Protein Alignment hll and Acsl6

DIOPT Version :10

• Sequence 1: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_063124394.1
• Gene: Acsl6 / 117243
• RGDID: 69403
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 708
• Identity: 183/708 - (25%)
• Similarity: 291/708 - (41%)
• Gaps: 141/708 - (19%)

  Fly    36 QTIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLL----SVGVEERSS 96
            :|:.:.|:.......:.|.|.:..|   ...:..|::.|..:|.|.....||    .||.|:  .
  Rat   190 RTMYQVFRRGLSISGNGPCLGFRKP---EQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQ--F 249

  Fly    97 VGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKE 161
            :|:.|.|.|||..||........||..:|.:....::.:::.|.:....:||...:...|....|
  Rat   250 IGVFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSIRYIINTADICTVIVDKPHKAILLLEHVE 314

  Fly   162 R--LPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLARESRI----RANECAML 220
            |  .|.||.|| |..||:..: .|.|    :|......|.:..|:......|:    |.::.:::
  Rat   315 RKETPGLKLVI-LMEPFDDAL-RERG----KKCGVDIKSMQAIEDSGQENHRVPVPPRPDDLSIV 373

  Fly   221 IFTSGTVGMPKAVMLSHDNLVFD-------TKSAAAHMQDIQVGKESFVSYLPLSHVAAQIF--- 275
            .|||||.|.||..||:|.|:|.|       |:......||     :..:|:|||:|:..::.
  Rat   374 CFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQD-----DVLISFLPLAHMFERVIQSQ 433

  Fly   276 ------DV---FLGLS-------------HAGCVTFADKDALKGTLIKTFRKA-RPTKMFGVPRV 317
                  ||   :|.|:             |.|.|.|...|.   .|:....|| |||....|||:
  Rat   434 WAPTCADVHFSYLPLAHMFERMVQSVVYCHGGRVGFFQGDI---RLLSDDMKALRPTIFPVVPRL 495

  Fly   318 FEKLQERLV-AAEAKARPYSRLLLARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIREM 381
            ..::.:::. .|:...:.:  ||...|:...||.::.::  ::.||:....:       ..|:..
  Rat   496 LNRMYDKIFHQADTSLKRW--LLEFAAKRKQAEVRSGII--RNNSIWDELFF-------NKIQAS 549

  Fly   382 IGVDNCRVFFTGGAPTSEELKQFFLGLDIALG----ECYGMSETSGAITLNVD---ISNLYSAGQ 439
            :| .:.|:..||.||.|..:..|   |..|||    |.||.:|.:...|....   .|....|..
  Rat   550 LG-GHVRMIVTGAAPASPTVLGF---LRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPL 610

  Fly   440 ACEGVTLKIHEPDCN-----GQGEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKG 499
            .|..:.| :...:.|     |:|||.::|..||.|||...|:|:|.:..|||||:||:|...|:|
  Rat   611 PCNHIKL-VDAEELNYWTSKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEG 674

  Fly   500 NLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLK----TKCDA 560
            .|.|..|.|.:...|.||.:.|..||.:..:..| |:.:.:.||..|...|.:.:.    ..|.|
  Rat   675 TLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSEP-VAQIYVHGDSLKAFLVGIVVPDPEVMPCWA 738

  Fly   561 -KTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLE--AI 622
             |.||                   |....||                       .|.|.|:  .:
  Rat   739 QKKGI-------------------EGNYQEL-----------------------CKSKELKKAIL 761

  Fly   623 EEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680
            ::.:....:..:.:.::|:...:....|||..|.|.||||.:|..:...:.|.||.||
  Rat   762 DDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELY 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	176/680 (26%)
Acsl6	XP_063124394.1	None