DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hll and acs-6

DIOPT Version :9

Sequence 1:	NP_609696.1	Gene:	hll / 34822	FlyBaseID:	FBgn0286723	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	133/598 - (22%)
Similarity:	225/598 - (37%)	Gaps:	152/598 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TIPEFFKESCEKYSDLPALVWETPGSGN-------DGWTTL---TFGEYQERVEQAALMLLSVGV 91
            |:.|...|:|..::           |.|       |..||.   .:.:.:..|...|..|:.:|.
Worm    16 TVHERIFEACRIHA-----------SANKDAVCFIDAETTTKKKLYKDVEPTVNSLATALVKLGF 69

  Fly    92 EERSSVGILAF-NCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAK 155
            :. ..|...|| ||||:..|....::.|..::......:...:........:|: |..|..::|:
Worm    70 KP-GDVASQAFPNCPEFLVAMLAVMKCGGAMSNASAIFTDYELQLQFCDSNTSI-VFTDEDRLAR 132

  Fly   156 LRAIKERLPRLKAVIQLHG-PFEA-FVDHEPGYFSWQKLQEQTFSSELKEELLARESRIRANECA 218
            :|....:.|.::.:|.|.. |... |.::...|....:..:|..:           ..:..:..|
Worm   133 IRRATAKCPGVRKIICLRTFPLRTEFPENVLDYVELTQTPDQPIN-----------VNVSMDSIA 186

  Fly   219 MLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQ-DIQVG----------KESFVSYLPLSHVAA 272
            :|.::|||.|.||...|:|.|:......|.||:: |:...          ||..|..||..|.
Worm   187 LLPYSSGTTGRPKGCQLTHRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVLLLPWYHA-- 249

  Fly   273 QIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSR 337
                  .||:               |:.:|....    |.|:  ||:|....::        .:|
Worm   250 ------YGLN---------------TMFETILLG----MTGI--VFKKFDTIVM--------LNR 279

  Fly   338 LLLARARAAVAEHQTTLMAGKSP--SIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEE 400
            :...:.:.|.......:...|.|  .|:..|.:                  .:|..:.||...::
Worm   280 IKFYKVKLAWLVPPMLIFLAKDPMVPIFNTAPF------------------LKVIMSAGATAGKQ 326

  Fly   401 L-----KQFFLGLDIALGECYGMSETSGAITL-NVDISNLY-SAGQACEGVTLKIHEPD------ 452
            |     |:|   .:..|.:.|||:|.....|: ..:..|.: :.|.......|||.:.:
Worm   327 LCEEVSKRF---PNAWLCQAYGMTEMVQFTTIPRFEDGNCFETVGNLASTYELKILDKEKKEITT 388

  Fly   453 CNGQGEILMRGRLVFMGYLGLPDKTEET--VKEDGWLHSGDLGYIDPKGNLIISGRLKELIITAG 515
            .|..|::..||..|..|||    |.||.  :.:||:|.:||||.||.||.:.::||:||| |...
Worm   389 INTVGQLCFRGPTVMKGYL----KREEADIIDKDGFLLTGDLGSIDDKGRIHVTGRIKEL-IKVN 448

  Fly   516 GENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWL--R 578
            |..:|||.||:::                      ||..|.|..|..|:|.:...|....::  :
Worm   449 GMQVPPVEIEDVL----------------------LLHPKVKDCAVIGVPDEHKGESPKAYIVKK 491

  Fly   579 DLDIHETRLSELL 591
            |..:.|..|:|.:
Worm   492 DHTLTEAELTEFV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	129/573 (23%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	133/598 (22%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	127/566 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930