333

  Fly   262 VSYLPLSHVA---AQIFDVFLG--LSHAGCVTFADKDA--LKGTLIKTFRKARPTKMFGVP---- 315
            :.||||:|:.   |::..:..|  :.::..:|..|:.:  .||| .......|||.|..||
Worm   334 IGYLPLAHILELDAELTCLTKGAKVGYSSPLTLHDRASKIQKGT-HGDCHALRPTLMAAVPAIMD 397

  Fly   316 RVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIRE 380
            |:|:.:.|.:.|:....:...:|...|.|:...|              |....:|...|.|.||.
Worm   398 RIFKAVSEEVAASPRFMQELFKLNYERKRSRYLE--------------GYCSPFLDRIVFKKIRR 448

  Fly   381 MIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGEC------YGMSETSGAITLNVDISNLYSAGQ 439
            ::| ...|...:||||.:.|.::|   ::|.:  |      ||::||.||..: .||::| |.|.
Worm   449 LLG-GKLRGVLSGGAPLNAETQRF---MNICM--CCPVVQGYGLTETCGAACV-ADINDL-STGT 505

  Fly   440 A-----CEGVTLK---------IHEPDCNGQGEILMRGRLVFMGYLGLPDKTEE---TVKEDGWL 487
            .     |..:.|:         .::|.   |||||:.|..:..||...|:||.|   |.|...:.
Worm   506 VGPPVRCSDIALREWSEGGYSPFNDPP---QGEILISGENISPGYYKQPEKTAEDFITYKGKVYF 567

  Fly   488 HSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLL 552
            .:||:|.....|:|:|..|.|:|:....||.:....:|..: ...|.|.|:.:.|...:...|.|
Worm   568 ATGDIGQKRDDGSLLIIDRKKDLVKLQHGEYVSLAKVECAL-LNCPIVDNICVYGSGMEDSVVAL 631

  Fly   553 SLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPK 617
            .          :|    .::.:|.:.:.:...|  ||:..:..|.::            |.|..|
Worm   632 V----------VP----NQKHLEKIAEAEGVST--SEMKTMCEDKKV------------IAAYKK 668

  Fly   618 LLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLYK 681
            .||      :.|.|..:|.::......|....::..||.|...||::|..:...|.|.::.|||
Worm   669 QLE------EHAKKSKLSRSEIPAAIHLCPEIWTPDTGLLTEALKLKRKPIQMAYQKTLDDLYK 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	166/671 (25%)
acs-4	NP_498568.1	PLN02387	91..725	CDD:215217	173/706 (25%)
acs-4	NP_498568.1	LC-FACS_euk	137..725	CDD:213293	165/660 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810